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Time Domain OCT   Spectral Domain OCT
IS/OS
OS/MV
RPE
Spectral Domain OCT   (Enhanced Depth Imaging tech)
RPE Changes in SD-OCT

                  Thickness
   Variation     Contour        Vs. Shadowing artifacts.
                  Irregularities
                  Fragmentation

   Detachment of Bruch’s membrane.

   Abnormal structures anterior or posterior to the RPE.
1. RPE band thickening
   Localized thickening   Occult CNVM
1. RPE band thickening
   Localized thickening   Proliferation at edges of atrophy
2. RPE band thinning
   Localized or diffuse thinning   Atrophy
2. RPE band thinning
   Localized or diffuse thinning   Atrophy
2. RPE band thinning
   Localized or diffuse thinning   Atrophy
3. RPE discontinuity
   RPE tear and retraction   CNVM
3. RPE discontinuity
   Shadowing or masking   Hge, intraretinal deposits,
                           Blood vessels
3. RPE discontinuity
   Shadowing or masking   Hge, intraretinal deposits,
                           Blood vessels
3. RPE discontinuity
   Shadowing or masking   Hge, intraretinal deposits,
                           Blood vessels
3. RPE discontinuity
   Shadowing or masking   Hge, intraretinal deposits,
                           Blood vessels
4. RPE elevation
   Drusen
4. RPE elevation
   Drusen- large or confluent
            “Drusenoid RPE detachment”
4. RPE elevation
   Drusen- large or confluent
            “Drusenoid RPE detachment”
4. RPE elevation
   Drusen   Reticular Drusen or pseudodrusen
             “Subretinal drusenoid deposits”
4. RPE elevation
   Drusen   Reticular Drusen or pseudodrusen
             “Subretinal drusenoid deposits”
4. RPE elevation
   RPE Detachment   • Serous
                     • Fibrovascular

                     • Hgic
4. RPE elevation
   RPE Detachment   Serous
                     •

                     Occult CNVM
4. RPE elevation
   RPE Detachment   Serous
                     •

                     Occult CNVM
4. RPE elevation
   RPE Detachment   •   Serous CSCR
4. RPE elevation
   RPE Detachment   •   Serous CSCR
4. RPE elevation
   RPE Detachment   •   Hgic, Vascular and Fibrovascular
4. RPE elevation
   RPE Detachment   •   Hgic, Vascular and Fibrovascular
4. RPE elevation
   RPE Detachment   •   Hgic, Vascular and Fibrovascular
5. Abnormal deposits
Vitelliform material
                      Best disease
5. Abnormal deposits
Vitelliform material
                      Adult type
5. Abnormal deposits
   Inflammatory deposits   APMPPE
5. Abnormal deposits
   Inflammatory deposits   APMPPE
“It is through living that we discover
ourselves, at the same time as we discover
  the world around us.” ….. Henri Cartier-
                   Bresson

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RPE changes in OCT

Editor's Notes

  1. In AMD patients, Yannuzzy found an incidence of 4% of non-vascularized PED among serous PED(22).