Diuretics

1. Assignment 2
Nick: questions e and f:
Plasma sodium, aldosterone and creatinin will not change
(However, this answer might change)
Sebastiaan: questions g and h

2. What is this person’s creatinin clearance rate?
Urine flow per day * Concentration of creatinine in urine
Concentration of creatinin in plasma
Day 1:
2,44 L/Day * 7 mmol/L
0.102 mmol/L
= 167,45 L/Day
Day 7:
2,40 L/Day * 7 mmol/L
0.099 mmol/L
= 169,7 L/Day

3. Why even calculate creatinin clearance?
• Estimate of GFR
• Thus estimate of Renal function
• However.. using creatinin overestimates GFR
http://www.clinicalculator.com/english/nephrology/cockroft/cca.htm
Correction factors are often used:
This answer would be: 122,73 L/Day

4. Will his CCR change?
Why would it change?
• Decreased blood volume
• Decreased blood flow
• ADH, Ras, Renal artery stenosis
or:
Will his GFR change?
Thiazide?

5. Question h: What is the sodium reabsorption per day,
and how is it influenced by the diuretic?

6. Mechanism:
Inhibits
reabsorption
of NaCl
Promotes
reabsorption
of Ca+