1. Not all genotyping tests predict response or non-response to therapeutics. Refer to respective test package inserts as applicable.
Zanger UM, Klein K, Thomas M, Rieger JK, Tremmel R, Kandel BA, Klein M, Magdy T. Genetics, epigenetics, and regulation of drug-metabolizing cytochrome p450 enzymes. Clin Pharmacol Ther. 2014;95(3):258-61.
Source: P450 Drug Interaction Table. Indiana University School of Medicine. Cited 2014 July. http://medicine.iupui.edu/clinpharm/ddis/clinical-table/
©2014 Luminex Corporation. All rights reserved. The trademarks mentioned herein are the property of Luminex or their respective owners.
Determining CYP450 genotypes can help classify patients into the right metabolizer status.
Poor Metabolizers
In people who process a certain drug more slowly than normal because of a missing enzyme, the
medication can build up in their system. This can increase the likelihood that it will cause side
effects. These people may still be able to benefit from these medications, but at lower dosages.
Normal Metabolizers
People with normal metabolizers are more likely to benefit from treatment and have fewer side
effects.
Intermediate Metabolizers
People with reduced enzyme function in processing drugs may not process some medications as
well as normal metabolizers do. This can increase a risk of side effects and drug interactions.
Ultra-rapid Metabolizers
People in which medications leave the body too quickly, often before they have a chance to work
properly. Physicians may elect to prescribe higher than usual doses of medication(s).
CYP2D6
CYP3A4/A5/A7
Antidepressants:
ELAVIL®
(amitriptyline)
ANAFRANIL®
(clomipramine)
NORPRAMIN®
(desipramine)
CYMBALTA®
(duloxetine)
PROZAC®
(fluoxetine)
TOFRANIL®
(imipramine)
PAXIL®
(paroxetine)
Antipsychotics:
HALDOL®
(haloperidol)
RISPERDAL®
(risperidone)
Beta Blockers:
COREG®
(carvedilol)
TIMOPTIC®
(timolol)
Antihistamines:
CHLOR-TABS®
(chlorpheniramine)
Benzodiazepines:
XANAX®
(alprazolam)
HALCION®
(triazolam)
Calcium Channel Blockers:
NORVASC®
(amlodipine)
CARDIZEM®
(diltiazem)
PLENDIL®
(felodipine)
PROCARDIA®
(nifedipine)
SULAR®
(nisoldipine)
VERELAN®
(verapamil)
HIV Antivirals:
CRIXIVAN®
(indinavir)
NORVIR®
(ritonavir)
FORTOVASE®
(saquinavir)
Macrolide antibiotics:
BIAXIN®
(clarithromycin)
KETEK®
(telithromycin)
PDE-5 Inhibitors:
VIAGRA®
(sildenafil)
LEVITRA®
(vardenafil)
HMG CoA Reductase
Inhibitors:
LIPITOR®
(atorvastatin)
MEVACOR®
(lovastatin)
ZOCOR®
(simvastatin)
Immune Modulators:
RESTASIS®
(cyclosporine)
Other:
VIRAMUNE®
(nevirapine)
CYP1A2
CLOZARIL®
(clozapine)
FLEXERIL®
(cyclobenzaprine)
CYMBALTA®
(duloxetine)
LUVOX®
(fluvoxamine)
HALDOL®
(haloperidol)
TOFRANIL®
(imipramine)
MEXITIL®
(mexiletine)
RELAFEN®
(nabumetone)
ALEVE®
(naproxen)
ZYPREXA®
(olanzapine)
RILUTEK®
(riluzole)
COGNEX®
(tacrine)
THEOLAIR®
(theophylline)
ZANAFLEX®
(tizanidine)
DYRENIUM®
(triamterene)
ZYFLO®
(zileuton)
ZOMIG®
(zolmitriptan)
GLUCOTROL®
(glipizide)
GLYNASE®
(glyburide)
CELEBREX®
(celecoxib)
LESCOL®
(fluvastatin)
DILANTIN®
(phenytoin)
AVANDIA®
(rosiglitazone)
DEMADEX®
(torsemide)
DEPAKENE®
(valproic acid)
COUMADIN®
(warfarin)
ACCOLATE®
(zafirlukast)
Angiotensin Receptor Blockers:
COZAAR®
(losartan)
AVAPRO®
(irbesartan)
NSAIDs:
SOLARAZE®
(diclofenac)
ADVIL®
(ibuprofen)
ALEVE®
(naproxen)
FELDENE®
(piroxicam)
CYP2B6
WELLBUTRIN®
(bupropion)
SUSTIVA®
(efavirenz)
IFEX®
(ifosfamide)
KETALAR®
(ketamine)
DEMEROL®
(meperidine)
METHADOSE®
(methadone)
VIRAMUNE®
(nevirapine)
DIPRIVAN®
(propofol)
ZELAPAR®
(selegiline)
Anti-epileptics:
VALIUM®
(diazepam)
DILANTIN®
(phenytoin)
NEXIUM®
(esomeprazole)
PPIs:
PREVACID®
(lansoprazole)
PRILOSEC®
(esomeprazole)
PROTONIX®
(pantoprazole)
Others:
ELAVIL®
(amitriptyline)
SOMA®
(carisoprodol)
CELEXA®
(citalopram)
ANAFRANIL®
(clomipramine)
PLAVIX®
(clopidogrel)
TOFRANIL®
(imipramine)
TRANDATE®
(labetalol)
PALUDRINE®
(proguanil)
VFEND®
(voriconazole)
CYP2E1
Anesthetics:
ETHRANE®
(enflurane)
FLUOTHANE®
(halothane)
FORANE®
(isoflurane)
PENTHROX®
(methoxyflurane)
ULTANE®
(sevoflurane)
Others:
LORZONE®
(chlorzoxazone)
MICROBAN®
(ethanol)
CYP2C9
CYP2C19 3%
7%
7%
9%
20%
30%
13%
%ofdrugs
metabolized by
CYP450