View our hands-on demonstration of the Doppler Flow Velocity System. In this session we covered: Measurement for Cardiac systolic and diastolic function Serial measurements in response to interventions Severity of transverse aortic constriction (TAC) Coronary flow distribution Hyperemic velocity responses Pulse Wave Velocity from two aortic locations simultaneously The Doppler Flow Velocity System (DFVS) is a non-invasive, real-time pulsed Doppler measurement device for studying cardiovascular function in a variety of small animal models, such as mice and rats. The system is ideally suited to analyze the rapid heart rates found in these species, due to the high frequency and excellent temporal resolution.  The data is acquired using a very small probe, 2-3mm in diameter, allowing for more accurate and reproducible data to be acquired. Holding the probe with a steady hand or mounted in a micromanipulator, researchers can acquire many systolic and diastolic cardiac function parameters, as well as parameters from peripheral vessels such as the carotid, renal, and femoral arteries, plus indices from the coronary vessels

1. Doppler Flow Velocity
System
(DFVS)

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Doppler Flow Velocity System
• Noninvasively evaluate cardiovascular physiology and
function.
• The system consists of four components:
• Pulsed Doppler Transceiver,
• Doppler Signal Digitizer,
• Doppler Workstation,
• and Handheld Probe.
• Surgical warming and real-time integration of ECG signals to
the DFVS software from the Rodent Surgical Monitor+.
• 2mm diameter handheld probe achieves ~15° angles.
Doppler Flow Velocity System 2

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Pulsed Doppler Ultrasound
• Achieving consistency and accuracy with
proper measurement angle…
• V = (c Δf) / (2fo cos θ)
• θ = angle between velocity vector & beam
vector
Doppler Flow Velocity
System
3
Optimal Angle = ~15°

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Using Pulsed Doppler Ultrasound
4
Advantages
 Noninvasive - longitudinal studies
 Short signal acquisition times
 Can be measured at various locations
 Signals from 2 sites can be combined
 Possible to achieve small angles
Know-How
 Knowledge of anatomy
 Shapes and timing of waveforms
Doppler Flow Velocity
System

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Main Applications
 Systolic & Diastolic Function
 Confirmation and Stratification of TAC
 Coronary Flow Reserve
 Aortic/Arterial Stiffness
 Peripheral Flow Perfusion
Doppler Flow Velocity System 5
Mouse Heart Mouse Aorta

6. Globally linking scientists with
precision tools for research
through expertise in science,
engineering and support

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Q & A
info@scintica.com
www.scintica.com
Thank you