Challenging concept in trauma - straight to the heart | Samy Sadek at TBS23
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This document discusses challenging trauma cases and concepts in emergency medical treatment. It presents five case studies involving severe bleeding and considers different emergency interventions like REBOA, thoracotomy, and cardiovascular support techniques. The document emphasizes that trauma treatment is complex and physiology complicated, and stresses the importance of targeted care from the start to support the heart as the pump in cases of hemorrhage.
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There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
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Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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Challenging concept in trauma - straight to the heart | Samy Sadek at TBS23
- 1. Challenging Concepts in Trauma BIG SICK. ZERMATT 2023 Straight to the heart of the matter..
- 2. WHY ME?!..
- 4. A CASE IN POINT..
- 5. A CASE IN POINT..
- 6. A CASE IN POINT..
- 7. A CASE IN POINT.. • What is wrong with him? • What does he need? • How long has he got? • Does he need something ‘extreme’? • What then?..
- 8. A CASE IN POINT.. • What is wrong with him? • What does he need? • How long has he got? • Does he need something’ extreme’? • What now?..
- 9. A CASE IN POINT.. • What is wrong with him? • What does he need? • How long has he got? • Does he need something ‘extreme’ • What now?.. Bleeding Blood and surgery Signs? Obs? Data? REBOA? Thoracotomy? DCS and ITU - organ support
- 10. Over to the experts..
- 11. Back to our questions..
- 12. A CASE IN POINT.. • What is wrong with him? • What does he need? • How long has he got? • Does he need something ‘extreme’? • What then?..
- 13. A CASE IN POINT.. • What is wrong with him? • What does he need? • How long has he got? • Does he need something ‘extreme’ • What now?.. Cardiac failure? Perfuse coronaries? Support pump? Signs? Obs? Data? Aortic occlusion: why? how? ECMO?.. EPR??..
- 14. A CASE IN POINT.. • What is wrong with him? • What does he need? • How long has he got? • Does he need something’ extreme’? • What now?..
- 15. 5 Cases in point!..
- 16. Case 1 • Z3 REBOA
- 17. Case 2 • Z1 REBOA • (plus CPR)
- 18. Case 3 • Thoracotomy • (left lateral)
- 19. Case 4 • Thoracotomy • (clamshell)
- 20. Case 5 • Blood and run!..
- 21. Tackling the ‘real’ problem
- 22. PHYSIOLOGY OF HAEMORRHAGE ▪ Sadly, way more complicated!
- 24. THE PUMP ▪ Needs targeted care from the very outset
- 26. TAKE HOMES?
- 28. Thank you The London HEMS Team