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3D Printing of Various Pharmaceutical Dosage Forms
1. MIT-WPU | School of Pharmacy
WORLD’S FIRST UNIVERSITY
FOR LIFE TRANSFORMATION
3D Printing of Various Dosage Forms
Name: Ms. Rutuja Sanjay Desai
Guide: Dr. Ashwin B. Kuchekar
12/20/2023 1
2023-2024
Presentation on
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INTRODUCTION
• 3D printing is one of the most revolutionary & powerful tool serving
as technology of precise manufacturing of individually developed
dosage form.
• 3D printing can play a significant role in multiple active ingredient
dosage forms, where the formulation can be as a single blend or
multi layer printed tablets with sustained release properties.
• It allows the rapid conversion of information from digital 3D mode
into a physical object.
• It is a process of creating an object using a machine that puts down
the material layer by layer in three dimensions until the desired
object is formed.
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INTRODUCTION
• The term three dimensional printing was defined by ISO(international
standard organization) as " fabrication of object through the deposition
of a material using a print head, nozzle or another printer technology.
• 3D printing technology has high potential in individualized dosage
form concept called the polypill concept.
• Three dimensional printing technology is a novel rapid prototyping
technique in which solid objects are constructed by depositing several
layers in sequence.
• It is also called as additive manufacturing.
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3D printing drug is to design and develop medicine that are suited to
an individual's need.
In this we can easily adjust size, shape, appearance and rate of
delivery of a wide range of medicine.
3D printing methods gain an importance in the field of
pharmaceutical sciences because of the possibility of rapid preparation
of tailor-made object which can be personalized therapy.
Its aims is to development of patient centered dosage form based on
structure design.
OBJECTIVE
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STEPS INVOLVED IN A 3D PRINTED DOSAGE FORM
• Pharmaceutical product is designed in
three dimension with computer aided
design.
• Design is converted to a machine
readable format which describes the
external surface of the 3D dosage form.
• The computer program then slices this
surface into several distinct printable
layers and transfers that layer by-layer to
the machine.
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It is similar to desktop inkjet printer.
It is also called as powder bed jetting.
Droplet of solution containing drug sprayed from print head bind the layer of free
powder bed
While unbound powder particles act as support material
Which prevent collapsing of porous structure
Formed object is lowered and a layer of free powder is applied by roller or powder
jetting system
Drop on solid deposition
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Selective Laser Melting
• It is similar to drop on solid method.
• Here the powder can be solidified by applying the beam of high energy.
Powder bed is transformed from one compartment to another
Leveling and layering are formed by sintering or melting the polymeric
powder bed by laser beam
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• Also called as polyjet technology
Droplet of solution containing drug sprayed from the nozzle
Deposit on thin layer
Cured by cooling air or in presence of high energy
Print head moves along X&Y axes during printing
Print platform bed is lowered along 2 axis by the height of the layer after the
deposition of each layer of the material
Drop on Drop
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Photosensitive liquid polymer are used.
The object is built by solidification of subsequent layers of resin in the
presence of high energy light.
Laser beam guided by scanner mirrors precisely draws layers of the
object on build platform by cross linking of the photopolymer.
Source of light is situated under transparent bottom of a resin tank
which is coated with a non-sticking material.
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Two models of printing method
Extrusion of semisolid Extrusion of thermoplastic
rod-shaped material
In both modes material is extruded from the nozzle and spread in
subsequent layers on the surface of build platform.
Defined dimension of printed path is created by the distance of print
head to the build plate and influenced the nozzle orifice diameter.
Extrusion Based Method
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Stages of preparation of 3D-printed object.
Design 3D object with CAD software &optimize the geometry
Export of 3D model to a printer recognizable file format Ex-STL
Import of the file to the software and generation of layer which will be printed
Fabrication of the object by subsequent application of material layer
3D PRINTED OBJECT
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• Polypill refers to a single tablet that includes the combination of several drugs.
• This concept is highly beneficial for geriatric population, as patients of this age
category are prone to multiple disorders and hence multiple therapy.
• The drugs were physically separated by
a permeable membrane.
• Three-dimensional (3D) extrusion-based
printing was used to manufacture the
'polypill' to demonstrate that complex
medication regimes can be combined
in a single tablet .
Polypill Concept
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High drug loading ability when compared to conventional dosage
forms.
Accurate and precise dosing of potent drugs which are administered at
small doses.
In case of multi drug therapy with multiple dosing regimen, treatment
can be customized to improve patient adherence.
An immediate and controlled release layers can be incorporated due to
the flexible design and manufacture of this dosage form, it helps in
choosing the best therapeutic regime for an individual.
3D printers occupy minimal space and are affordable.
Reduces cost of production due to lesser material wastage.
Advantages of A 3D Printed Drug Delivery
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• Manufacturing of drug delivery system with sophisticated structure.
• Personalized medicine can be made.
• Available in different shapes.
• Multifunctional drug delivery system with accelerated release
characteristics
APPLICATIONS
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First 3D printed drug.
It treats epilepsy.
In 2015, Aprecia Pharmaceutical developed ZipDose patented
technology for 3D -printing drugs.
Oral Suspension Tablet.
It enable to make high dose medication
in a rapid disintegration form.
SPRITAM
24. • Pravin S., Sudhir A., Integration of 3D printing with dosage forms: A
new perspective for modern healthcare, Biomedicine &
Pharmacotherapy 107 (2018) 146–154.
• Okafor-Muo OL, Hassanin H, Kayyali R, ElShaer A, 3D printing of solid
oral dosage forms: numerous challenges with unique opportunities,
Journal of Pharmaceutical Sciences (2020).
• Rofiqul I., Pinkan S., An Insight Of 3d Printing Technology In
Pharmaceutical Development And Application : An Updated Review,
Current Trends in Pharmaceutical Research 2020, 2582-4783.
• Spritam.com
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Reference