New methods of preparation of homoeopathic mother tincture.

1. METHOD OF
PREPARATION OF
HOMOEOPATHIC DRUGS
(NEW METHOD)
- DR. RADHIKA KHANDELWAL

2. PROCESS OF PREPARATION
OF MOTHER TINCTURE
MACERATION
PERCOLATION

3. TERMINOLOGIES
MENSTRUM
Liquid capable of
penetrating the tissues of
plant or animal substances
and capable to dissolve
the active principles
MAGMA
Thick residue of the
soft doughy mass
resulting from
expression of the fluid
part of certain
substances (pounded
fresh plant)
MERC Inert, fibrous and insoluble
material remaining after
expression of juice from
drug material or after
maceration and
percolation.

4. MACERATION
According to A Textbook of Homoeopathic
Pharmacy – Mandal and Mandal
It is a long process of preparation of mother
tincture from vegetable and animal substances
under normal temperature and pressure according
to new method.

5. MACERATION
Substances taken for maceration
•Hard, gummy, mucilaginous drug substance which do
not allow the menstrum to penetrate rapidly due to
small intermolecular spaces.
•Cutting and pounding of the drug substance is done
so as to increase the surface for penetration of
alcohol

6. MACERATION
PROCEDURE -
Pre process -
Moisture content of the drug is to be
calculated with the help of water bath.
MM.DD.20XX

7. MACERATION
Drug substance are
made into pulp(magma)
and is placed in
macerating jar and
prescibed quantity of
alcohol(menstrum) is
added to cover the pulp,
and jar is sealed tightly.
Jar is kept in cool dark
place, free from dust,
odor, heat, direct
sunlight, between 15℃ to
20℃ for 2-4 weeks.
The jar is powerfully
shaken once daily.
After the lapse time,
supernatant fluid is
decanted off and the
residue is pressed out and
added to former tincture.
The total juice obtained is
the mother tincture of the
drug substance.
PROCESS PROPER -

8. MACERATING
JAR

9. MACERATING
JAR

10. MACERATION - PROCEDURE
In case of more viscid and mucilaginous substances where alcohol does not act
fully on sunstance, the process is modified as –
• The drug-substance is made in pulp and placed in macerating jar with half
quantity of pre-calculated menstrum(alcohol) is added and the jar is sealed tightly.
• The jar is kept in a cool dark place for 2-4 weeks and the jar is powerfully shaken
once daily.
• The supernatant fluid is decanted off, residue is pressed out.
• The residual mass which remains behind is taken in a clean porcelain mortar or
pestle and double quantity of green glass powder is added to it and pulverised
and the pulp is placed on the filter bed of percolator with the quantity of
remaining menstrum.
• The resulting tincture is mixed with previously prepared tincture.

11. NOTE -
If the obtained volume of the mother tincture is LESS than the
formula prescribed in pharmacopoeia which is due to –
• Evaporation of alcohol
• Contraction due to mixture of alcohol and water
In such cases required quantity of menstrum(alcohol) is added
for standardization.
If the obtained volume of the mother tincture is MORE than the
formula prescribed in pharmacopoeia, then the volume is
reduced by –
• Gentle heat
• Deducting the portion of water with the addition of calculated

12. PERCOLATION
According to A Textbook of Homoeopathic Pharmacy –
Mandal and Mandal
It is a short process of preparation of mother tincture in
new method, where the vehicle is passed through the
soft, non-gummy and non-mucilaginous drug substance
of vegetable and plant kingdom by an apparatus,
percolator for a definite period of time as per the nature
of the drug-substances according to pharmacopoeia.

13. PERCOLATION
Principle
When the liquid capable of dissolving only a portion
of powdered material is spread on porous material,
and it passes through succeeding layers of powder, it
gets saturated.

14. PERCOLATION
Forces acting in process of percolation
- Gravitation - Osmosis
- Viscosity - Capillary attraction
- Adhesion - Surface tension
- Friction

15. PERCOLATOR
Definition
It is an apparatus, used for percolation, during the
preparation of mother tincture in new method.
There are different types of percolators like copper,
stainless steel, alloy, porcelain or glass.

16. PERCOLATOR
Parts of percolator
•Percolator proper
•Receiver
These two parts are connected with rubber tubing and
glass road.

17. PERCOLATOR
Parts of percolator proper
•Head
•Neck

18. PERCOLATOR
Preparation of percolator
A piece of well-washed muslin is tied to neck of the
percolator.
A tow is placed on the muslin

19. PREPARATION OF
PERCOLATOR - TOWA layer of
maximum coarse
sand
A layer of ½” thick
medium coarse sand
A layer of about ¼”
thick minimum
coarse sand
Plug of an
absorbent cotton
inserted in neck
It is an obstruction
made up of porous
material, placed in or
above the neck and
below the powdered
drug substance.

20. PERCOLATOR

21. PERCOLATOR

22. PERCOLATOR
Preparation of drug substance for percolation
• If dry and hard – finely powdered to give uniform
consistency.
•If fresh – reduced to fine and uniform pulp.
• drug-substance is moistened by mixing sufficient
menstrum.

23. PROCESS OF PERCOLATION
• Desired quantity of drug-substance us moistened
sufficiently by small portion of menstrum and is uniformly
spread over the layers of sand.
•The upper surface of the mass is covered with filter
paper/finely powdered glass.
•Enough quantity of menstrum is taken just to cover the
mass and the lid of the percolator is closed t prevent
from contamination and allowed to s

24. PROCESS OF PERCOLATION
• Then by opening the valve and regulating the stop-
cork, the liquid is allowed to percolate drop by drop, not
exceeding 10-30 drops per minute.
•The menstrum should always be above the level of mass
and fresh quantity of menstrum is to be added from time
to time.
•It is continued till the requisite amount of menstrum is
passed of the percolator.

25. PROCESS OF PERCOLATION
• Once the last drop is received, sufficient quantity of
menstrum is added to cover the mass and the percolator
is sealed tightly and is allowed to stand for 6 hours.
•Then the cork is opened to allow the whole fluid to
collect drop by drop.
•The tincture obtained is to be filtered with white filter
paper.

26. POTENSTISATION
According to New method, the drug power is 1/10,
therefore it is equal to 1X in decimal scale.
The 2X is prepared by = 1 part 1X potency + 9 parts
of vehicle + 10 downward strokes.

27. THANK YOU!