Plant cell technology is an important strategy for the production of plant-based drugs. It has several advantages such as high accuracy, repeatability, and productivity; this technology can be used instead of whole herbs. Learn More : https://pubrica.com/services/research-services/systematic-review/ Reference: https://bit.ly/3OgWtup Why Pubrica: When you order our services, we promise you the following – Plagiarism free | always on Time | 24*7 customer support | Written to international Standard | Unlimited Revisions support | Medical writing Expert | Publication Support | Bio statistical experts | High-quality Subject Matter Experts.   Contact us:      Web: https://pubrica.com/  Blog: https://pubrica.com/academy/  Email: sales@pubrica.com  WhatsApp : +91 9884350006  United Kingdom: +44-1618186353

1. A SYSTEMATIC REVIEW AND
META-ANALYSIS OF PLANT CELL
TECHNOLOGY FOR PRODUCTION
OF NATURAL-BASED DRUGS–
PROTOCOL AND BRIEF OUTCOME
–PAPER COMMENTARY.
An Academic presentation by
Dr. Nancy Agnes, Head, Technical Operations, Pubrica
Group: www.pubrica.com
Email: sales@pubrica.com

2. TODAY'S DISCUSSION
In brief
Introduction
Inclusion criteria
Meta-analysis
Results
Discussion
Conclusion
About Pubrica

3. IN BRIEF
Natural-based drugs are important bioactive
substances that have been used for the prevention
and treatment of diseases.
Natural products are prepared on a commercial scale
from relevant medicinal plants. Hence, large plants
are needed to extract and isolate naturally occurring
compounds.
Plant cell technology is the best strategy for plant-
derived drugs, which have difficulty processing
large-scale production.

4. The purpose of this blog was to critically review the
systematic review and meta-analysis published in
the Journal
Research
Azadbakht (2019) from the Department
of Pharmaceutical and Biomedical
by Davoodi, Khoshvishkaie and
of
Pharmacognosy Faculty of Pharmacy, Mazandaran
University of Medical Sciences, Sari, Iran.
The paper attempted to determine the kinds,
frequencies, and
technology-based
efficacies of plant cell
manufacturing techniques for
natural-based pharmaceuticals as an alternative to
whole-herb preparation.

6. This Systematic Review and Meta-analysis found
that all production techniques had high efficacies
and large-scale production percentages ranging
from 90 to 100%, equivalent to traditional direct
extractions.

7. INTRODUCTION
Natural-based drugs are important bioactive
substances that have been used for the prevention
and treatment of diseases.
Moreover, several conditions are needed to develop
novel drugs with higher efficacies and common side
effects. Natural sources play important roles in the
production of drugs.
Surprisingly, some natural-based drugs are the only
choices for preventing and treating relevant
diseases.

8. In addition, natural-based compounds especially plant isolated substances, are the
main important patterns for effective drug design in drug discovery studies.
Several phytochemical compounds, especially alkaloids, saponins, terpenoids and
flavonoids, have been used for medicinal purposes.
These compounds have been isolated from the important plant families. For
instance, Atropa, Scopolia, Duboisia, Datura, Hyoscyamus and Mandragora plants
from Solanaceae family have anticholinergic alkaloids, Catharanthus plant from
Apocynaceae family and Taxus plant from Taxaceae family have the anticancer
alkaloids, Artemisia plant from Asteraceae family contains antimalarial
sesuiterpene lactones, and Papaver plants from Papaveraceae family contains
antinociceptive and antitussive alkaloids.

9. Moreover, fungi and marine sources contain some similar compounds. The
important plant-based drugs, occurring plants, structural formula, medicinal uses
and mechanisms of action.
These natural-based drugs should be produced commercially using relevant
medicinal plants cultivated or in nature. Hence, large amounts of the plants are
needed to extract and isolate the mentioned compounds that threaten the
environment and living organisms in most cases.
Extraction of paclitaxel from the bark of Taxus brevifolia is one of the examples
which is damage to the plant. Then, alternative methods should produce natural-
based drugs, especially plant-derived compounds.

10. The Cochrane Library, MEDLINE/PubMED, Scopus
and Embase were searched. The risk of bias was
assessed using Cochrane tool. All of the themes
stated below were reviewed in the selected
publications from the above-mentioned databases:
Secondary metabolite production with at least two-
fold higher than primary conditions
Secondary metabolite production with optimised
conditions
The collection of the best plant species for the
production of pharmaceutical, natural compounds
The selection of the best plant cell lines
INCLUSION CRITERIA

11. All data for high scale Meta-analysis Expert’s production of
secondary metabolites and five selected drugs were extracted and
collected from peer-reviewed original articles that have been
obtained from scientific journals.
Moreover, data have been filtered and removed the duplicate
cases and arranged using RevMan® software. The final data
Writing A Meta-analysis were coded, including the percentages of
methods and effective methods. In addition to a number of cases,
all methods and outcomes have been calculated based on the
obtained data, and all patients have been analysed.
META-ANALYSIS

12. In the study, four main methods for producing five
high important plant-based drugs, including
atropine, paclitaxel, vincristine, camptothecin and
colchicine, have been selected and evaluated.
The main techniques and plant sources for the
production of mentioned drugs. According to the
results, the frequency of cell suspension, callus,
hairy root and immobilised plant cell methods for
producing the drugs was 30.79%, respectively.
METHODS FOR PRODUCTION

13. Based on the Clinical Meta-Analysis Experts
results, the efficacy values of more important
methods for producing the plant-based drugs
were approximately 90% to 100%.
Many challenges have been made to optimise
the production of plant-based drugs by
alternative practices, but no extensive studies
have been done to control the efficacy of
these methods.
DISCUSSION

14. Plant cell technology is an important strategy
for the production of plant-based drugs.
It has several advantages such as high
accuracy, repeatability, and productivity; this
technology can be used instead of whole
herbs.
These methods should be optimised and
commercialised for each natural compound
CONCLUSION

15. Pubrica's team of researchers and authors develop Scientific and medical
research papers that can be indispensable tools to the practitioner/authors.
Pubrica medical writers help you write and edit the introduction by
introducing the reader to the shortcomings or empty spaces in the identified
research field.
Our experts know the structure that follows the broad topic, the problem,
and background and advance to a narrow topic to state the hypothesis.
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