Sickle cell disease is a blood disorder that affects red blood cells. The red blood cells take on a rigid sickle shape, losing flexibility and ability to flow through blood vessels, preventing oxygen from reaching tissues. It is caused by a mutation in the hemoglobin molecule called hemoglobin S. Common symptoms are repeated infections and episodes of pain. The disease is most prevalent among those living in sub-Saharan Africa. While there is no cure currently, managing pain and receiving blood transfusions can help treat the disease.