This document summarizes a presentation on the impacts of sludge stabilization processes and sludge origin on the mobility of pharmaceuticals following sludge land-spreading. It was presented by Magali Casellas and Marilyne Soubrand from Limoges University in France. The presentation discussed key results from previous studies showing that the desorption ability and availability of pharmaceuticals is highly dependent on the sludge origin, stabilization process, and properties of the pharmaceutical compound. Laboratory experiments simulating sludge land-spreading found very low concentrations of pharmaceuticals in leachates and no ecotoxicity, with most compounds not detected. The presentation calls for further work to link pharmaceutical availability to sludge characteristics and properties to develop a predictive
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Impacts of Sludge Stabilization on Pharmaceutical Mobility
1. ESPP workshop on organic contaminants in sewage bioSolids Malmö 27/10/16
Impacts of sludge stabilization
processes and sludge origin on the
mobility of pharmaceuticals
following sludge land-spreading
Magali Casellas & Marilyne Soubrand,
Limoges University France
1
2. 2
Topics :
PROCESS ENGINEERING : Wastewater and
waste biological treatment.
MICROPOLLUTANTS : Fate during biological
processes implementation and impact on
process design.
Who are we ????
Magali CASELLAS-Français
Associate Professor
Maryline SOUBRAND
Associate Professor
Topics :
SOIL GEOCHEMISTRY : fate of
pharmaceutical compounds in soils
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
3. 3
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
Influent
Effluent
Sludge
treatment line
Thickening Stabilization Déshydratation
Landspreading
(75% of
stabilized
sludge in
France)
Chemical Biological
- Liming
- Digestion
- Composting
Soils
?
FEW RESULTS DEPENDING BOTH ON
MOLECULES, SLUDGE AND
STABILISATION TREATMENT
60%
3
20%
20%
PHARMACEUTICAL COMPOUNDS : AN IMPORTANT ISSUE FOR SLUDGE LANDSPREADING
4. Impacts of sludge stabilization processes and sludge origin on
the mobility of pharmaceuticals following sludge land-
spreading
SOME KEY RESULTS FROM PREVIOUS STUDIES
4
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
5. Influent
Effluent
Sludge
treatment line
Thickening Stabilization Déshydratation
Landspreading
(75% of
stabilized
sludge in
France)
Chemical Biological
Liming Anaerobic Digestion
5
SoilsSIPIBEL PROGRAM (Pilot Site of
Bellecombe, Haute-Savoie,
France, near boarder with
Switzerland)
5
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
TWO SLUDGE ORIGIN : WWTP with 2
separate lines of treatment (urban effluent
and hospital effluent)
urban effluent
hospital effluent
TWO STABILIZATION PROCESSES
7. a (Limed sludge) B (Digested sludge)
The antibiotic ciprofloxacin exhibited the highest concentration in sludge, whatever
the treatment and origin of the sludge.
Lachassagne et al., 2015, DOI 10.1007/s11356-015-4918-4, ESPR
Total concentration (µg/gTS) Total concentration (µg/gTS)
7
Impact of sludge stabilization process on the concentration of 11 pharmaceutical compounds in urban and
hospital sludge
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
8. a (Limed sludge) B (Digested sludge)
Some discrepancies in the concentration values of micropollutants with
respect to the stabilization process used (ie Salicylic acid, SMX)
Lachassagne et al., 2015, DOI 10.1007/s11356-015-4918-4, ESPR
Total concentration (µg/gTS) Total concentration (µg/gTS)
8
Impact of sludge stabilization process on the concentration of pharmaceutical compounds in urban and
hospital sludge
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
9. Some compounds : no or only slight
effect of sludge treatment
(carbamazepine, paracetamol,
ketoprofene, econazole)
Other compounds : noticeable effect of sludge treatment
Biodegradation : Sulfamethoxazole is the only MP completely
removed during anaerobic digestion (Carballa et al., 2007 ; Narumiya et al., 2013)
Concentrated in particulate fraction of digested sludge
Lachassagne et al., 2014. World Water Congress
& Exhibition 2014, Lisbon Lisbon 21 – 26 September 2014
9
Impact of sludge stabilization steps on the phase distribution of pharmaceutical compounds
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
Case of
urban sludge
10. Micropollutant
desorption ability
Batch TestsSludge Landspreading :
Laboratory soil columns
Centrifugation
Filtration
0.45µm
Agitation
(24h h)
Resuspension (NaCl 0,02M : Pan
et al., 2012)
Limed
sludge
LS
Digested
sludge
DS
T0 T24H
Batch Tests
Availability of micropollutants in sludge before landspreading
10
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
𝐾𝐾𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑 𝑑𝑑 =
[𝑀𝑀𝑀𝑀 𝑠𝑠𝑠𝑠𝑠𝑠 𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠 𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛 𝑡𝑡𝑡𝑡𝑡]
[𝑀𝑀𝑀𝑀 𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝 𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶 𝑡𝑡𝑡]
11. Micropollutant
desorption ability
Batch Tests
Availability of micropollutants in sludge before landspreading
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
𝐾𝐾𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑 𝑑𝑑 =
[𝑀𝑀𝑀𝑀 𝑠𝑠𝑠𝑠𝑠𝑠 𝑠𝑠 𝑠𝑠𝑠𝑠𝑠𝑠 𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛 𝑡𝑡𝑡𝑡𝑡]
[𝑀𝑀𝑀𝑀 𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝 𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶 𝑡𝑡𝑡]
Lachassagne et al. 2015 Environmental Science and Pollution Research
22 (21), pp. 17135-17150
Results highly dependent upon sludge origin,
stabilization process, kind of molecule…..
12. Micropollutant
desorption ability
Batch Tests
Availability of micropollutants in sludge before landspreading
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
𝐾𝐾𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑𝑑 𝑑𝑑 =
[𝑀𝑀𝑀𝑀 𝑠𝑠𝑠𝑠𝑠𝑠 𝑠𝑠 𝑠𝑠𝑠𝑠𝑠𝑠 𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛𝑛 𝑡𝑡𝑡𝑡𝑡]
[𝑀𝑀𝑀𝑀 𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝𝑝 𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶𝐶 𝑡𝑡𝑡]
Lachassagne et al. 2015 Environmental Science and Pollution Research
22 (21), pp. 17135-17150
No direct link
Difficult to establish simple prediction of
desorption ability
𝑲𝑲𝒅𝒅𝒅𝒅𝒅𝒅𝒅𝒅𝒅𝒅𝒅𝒅𝒅𝒅𝒅𝒅𝒅 𝒅𝒅 = 𝐟𝐟 𝑴𝑴𝑴𝑴 𝒔𝒔𝒔𝒔𝒔𝒔 𝒔𝒔 𝒔𝒔𝒔𝒔𝒔𝒔 𝒄𝒄𝒄𝒄𝒄𝒄𝒄𝒄𝒄𝒄𝒏𝒏𝒏𝒏𝒏𝒏𝒏𝒏𝒏𝒏𝒏𝒏𝒏𝒏𝒏𝒏 𝒕𝒕𝒕𝒕𝒕𝒕𝒕𝒕 ? ? ? ? ? ? ? ?
Results highly dependent upon sludge origin,
stabilization process, kind of molecule…..
13. Pharmaceutical concentration
Toxicity :Tests microtox and Daphnies
Leachate
The topsoil sample of grassland (A
horizon 0–10 cm, Cambisol,
pH=5,6, clay 24%, OM 6%)
Micropollutant
desorption ability
Sludge Landspreading :
Laboratory soil columns
Leaching tests
(Lachassagne et al. 2015)
Limed
sludge
Digested
sludgeControl
Direct sludge landspreading
Control = (soil alone)
Simulation of a one year
precipitation in Limousin (France),
Artificial rain CaCl2 0,01M
Soil
?
13
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
Availability of micropollutants in soil during landspreading
14. 14
Leachate
concentration ?
Micropollutant
desorption ability
Sludge Landspreading :
Laboratory soil columns
Leaching tests
(Lachassagne et al. 2015)
Limed
sludge
Digested
sludgeControl
Very low
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
Availability of micropollutants in soil during landspreading
Leachate toxicity?
x
15. Impacts of sludge stabilization processes and sludge origin on the
mobility of pharmaceuticals following sludge land-spreading
15
• SOME KEY RESULTS FROM PREVIOUS STUDIES
Difficult to establish simple prediction of
desorption ability
Results highly dependent upon sludge origin,
stabilization process, kind of molecule…..
Availability of micropollutants in sludge before landspreading ?
Availability of micropollutants in soil during landspreading ?
NO ECOTOXICITY OF THE LEACHATEMost of the pharmaceuticals :
not detected in leachate
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
16. Impacts of sludge stabilization processes and sludge origin on the
mobility of pharmaceuticals following sludge land-spreading
16
• TOWARDS A METHODOLOGY
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
Sludge
Characterization
Functional groups,
biochemical
composition
Desorption
Necessity to link micropollutants
availability with sludge
characteristics (origin, process,…)
and pharmaceutical
characteristics
Pharmaceutical
compounds
17. 17
Ex : urban sludge
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
SLUDGE : SOLUBLE AND PARTICULATE CHEMICAL FUNCTIONAL GROUPS
PHARMACEUTICAL COMPOUND : CHARGE= f(pH)
18. Impacts of sludge stabilization processes and sludge origin on the
mobility of pharmaceuticals following sludge land-spreading
18
• TOWARDS A METHODOLOGY
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
Sludge
Characterization
Functional groups,
biochemical composition
Sorption
+
Desorption
Fate and behaviour of
micropollutants in regard to
sludge characteristics
Necessity to link desorption parameter with sludge
characteristics during treatment
Statistical analysis to rely all the parameters
(sludge, MP, Kd) : predictive aim (e.g.:
influence of a parameter to another on
desorption)
Pharmaceutical
compounds
Log Kdésorption = cste – 0,0042 × (molecular weight)micropol. – 0,11 ×
log(solubility)micropol. + 0,12 × pHboue – 0,013 × (% carboxylic groups in particulate
phase)sludge
Example of PLS regression :
19. Impacts of sludge stabilization processes and sludge origin on the
mobility of pharmaceuticals following sludge land-spreading
19
• TO GO ON
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16
Influence of soil characteristics ? Other organic micropollutants? Other
stabilization processes ? Other fertilizing matter?
ESCO MAFOR
(France,
2014)
IMOPOLDYN
PROJECT (2015-
2018
Interactions micropollutants / organic matrices in the
fertilizer materials of waste origin: influence on the
dynamics of micropollutants during landspreading.
20. THANKS FOR YOUR ATTENTION
20
ESPP workshop on organic contaminants in sewage biosolids Malmö 27/10/16