Reviewing literature and available resources for adding on longevity to life.

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Living Beyond 100 Years
Myth or Truth?
Dr. Parthiv MEHTA
Ahmedabad

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Living Beyond 100 Years
Myth or Truth?
S C I E N C E
Or
C U L T U R E ?

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Tiwari S C, Pandey NM. The Indian concepts of lifestyle and mental health in old age. Indian J Psychiatry 2013;55:288-92

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Yajurveda….

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Indian Culture…

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Life Expectancy
Controversies on Aging, Why do our bodies grow old? by O. Wendell

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Life Expectancy…Then and Now

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Restricted Age… THE REASON
• Dr Tom William of Queen Mary, University of
London describes the role of protective caps
at the end of chromosomes called
“Telomeres” in the aging process.
• When/if “Telomerase” enzyme replace
Telomere Nucleotides, it prevents telomere
shortening during DNA replication.
• It is this enzyme that is responsible for the
extraordinary resistance to aging in naked
mole rats.

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Okinava, Japan

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New England Centenarian Study

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New England Centenarian Study
• Boston University Gerontologist Thomas Perls.
“If we start looking at these genes and what
they do, we better understand the biology of
extreme longevity.”
• Published July 2, 2010 in Science, the findings
come from gene tests of 801 people enrolled
in the Perls-founded New England
Centenarian Study, the largest study in the
world of people who’ve lived past 100.

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New England Centenarian Study
• One of the study’s most intriguing results is
that roughly 15 percent of the general
population has some of the longevity-
associated genes.
• Yet only one in 6,000 people currently live to
be centenarians — many fewer people than
seems to be suggested by the genetics.
What is Statistics for India?

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• The biological aging process is not the result
of a rigid genetic program; it is the complex
and indirect result of multiple traits in the
organism tied to normal development.
• The body may not be preprogrammed to
acquire gray hair, wrinkles, or diminished
metabolic functions.
• These supposed signs of aging may simply be
telltale side effects of activities of the
organism.
Process of Aging

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• Human Body can be an analogy to
“CAR BURNING OXYGEN AS FUEL”
Process of Aging

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Theories of Aging
• “Wear and Tear” Theory
• “Auto-immune” Theory
• “Aging Clock” Theory
• “Cross Linkage” Theory
• “Free Radical” Theory
• “Cellular” Theory

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Is Aging Inevitable?
• The “Human Car”:
– Unlike a manufactured object, has a capacity for
repair and self-regeneration, at least up to a
certain point.
– Capacity for self-repair seems unable to keep up
with the damage rate…
Aging (and Death @ 80) appear to be
INEVITABLE

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REPAIRS : Stem Cells
When fast-aging elderly mice with a usual lifespan of 21 days
were injected with stem cells from younger mice at the Institute
for Regenerative Medicine in Pittsburgh, the results were
staggering.
Given the injection approximately
4 days before they were expected
to die, not only did the elderly mice
live — they lived 3 fold their normal
lifespan, sticking around for 71 days.
In human terms, that would be the equivalent of
an 80-year-old living to be 200.
21
71
Stem Cells Could Extend
Human Life by Over 100 Years

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Is there any Anti Aging Medicine?
• Interventions against stress:
– Reduce Oxidative Stress
– Increase Resistance to Stress
• Hormone Therapy
• Cell Replacement Therapy
• Immune enhancement Therapy SLOW PROGRESS

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Ways to Prolong LifeWays to Prolong HEALTHY Life

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1. Keep Organs Healthy
2. Keep Mind Healthy
3. Keep Bones and Joints Healthy
4. Maintain Healthy Asthetics
5. Maintain Immune function
Ways to Prolong HEALTHY Life

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Ways to Prolong HEALTHY Life
1. Keep Organs Healthy
– Heart, Lung, Liver, Kidney
• Early Detection and management of diseases
• Regular medication
• Preventive Check up
• Preventive Maintenance

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Ways to Prolong HEALTHY Life
1. Keep Organs Healthy
– Heart, Lung, Liver, Kidney
• Early Detection and management of diseases
• Regular medication
• Preventive Check up
• Preventive Maintenance – METABOLIC CONTROL

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Ways to Prolong HEALTHY Life
1. Keep Organs Healthy
– Heart, Lung, Liver, Kidney
• e.g.: Metabolic Control - FAT Metabolism –
Effectively inhibit fat accumulation (Adipogenesis)
and Enhance fat burning (Lipolysis)

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Ways to Prolong HEALTHY Life
1. Keep Organs Healthy
– Heart, Lung, Liver, Kidney
Stern JS et al. J Med Food. 2013 Jun;16(6):529-37
Metabolic Control

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Ways to Prolong HEALTHY Life
2. Keep Mind Healthy
– Stress free life
• Life style modification
• Medication
e.g. Lactium – decapeptide with relaxing properties
• Activates GABA-A receptors by selectively binding
to omega-2 (ω2) subunit (that modulates stress and
anxiety); and offers relaxation without producing
sedation
• Significantly reduces level of plasma cortisol -a
marker of stress
Eur J Nutr. Mar; 44(2):128-32. Epub 2004 Nov2.

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Ways to Prolong HEALTHY Life
3. Keep Bones and Joints Healthy
– Prevention of Osteo-Arhthritis
e.g: 5-LOX (5-Lypoxigenase) Inhibition
Brune K et al. Rheumatology 2004;43(Suppl. 1):i16–i20
Hauser RA. Journal of Prolotherapy. 2010;(2)1:305-322
Smith HS et al. J Support Oncol. 2006 Jun;4(6):277-87

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Ways to Prolong HEALTHY Life
3. Keep Bones and Joints Healthy
– Prevention of Osteo-Arhthritis
e.g: Syk (Spleen tyrosine kinase) Inhibition
Syk is an important immune signaling modulator that regulates signaling in B
cells, mast cells, neutrophils and macrophages

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Ways to Prolong HEALTHY Life
4. Maintain Healthy Asthetics
– Skin, Hair, Nails
Collagen is important building block for bone, skin, hair and nail
health & makes up to 80% of the total proteins present in bone and
up to 75% of total skin tissue
Collagen is essential for beautiful skin, hair, and nails as well as
healthy bones & joints
Collagen production decreases 1% per year beginning at age 213 &
reduced level of collagen leads to poor bone quality eventually
leading to osteopenia or osteoporosis
Collagen
Viguet-Carrin S et al. Osteoporos Int. 2006;17(3):319-36
Schwartz SR et al. Clin Interv Aging. 2012;7:267-73
Shuster S. Med Hypotheses. 2005;65(3):426-32

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Ways to Prolong HEALTHY Life
4. Maintain Healthy Asthetics
– Skin, Hair, Nails
e.g.: ch-OSA (Choline Stabilized Orthosilicic Acid)
ch-OSA is clinically proven to activate
the biological pathways generating collagen

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Ways to Prolong HEALTHY Life
5. Maintain Immune Function
– Immunity / Immune function are an integral part
of living system as 3rd LINE of DEFENCE against
Infection

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Increasing Diseases…

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Problems with Altered Immunity: As Common as Common Cold
Ways to Prolong HEALTHY Life

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Overview of the Immune Response
Ways to Prolong HEALTHY Life
5. Maintain Immune Function

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Mechanisms of Defense: Cell Mediated Immunity
• T -Helper Cells (TH) Cells: Central role in immune
response.
• T -Cytotoxic Cells (Tc) Cells: Destroy target cells
• Delayed Hypersensitivity T (TD) Cells: Involved in Allergic
reaction and transplant rejection
• T Suppressor (Ts) Cells: May shut down immune
response
Ways to Prolong HEALTHY Life
5. Maintain Immune Function

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Immunity: Time Frame
Due to the formation of immunological memory, reinfection at later time points leads to a
rapid increase in antibody production and effector T cell activity. These later infections can
be mild or even inaparent.
Ways to Prolong HEALTHY Life
??

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Ways to Prolong HEALTHY LifeControl of Aging..

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To Live beyond 100 yrs
• Management of patient/life must extend
beyond diagnosis and treatment of disease.
• Should consider promotion of function and
prevention of decline.
• Must focus on improving the understanding
of the science of aging.
• Interdisciplinary care giving is needed achieve
this goal.

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To Live beyond 100 yrs
• A complex system of interacting approaches to
the restoration, management and optimization of
human health.
• Approaches have an ecological base,
environmentally, economically and socially viable
indefinitely.
• Approaches that work harmoniously both with the
human body and the non-human environment,
and which do not result in unfair or
disproportionate impacts on any significant
contributory element of the healthcare system.
Think of “Sustainable Health”….

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If they could Live for 100 years..

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Living Beyond 100 Years
Myth or Truth?
TRUTH….
YES, WE CAN Live beyond 100 yrs
If they could NOT Live for 100 years..

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Arise, Awake..
Stop Not Till the Goal is Reached..

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