1. A Novel Topical Transdermal Delivery System Mark S. Nestor, M.D., Ph.D. Pankaj Modi, Ph.D, M.D.

7. SEM-Photograph- 250x SEM-Photograph- 1000x

9. NTL4: The Next Generation Topical Anesthetic Optimized 4% Topical Lidocaine in a Unique Nano Technology Delivery System Results of Clinical Trials Comparing NTL4 to LMX4 Protocols N ° 10025 10025.1 Center for Clinical and Cosmetic Research (CCCR), Aventura, Florida Mark S. Nestor, M.D., Ph.D.

24. Efficacy Results: Subjective VAS Early Onset (5 Minutes) (N=6) N=6 N=6 N=6 p=0.045 p=0.309 p=0.643 d=0.61 (Large) d=0.27 (Small) X Axis: Time After Injection Y Axis: VAS Scale

25. Subjective Level of Pain Early Onset (5 Minutes) (N=6) P=0.079 LMX4 NTL4 Product_Randomization 4 3 2 1 0 Count Moderate Pain Mild Pain Minimal Pain No Pain Subject_Level_of_Pain Bar Chart

26. Subject Satisfaction Data: Overall Preference Early Onset (5 Minutes) (N=6) P=0.02 Preference Rates: NTL4 = 83% (5/6) LMX4 = 16% (1/6) No Preference = 0% (0/8)

27. Blinded Investigator’s Evaluation of Pain Early Onset (5 Minutes) (N=6) P=0.076 LMX4 NTL4 Product_Randomization 4 3 2 1 0 Count Mild Pain Minimal Pain No Pain Subject_Level_of_Pain Bar Chart

28. VAS Comparison: Onset Immediate Post Injection N=30 N=6 N=8 N=6 p=0.044 p=0.004 p=0.068 p=0.045 d=0.98 (Large) X Axis: Duration of Application Y Axis: VAS Scale

29. Results Combined Trials

33. Topical Hyaluronic Acid (HA)

38. Clinical Evaluation: Skin Roughness

39. Clinical Evaluation: Skin Hydration

40. Clinical Evaluation: Skin Elasticity

41. Clinical Evaluation: Skin Radiance

42. Clinical Evaluation: Smoothing Effect

43. Clinical Evaluation: Overall Efficacy

44. Subjective Evaluation: Elasticity and Tightness

45. Subjective Evaluation: Texture Improvement

46. Subjective Evaluation: Skin Hydration Improvement

47. Subjective Evaluation: Global Appearance Improvement

48. Subjective Evaluation: Overall Efficacy

49. 49

52. 33 BEFORE 33

63. Clinical Evaluation: Skin Roughness

64. Clinical Evaluation: Skin Hydration

65. Clinical Evaluation: Skin Elasticity

66. Clinical Evaluation: Skin Radiance

67. Clinical Evaluation: Smoothing Effect

68. Clinical Evaluation: Overall Efficacy

69. Topical BP Combination Acne

78. Clinical Photographs Baseline 4 weeks

79. Clinical Photographs Baseline 6 weeks

80. Clinical Photographs Baseline 3 weeks 6 weeks

81. Clinical Photographs Baseline 3 weeks 6 weeks

82. Topical Botulinum Neurotoxin Aesthetic

95. Topical Toxin Before After 10 days

96. Topical Toxin Before After 10 days

97. Topical Toxin Before After 10 days

98. Topical Toxin Before After 10 days

99. Topical Botulinum Neurotoxin Hyperhidrosis

104. Hyperhidrosis; Before and After ( at week 16)

105. Hyperhidrosis; Before and After ( at week 16)