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Idconference10 28final-091027054849-phpapp01
- 1. Case Presentation: Progressive Neurological Deficits in a Patient with HIV Jason Andrews Harvard Joint ID Conference October 28, 2009
- 13. Dr. Jeremy Abramson Cancer Center Massachusetts General Hospital Questions: What HIV-associated malignancies should be considered? What are the next steps in the work-up?
- 18. Moritz Kaposi (1872): “Idiopathic multiple pigmented sarcoma of the skin”
- 19. “ Rare Cancer Seen in 41 Homosexuals” New York Times
- 20. Dukers NH and Rezza G. AIDS 2003, 17:1717-1730
- 21. Butler LM, et al. JID 2009; 200:430-8.
- 24. Is the incidence of MCD increasing? Perhaps MCD not related to immune suppression; unlike KS, not associated with paucity of HHV8-specific CD8+ T cells Powles T, et al. Annals of Oncology 2009, 20:775-79.
- 26. 24 patients, Median Survival: MCD 44 months, PEL 6 months, Solid Lymphoma 22 days. Simonelli C, et al. J Med Virol 2009;81:888-896.
- 28. KS viral load correlates with KS clinical stage KS viral load is higher in patients with HIV Campbell TB, et al. CID 2003; 36:1144-51.
- 31. NHL Survival in HAART Era Bower MA, et al. Ann Int Med 2005; 143:265-273.
Editor's Notes
- progression of the enhancing mass involving the left CN V, possibly the posterior left cavernous sinus, with mass effect on the pons and left middle cerebral penduncle, with associated edema. There was also new enhancement of CN V within left internal auditory canal.
- KSHV is divided into 6 subtypes, A-E plus N, with A and C dominating in North America and Europe, B predominant in Sub Saharan Africa. The prevalence varies tremendously, from <5% in North America to >50% in Sub Saharan Africa. But maps like these have to be interpreted with caution due to considerable variation in the assays.
- There is extensive literature on modes of transmission, but little clarity has emerged. KSHV has been noted to be transmitted through sexual activity, deep kissing, organ transplant, and rarely mother to child. On top is the prevalence of KSHV in South Africa, bottom is in Uganda. HIV prevalence was roughly the same.