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Spinal Cord Injuries
Natangwe Shimhanda
12/11/2019
Overview
• Relevant Anatomy
• Facts/Definitions
• Mechanism and Classification
• Incomplete Spinal Cord Syndromes
• ASIA chart
• Management
• Steroids
• References
Dermatomes
Myotomes
• Segmental nerve root innervating a muscle
• Upper limb:
– C5 - Deltoid
– C6 – Wrist extensors
– C7- Elbow extensors
– C8 – long finger flexors
– T1- Small hand muscles
• Lower Limbs:
– L2 – hip flexors
– L3,4 – Knee Extensors
– L4,5-S1 – Knee Flexion
– L5- Ankle Dorsiflexion
– S1- Ankle Plantar Flexion
Facts
• Men 85% > women 15%
• TRAUMA (US)= MVA (40%), Violence (22%), Falls
(22%), Sports (8%)
• Non-trauma = malignancy, infection (TB, epidural
abscess), vascular
• Cord Injuries: Cervical = 60%, Thoracic = 30%,
lumbar = 4%, and Sacral = 2%
Demographics
• Bimodal distribution
– young individuals with significant trauma
– older individuals that have minor trauma compounded by
degenerative spinal canal narrowing
• It is estimated that 3-25% of all spinal cord injuries occur after
initial traumatic episode due to improper immobilization and
transport.
Pathophysiology
• primary injury
– damage to neural tissue due to direct trauma
(usually irreversible)
• secondary injury
– injury to adjacent tissue due to decreased
perfusion
– lipid peroxidation
– free radical / cytokines
– cell apoptosis
Spinal Cord Injury
• Spinal shock - transient loss of function below
the level of injury (rarely lasts for more than
48 hours)
• Neurogenic Shock - functional
sympathomectomy, ↓BP & ↓HR (not
responsive to IVH)
Classification
• Complete: Absence of sensory & Motor function in lowest
sacral segments after resolution of spinal shock
• Incomplete (preservation of any sensory or motor function –
esp. sacral sparing = big toe flexion, perianal sensation and
bulbocavernosus reflex)
Types Of Incomplete Injuries
• Central Cord Syndrome -
hyperextension
• Anterior Cord Syndrome –
flexion/rotation
• Brown-Séquard Syndrome – knife in
the back
• Posterior Cord Syndrome – rare.
Hyperextension/knife
• Cord Concussion = full resolution
within 48hrs
Central cord Syndrome
• Hyperextension
• Common in elderly with
preexisting Spondylosis
and cervical stenosis
• Motor: Arm > Leg
weakness
• Sensory: Arms>Legs
• Reflexes: may vary
• Usually sacral sensory
sparing
Anterior Cord Syndrome
• Anterior spinal artery
compressed by bone
fragments
• Primarily affects motor
– paralysis
(corticospinal tracts)
• Rarely involves dorsal
columns
• Can occur with AAA
Hyperflexion
Injuries
Oedema posteriorly.
Ruptured ligamentum flavum
and interspinous ligament.
Brown-Séquard
All ROUTES Lead to the Thalamus
• Penetrating Injuries or rotational or
fracture/dislocation
• Ipsilateral motor loss (corticospinal) &
proprioception
• Contralateral sensory (pain/temp) loss
(spinothalamic)
Posterior Cord Syndrome
• Rare
• Loss of proprioception
and vibration
• Good prognosis
• Penetrating back
trauma or
hyperextension – with
# vertebral arch
Cauda Equina Syndrome
• Not a cord syndrome. Technically a LMN lesion.
• LMN lesion = loss of knee reflexes. Leg weakness
• Bladder/bowel dysfunction
• Loss of anal tone
• Sexual dysfunction
• SCIWORA
– (spinal cord injury without radiological
abnormality)
• Dx = no bony or ligamentous injury on x-ray or
CT
– With MRI real “SCIWORA” is rare.
– There is usually cord/ligament injury on MRI
– More common in children – spine more flexible
and less likely to #
– Typically in the cervical region
Examination
• Primary survey first
• Cord and vertebral injuries will be picked up on 2° survey
• Head – toe approach
• Look – head, neck, mouth (prevertebral haematoma), paradoxical breathing, lap
seatbelt sign, gross deformity, priapism usually reflects a complete cord injury,
bilateral horner’s syndrome (>T1 and sometimes >T4)
• Feel – feel along the midline of the neck – feeling for deformity and areas of
maximal tenderness. Log Roll
• Examine each modality separately. Head – neck – upper limbs – torso – lower
limbs
• Motor – grading /5
• Sensory – soft touch (dorsal columns) and pain (spinothalamic). ?just pain?
• Reflexes – especially anal tone
• Documentation….
ASIA
Diagnostics
• XRAY (appropriate views)
• Myelography
• CT Scan
• MRI
Xrays
40 years old man with hx of
falling into a +/- 40m well,
Presented with no motor
activity below Knees,
Sensation is Intact but
reduced below the knees
as well
34 years male involved in an MVA, driver
unrestrained, presented with backpain.
O/E: no neurological fall out but there
was swelling and tendernerness around
L1
Initial Management
• Steroids (controversial)
• Neck Immobilization Collar
• Back Immobilization with back support
• Traction with weights and pulleys
Cochrane 2012
• Found that methylprednisolone within 8 hrs gave a
significant recovery of motor function
• Contraindications: heavily contaminated wounds,
bowel perforation , sepsis
• Considerations: Type 2 DM, peptic ulcer risk
Surgical Management
• Surgical Decompression
• Fixation/ stabilization with a steel rod
• External Immobilization with a brace/cast
Complications
• Immediate:
– Respiratory arrest
– Spinal shock
• Long term:
– Auttonomic dysreflexia
– Contractures
References
• Louis Solomon et al, 2010, Apley’s System of Orthopaedics
and fratures. 9th edition. Hodder Education
• Derek Moore, 2006. Spinal Cord Injuries. Updated:
8/9/2019.
https://www.orthobullets.com/spine/2006/spinal-cord-
injuries
• Members of the Orthopaedic Department at Oshakati State
Hospital, 2018. Intern Doctors Handbook by Orthopaedic
Department at IHO
• Bracken M, 2012. Steroids for Acute Spinal cord Injury.
Cochrane Review.
https://www.cochrane.org/CD001046/INJ_steroids-acute-
spinal-cord-injury

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Spinal cord injuries

  • 1. Spinal Cord Injuries Natangwe Shimhanda 12/11/2019
  • 2. Overview • Relevant Anatomy • Facts/Definitions • Mechanism and Classification • Incomplete Spinal Cord Syndromes • ASIA chart • Management • Steroids • References
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  • 8. Myotomes • Segmental nerve root innervating a muscle • Upper limb: – C5 - Deltoid – C6 – Wrist extensors – C7- Elbow extensors – C8 – long finger flexors – T1- Small hand muscles
  • 9. • Lower Limbs: – L2 – hip flexors – L3,4 – Knee Extensors – L4,5-S1 – Knee Flexion – L5- Ankle Dorsiflexion – S1- Ankle Plantar Flexion
  • 10. Facts • Men 85% > women 15% • TRAUMA (US)= MVA (40%), Violence (22%), Falls (22%), Sports (8%) • Non-trauma = malignancy, infection (TB, epidural abscess), vascular • Cord Injuries: Cervical = 60%, Thoracic = 30%, lumbar = 4%, and Sacral = 2%
  • 11. Demographics • Bimodal distribution – young individuals with significant trauma – older individuals that have minor trauma compounded by degenerative spinal canal narrowing • It is estimated that 3-25% of all spinal cord injuries occur after initial traumatic episode due to improper immobilization and transport.
  • 12. Pathophysiology • primary injury – damage to neural tissue due to direct trauma (usually irreversible) • secondary injury – injury to adjacent tissue due to decreased perfusion – lipid peroxidation – free radical / cytokines – cell apoptosis
  • 13. Spinal Cord Injury • Spinal shock - transient loss of function below the level of injury (rarely lasts for more than 48 hours) • Neurogenic Shock - functional sympathomectomy, ↓BP & ↓HR (not responsive to IVH)
  • 14. Classification • Complete: Absence of sensory & Motor function in lowest sacral segments after resolution of spinal shock • Incomplete (preservation of any sensory or motor function – esp. sacral sparing = big toe flexion, perianal sensation and bulbocavernosus reflex)
  • 15. Types Of Incomplete Injuries • Central Cord Syndrome - hyperextension • Anterior Cord Syndrome – flexion/rotation • Brown-Séquard Syndrome – knife in the back • Posterior Cord Syndrome – rare. Hyperextension/knife • Cord Concussion = full resolution within 48hrs
  • 16. Central cord Syndrome • Hyperextension • Common in elderly with preexisting Spondylosis and cervical stenosis • Motor: Arm > Leg weakness • Sensory: Arms>Legs • Reflexes: may vary • Usually sacral sensory sparing
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  • 18. Anterior Cord Syndrome • Anterior spinal artery compressed by bone fragments • Primarily affects motor – paralysis (corticospinal tracts) • Rarely involves dorsal columns • Can occur with AAA
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  • 22. All ROUTES Lead to the Thalamus
  • 23. • Penetrating Injuries or rotational or fracture/dislocation • Ipsilateral motor loss (corticospinal) & proprioception • Contralateral sensory (pain/temp) loss (spinothalamic)
  • 24. Posterior Cord Syndrome • Rare • Loss of proprioception and vibration • Good prognosis • Penetrating back trauma or hyperextension – with # vertebral arch
  • 25. Cauda Equina Syndrome • Not a cord syndrome. Technically a LMN lesion. • LMN lesion = loss of knee reflexes. Leg weakness • Bladder/bowel dysfunction • Loss of anal tone • Sexual dysfunction
  • 26. • SCIWORA – (spinal cord injury without radiological abnormality) • Dx = no bony or ligamentous injury on x-ray or CT – With MRI real “SCIWORA” is rare. – There is usually cord/ligament injury on MRI – More common in children – spine more flexible and less likely to # – Typically in the cervical region
  • 27. Examination • Primary survey first • Cord and vertebral injuries will be picked up on 2° survey • Head – toe approach • Look – head, neck, mouth (prevertebral haematoma), paradoxical breathing, lap seatbelt sign, gross deformity, priapism usually reflects a complete cord injury, bilateral horner’s syndrome (>T1 and sometimes >T4) • Feel – feel along the midline of the neck – feeling for deformity and areas of maximal tenderness. Log Roll • Examine each modality separately. Head – neck – upper limbs – torso – lower limbs • Motor – grading /5 • Sensory – soft touch (dorsal columns) and pain (spinothalamic). ?just pain? • Reflexes – especially anal tone • Documentation….
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  • 29. ASIA
  • 30. Diagnostics • XRAY (appropriate views) • Myelography • CT Scan • MRI
  • 31. Xrays 40 years old man with hx of falling into a +/- 40m well, Presented with no motor activity below Knees, Sensation is Intact but reduced below the knees as well
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  • 33. 34 years male involved in an MVA, driver unrestrained, presented with backpain. O/E: no neurological fall out but there was swelling and tendernerness around L1
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  • 38. Initial Management • Steroids (controversial) • Neck Immobilization Collar • Back Immobilization with back support • Traction with weights and pulleys
  • 39. Cochrane 2012 • Found that methylprednisolone within 8 hrs gave a significant recovery of motor function • Contraindications: heavily contaminated wounds, bowel perforation , sepsis • Considerations: Type 2 DM, peptic ulcer risk
  • 40. Surgical Management • Surgical Decompression • Fixation/ stabilization with a steel rod • External Immobilization with a brace/cast
  • 41. Complications • Immediate: – Respiratory arrest – Spinal shock • Long term: – Auttonomic dysreflexia – Contractures
  • 42. References • Louis Solomon et al, 2010, Apley’s System of Orthopaedics and fratures. 9th edition. Hodder Education • Derek Moore, 2006. Spinal Cord Injuries. Updated: 8/9/2019. https://www.orthobullets.com/spine/2006/spinal-cord- injuries • Members of the Orthopaedic Department at Oshakati State Hospital, 2018. Intern Doctors Handbook by Orthopaedic Department at IHO • Bracken M, 2012. Steroids for Acute Spinal cord Injury. Cochrane Review. https://www.cochrane.org/CD001046/INJ_steroids-acute- spinal-cord-injury

Editor's Notes

  1. Extends from the medulla oblongata to L1 Lower part is tapered to form the conus Medullaris
  2. Important in determining the level of the injury
  3. Most common at C5,6,7 due to greatest mobility at these levels The pt with a spinal cord injury will usually have other devastating injuries – therefore cord injuries are to be found on the secondary survey
  4. Steroids used to prevent secondary injury by improving perfusion, inhibiting lipid peroxidation, and decreasing the release of free radicals. IV dexamethasone 48mg stat, then 8mg tds for 2/7
  5. Neurogenic shock is produced by high spinal injury, which disrupts the sympathetic nerves controlling vasoconstriction. The peripheral vasculature relaxes and becomes profoundly dilated reducing preload and afterload. Even with increased cardiac output the patient cannot maintain an adequate BP/HR
  6. Cauda Equina Syndrome: Consists of lower limb weakness, absent reflexes, impaired sensation and urinary retention. Herniated Disc Syndrome: displacement of the disc with the escape cartliage
  7. upper extremity motor pathways are more medial(central) which explains why a central cord injury affects the upper extremities more than the lower extremities
  8. Vibration and Proprioception are Spared
  9. CES mainly affects middle-aged individuals, particularly those in their forties and fifties, and presents more often in men
  10. American Spinal Injury Association
  11. Non-haemorrhagic – high signal = oedema Haemorrhagic (low attenuation areas in the cord oedema Recovery is low in cases of cord hemorrhage compared to oedema Length of cord injury: long=bad
  12. IV dexamethasone 48mg stat, then 8mg tds for 2/7
  13. High-dose methylprednisolone steroid therapy is the only pharmacologic therapy shown to have efficacy in a phase three randomized trial when administered within eight hours of injury. One trial indicates additional benefit by extending the maintenance dose from 24 to 48 hours, if start of treatment must be delayed to between three and eight hours after injury. There is an urgent need for more randomized trials of pharmacologic therapy for acute spinal cord injury.