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Acta Scientific Neurology (ISSN: 2582-1121)
Volume 4 Issue 5 May 2021
Mental Well-being and Loneliness Among Residents of Karachi
During the Second Lockdown of COVID-19
Hina Zahoor* and Nasir Mustafa
School of Health Sciences, Istanbul Gelisim University, Turkey
*Corresponding Author: Hina Zahoor, Department of Health Sciences, Istanbul
Gelisim University, Turkey.
Research Article
Received: March 21, 2021
Published: April 28, 2021
© All rights are reserved by Hina Zahoor and
Nasir Mustafa.
Abstract
Background: Covid-19 emerged as a global pandemic and its catastrophic effects have been felt throughout the world. The pandemic
has caused a serious impact on mental health and loneliness of the people. The aim of the present research was to analyze the impact
of the Covid-19 on the psychological health of residents of Karachi during the second lockdown.
Method: It was a cross-sectional study conducted during the second wave of corona virus via an online survey, in which 380 persons
participated. The survey consists of questions for the assessment of symptoms of depression, anxiety, stress by using DAAS-21 scale
and for the questions related to loneliness, the UCLA-3 Item Loneliness Scale was used. Participants were selected by convenient and
snow ball sampling method.
Results: The results revealed that the psychological health was affected by the lockdown. It is also highlighted that women experi-
enced more stress, anxiety, and depression than men and there is also significant difference between men and women in terms of
loneliness.
Conclusion: During the second lock down in Karachi the residents suffered from moderate level of depression, severe level of stress
and mild level of anxiety. It is also evident that men have experienced less psychological impact of COVID 19 pandemic and with low
level of loneliness than women. The outbreak of this pandemic indicates the need to pay greater attention to this issue to prevent and
reduce the psychological outcomes of the pandemic.
Keywords: Covid -19; Stress; Anxiety; Depression; Loneliness; DASS-21; UCLA-3
Introduction
Within the last 20 years, several viral diseases have been re-
ported like Severe Acute Respiratory Syndrome (SARS) in 2003,
the H1N1 subtype of influenza virus in 2009, Middle East Respi-
ratory Syndrome (MERS) in 2012, and Ebola virus in 2014 [1,2].
On 31 December 2019, a novel Coronavirus type (2019-nCoV) was
detected as a causative factor in cases of pneumonia in the Chi-
nese city of Wuhan [3]. Later the virus, COVID-19, spread rapidly
around the globe and on the 30th of January, 2020 World Health
Organization declared international health emergency [4]. In re-
sponse to this global health emergency, strict measures have been
taken for the public safety and to prevent viral spread through
quarantines and public contact avoidance [5]. Quarantine relates to
the separation of men or animals in an effort to prevent the spread
of disease [6].
Research Studies found out that exceptional circumstances of
detention have caused psychological effect including loneliness and
higher levels of anxiety and stress [7-10]. These uncertain condi-
tions are also deemed as triggering elements for anxiety and de-
Citation: Hina Zahoor and Nasir Mustafa. “Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19".
Acta Scientific Neurology 4.5 (2021): 51-55.
pression in certain population sub-groups [11]. The isolation from
society caused mental and physical health issues and it is also evi-
dent that psychological health issues are more common in people
who are in quarantine [7]. This paper shed light on the effect of iso-
lation and uncertain conditions due to Covid 19 Pandemic on the
mental health status of individual in terms of stress, depression,
anxiety and spiritual well-being.
An additional research study conducted that a broad range of
psychological sequels have been observed during the outbreak of
Virus, from individual to international level, like the feeling of help-
lessness and the fear of death, which have been commonly expe-
rienced by individuals during an epidemic [12]. Researchers also
agreed on the assertion that the pandemic has affected people’s
mental health and it can turn into psychological problem, but the
early recognition of a psychological disorder makes the interven-
tion strategies more useful [13]. It is also observed that the recent
pandemic has affected the people’s psychological health not only
in health workers but also in general population and the causative
factors behind this are insecurity and fear [14].
Anxiousness and tension in the society affected each person
separately during this out break and it is evident that individual
in isolation faces high levels of anxiety, loneliness, and stress [3].
Moreover, the present situation of pandemic has increased health-
care needs whether one is inside or outside of his house. Families
are facing the strain of confinement; especially female members of
the families are affected most due to the burden of care they are
used to deal in such situation [15]. It is also reported that during
this critical period of social loneliness and separation amid CO-
VID-19, the cases of domestic violence have increased [16]. So it
is right to state that female members of society are more prone to
unwanted mental and physical burden of work [17].
There are few studies which have provided evidences on gender
related differences of COVID -19 impact on Psychological health is-
sues and feeling of loneliness under confinement [14,18-20]. More-
over, research study revealed a strong correlation between females
and feeling of loneliness during the Covid-19 pandemic [20]. But
no study so far has been conducted on the psychological impact
in terms of depression, stress, anxiety, and feeling of loneliness
among the residents of Karachi. The objective of the current cross
sectional study is to investigate the gender role in the psychologi-
cal impact of the Covid- 19 outbreak in Karachi during the second
wave of lockdown by using the variables mentioned in figure 1.
Methods
Study design
The cross sectional study was conducted between 22 November
to 6 December 2020 using online survey via social media platforms
through a google form link with the aim to access possible maxi-
mum population. Convenient and snow ball sampling techniques
were used to collect the data. The questionnaire consisted of 24
questions and the completion time required was about 3 minutes
[20].
Sample
To access the population’s sample, social networking channels
i.e. WhatsApp, Facebook and email were used considering conve-
nient sampling and then in addition snowball technique for further
data collection was adopted [18].
Participation criteria
Participants had to be over 18 years old and living in Karachi
during Covid-19.
Research instrument
Sociodemographic factors
It included age (18-25, 26-40, 41-60); gender (man, woman),
marital Status (single, married, divorced, widow), income (≤
35,000 PKR, 35,001 to 100,000 PKR, ≥ 100,000 PKR)
Feeling of loneliness
It was measured by the 3-item version of the UCLA Loneliness
Figure 1: Variables of study.
52
Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19
Citation: Hina Zahoor and Nasir Mustafa. “Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19".
Acta Scientific Neurology 4.5 (2021): 51-55.
Scale (UCLA-3). It is the shorter version of the original 20 question
instrument (UCLA Loneliness Scale, 2004)
Stress, anxiety and stress
To examine mental health, DASS-21 (Depression, Anxiety, and
Stress Scale) was used. It consists of 21 questions to assess de-
pression, anxiety and stress. This scale evaluates three negative
emotional states in an individual i.e depression, anxiety and stress.
These feelings were rated on a 4-point Likert scale which ranges
from 1-4 (It did not apply to me at all:1- It applied to me very much
or most of the time: 4). The sum of scores of depression, anxiety
and stress were then further categorized and classified as “normal”,
“mild”, “moderate”, “severe” or “extremely severe”.
Statistical analysis
Data was analyzed by IBM SPSS Version 21. The t test was con-
ducted to compare the means between men and women and sig-
nificance level p-value < 0.05 was chosen. For the evaluation of so-
ciodemographic features, questions were developed to collect data
on age, gender identity, marital status and income level.
Results
Sample characteristics
A total of 420 questionnaires were distributed out of which 380
were completed and considered as valid for analysis. Response
rate was 90.47% of confidence interval with 5% of margin of error.
Female participants were 230 while male were 150. Age groups:
18-25, 26-40, 41- 60. The age groups 26-40 showed the highest
response rates as compared to the other age groups. Sociodemo-
graphic characteristics of samples are shown in table 1.
Gender and DASS 21
The results regarding of the mean of anxiety, stress and depres-
sion with regards to gender are illustrated in table 2. Results of the
t-test showed that women experienced more anxiety, stress and
depression than men (P = 0.001).
Gender and anxiety
The anxiety score reached among both females (4.82 ± 3.95)
and males (3.43 ± 2.50) a significant level (P = 0.001).
Gender and stress
The stress score reached among both females (8.54 ± 4.65) and
males (6.52 ± 5.70) a significant level (P = 0.001).
Gender and depression
The depression score reached among both females (6.69 ± 3.21)
and males (4.43 ± 3.11) a significant level (P = 0.001).
Gender and UCLA-3
The loneliness score reached among both females (8.85 ± 4.96)
and males (3.44 ± 2.72) a significant level (P = 0.001) table 2. Illus-
trates DASS-21 Scores on gender basis and table 3 illustrates UCLA-
3 Scores on gender basis.
Variable
Gender
Male
Female
Age
18-25
26-40
41-60
Marital Status
Single
Married
Divorced
Widower
Income
≤ 35,000 PKR
35,001 to 100,000 PKR
≥ 100,000 PKR
n (%)
150 (39)
230 (65)
110 (29)
190 (50)
80 (21)
180 (47)
130 (35)
50 (13)
20 (5)
200 (52)
130 (35)
50 (13)
Table 1: Socio-demographic characteristics.
DASS 21 Score
Gender Anxiety Stress Depression
Female
Male
P value
4.82 ± 3.95
3.43 ± 2.50
0.001
8.54 ± 4.65
6.52 ± 5.70
0.001
6.69 ± 3.21
4.43 ± 3.11
0.001
Table 2: DASS-21 Scores on Gender basis.
Gender UCLA-3
Female (230)
Male (150)
P value
8.85 ± 4.96
3.44 ± 2.27
0.001
Table 3: UCLA-3Scores on Gender basis.
53
Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19
Citation: Hina Zahoor and Nasir Mustafa. “Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19".
Acta Scientific Neurology 4.5 (2021): 51-55.
Discussion
The present study is a contribution to the literature that pro-
vides evidence that Covid-19 affects the mental health in terms of
anxiety, stress depression and loneliness among the residents of
Karachi. The research data shows that during the second wave of
lockdown women were prominently affected in all studied vari-
ables. It was also observed that women’s levels of loneliness also in-
creased. On the contrary, men presented fewer depressive, anxious
symptoms, less loneliness and greater well-being in both measure-
ments. Women suffered a greater impact from the prolonged con-
finement (isolation) in all the studied variables. Studies revealed
that during lockdown women felt discomfort and suffered due to
overburden and increase demand of care in their daily life [23,24].
In Pakistan, this issue has already been under consideration, and
a survey was conducted during the outbreak of virus and more
than three hundred women were found with mental health issues.
Amazingly more than 90 women from this group had no previous
mental issues [25]. Research studies also noticed that incidents of
domestic violence have also increased during pandemic [16,26]. So
it is suggested to raise awareness of this particular situation and
there is a need to develop policies to diminish these harmful out-
comes [17]. Researchers offered a few suggestions in this regard
like decrease in the number of working hours, serve the needs of
single moms considering the work burden on females and there is
also need to increase awareness of gender inequalities [27].
The present study evaluated the gender based mental health
issues and loneliness among 380 residents of Karachi during the
second wave of Corona Virus using the DASS-21 and Loneliness
Scale (UCLA-3). Questionnaires. DASS-21 (Depression, Anxiety,
and Stress Scale) were used to examine mental health; the first
one includes 21 questions to assess depression, anxiety and stress
and the second one measures feeling of loneliness by the 3-item
version. The latter is a shorter version of the original 20 question
instrument (UCLA Loneliness Scale). The results indicated signifi-
cant differences between men and women’s levels of Depression,
Anxiety, and Stress and loneliness. Findings of the DASS-21 showed
gender status has a significant effect on depression, anxiety, and
stress values, depression and anxiety scores were higher in wom-
en than in men. Similarly, the results finding of UCLA Loneliness
(UCLA-3) showed that women experienced more loneliness than
men amid lockdown. Moreover, results indicated highest stress and
loneliness followed by depression and anxiety in women and men
in general.
The present research study has some limitations. Firstly, the re-
sults drawn from current study are on the basis of a cross sectional
study and the sample size was also limited. It does not reflect the
characteristics of whole population of Pakistan. Furthermore, this
research carried the data of only urban population and no infor-
mation regarding mental health issues of rural population. So the
future investigation is recommended at national level with large
sample size this regard.
Conclusion
The present study reveals the mental health issues and lone-
liness among men and women in Karachi. Greater psychological
impact of Covid-19 was noticed on women, with higher levels of
stress and feeling of loneliness, moderate level of depressive symp-
toms and mild levels of anxiety. Females in the age group (26- 40)
were more vulnerable in this regard. On the contrary, least psycho-
logical impact of the pandemic was observed on men in terms of
stress, depression, anxiety and loneliness. The outbreak empha-
sizes the need to pay more attention to the women to prevent and
mitigate the psychological outcome of the pandemic. In the light of
these findings necessary assistance should be provided via virtual
support teams and through awareness programs on social media to
reduce the psychological impact of pandemic.
54
Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19
Citation: Hina Zahoor and Nasir Mustafa. “Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19".
Acta Scientific Neurology 4.5 (2021): 51-55.
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Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19
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Acta Scientific Neurology 4.5 (2021): 51-55.
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Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19

  • 1. Acta Scientific Neurology (ISSN: 2582-1121) Volume 4 Issue 5 May 2021 Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19 Hina Zahoor* and Nasir Mustafa School of Health Sciences, Istanbul Gelisim University, Turkey *Corresponding Author: Hina Zahoor, Department of Health Sciences, Istanbul Gelisim University, Turkey. Research Article Received: March 21, 2021 Published: April 28, 2021 © All rights are reserved by Hina Zahoor and Nasir Mustafa. Abstract Background: Covid-19 emerged as a global pandemic and its catastrophic effects have been felt throughout the world. The pandemic has caused a serious impact on mental health and loneliness of the people. The aim of the present research was to analyze the impact of the Covid-19 on the psychological health of residents of Karachi during the second lockdown. Method: It was a cross-sectional study conducted during the second wave of corona virus via an online survey, in which 380 persons participated. The survey consists of questions for the assessment of symptoms of depression, anxiety, stress by using DAAS-21 scale and for the questions related to loneliness, the UCLA-3 Item Loneliness Scale was used. Participants were selected by convenient and snow ball sampling method. Results: The results revealed that the psychological health was affected by the lockdown. It is also highlighted that women experi- enced more stress, anxiety, and depression than men and there is also significant difference between men and women in terms of loneliness. Conclusion: During the second lock down in Karachi the residents suffered from moderate level of depression, severe level of stress and mild level of anxiety. It is also evident that men have experienced less psychological impact of COVID 19 pandemic and with low level of loneliness than women. The outbreak of this pandemic indicates the need to pay greater attention to this issue to prevent and reduce the psychological outcomes of the pandemic. Keywords: Covid -19; Stress; Anxiety; Depression; Loneliness; DASS-21; UCLA-3 Introduction Within the last 20 years, several viral diseases have been re- ported like Severe Acute Respiratory Syndrome (SARS) in 2003, the H1N1 subtype of influenza virus in 2009, Middle East Respi- ratory Syndrome (MERS) in 2012, and Ebola virus in 2014 [1,2]. On 31 December 2019, a novel Coronavirus type (2019-nCoV) was detected as a causative factor in cases of pneumonia in the Chi- nese city of Wuhan [3]. Later the virus, COVID-19, spread rapidly around the globe and on the 30th of January, 2020 World Health Organization declared international health emergency [4]. In re- sponse to this global health emergency, strict measures have been taken for the public safety and to prevent viral spread through quarantines and public contact avoidance [5]. Quarantine relates to the separation of men or animals in an effort to prevent the spread of disease [6]. Research Studies found out that exceptional circumstances of detention have caused psychological effect including loneliness and higher levels of anxiety and stress [7-10]. These uncertain condi- tions are also deemed as triggering elements for anxiety and de- Citation: Hina Zahoor and Nasir Mustafa. “Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19". Acta Scientific Neurology 4.5 (2021): 51-55.
  • 2. pression in certain population sub-groups [11]. The isolation from society caused mental and physical health issues and it is also evi- dent that psychological health issues are more common in people who are in quarantine [7]. This paper shed light on the effect of iso- lation and uncertain conditions due to Covid 19 Pandemic on the mental health status of individual in terms of stress, depression, anxiety and spiritual well-being. An additional research study conducted that a broad range of psychological sequels have been observed during the outbreak of Virus, from individual to international level, like the feeling of help- lessness and the fear of death, which have been commonly expe- rienced by individuals during an epidemic [12]. Researchers also agreed on the assertion that the pandemic has affected people’s mental health and it can turn into psychological problem, but the early recognition of a psychological disorder makes the interven- tion strategies more useful [13]. It is also observed that the recent pandemic has affected the people’s psychological health not only in health workers but also in general population and the causative factors behind this are insecurity and fear [14]. Anxiousness and tension in the society affected each person separately during this out break and it is evident that individual in isolation faces high levels of anxiety, loneliness, and stress [3]. Moreover, the present situation of pandemic has increased health- care needs whether one is inside or outside of his house. Families are facing the strain of confinement; especially female members of the families are affected most due to the burden of care they are used to deal in such situation [15]. It is also reported that during this critical period of social loneliness and separation amid CO- VID-19, the cases of domestic violence have increased [16]. So it is right to state that female members of society are more prone to unwanted mental and physical burden of work [17]. There are few studies which have provided evidences on gender related differences of COVID -19 impact on Psychological health is- sues and feeling of loneliness under confinement [14,18-20]. More- over, research study revealed a strong correlation between females and feeling of loneliness during the Covid-19 pandemic [20]. But no study so far has been conducted on the psychological impact in terms of depression, stress, anxiety, and feeling of loneliness among the residents of Karachi. The objective of the current cross sectional study is to investigate the gender role in the psychologi- cal impact of the Covid- 19 outbreak in Karachi during the second wave of lockdown by using the variables mentioned in figure 1. Methods Study design The cross sectional study was conducted between 22 November to 6 December 2020 using online survey via social media platforms through a google form link with the aim to access possible maxi- mum population. Convenient and snow ball sampling techniques were used to collect the data. The questionnaire consisted of 24 questions and the completion time required was about 3 minutes [20]. Sample To access the population’s sample, social networking channels i.e. WhatsApp, Facebook and email were used considering conve- nient sampling and then in addition snowball technique for further data collection was adopted [18]. Participation criteria Participants had to be over 18 years old and living in Karachi during Covid-19. Research instrument Sociodemographic factors It included age (18-25, 26-40, 41-60); gender (man, woman), marital Status (single, married, divorced, widow), income (≤ 35,000 PKR, 35,001 to 100,000 PKR, ≥ 100,000 PKR) Feeling of loneliness It was measured by the 3-item version of the UCLA Loneliness Figure 1: Variables of study. 52 Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19 Citation: Hina Zahoor and Nasir Mustafa. “Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19". Acta Scientific Neurology 4.5 (2021): 51-55.
  • 3. Scale (UCLA-3). It is the shorter version of the original 20 question instrument (UCLA Loneliness Scale, 2004) Stress, anxiety and stress To examine mental health, DASS-21 (Depression, Anxiety, and Stress Scale) was used. It consists of 21 questions to assess de- pression, anxiety and stress. This scale evaluates three negative emotional states in an individual i.e depression, anxiety and stress. These feelings were rated on a 4-point Likert scale which ranges from 1-4 (It did not apply to me at all:1- It applied to me very much or most of the time: 4). The sum of scores of depression, anxiety and stress were then further categorized and classified as “normal”, “mild”, “moderate”, “severe” or “extremely severe”. Statistical analysis Data was analyzed by IBM SPSS Version 21. The t test was con- ducted to compare the means between men and women and sig- nificance level p-value < 0.05 was chosen. For the evaluation of so- ciodemographic features, questions were developed to collect data on age, gender identity, marital status and income level. Results Sample characteristics A total of 420 questionnaires were distributed out of which 380 were completed and considered as valid for analysis. Response rate was 90.47% of confidence interval with 5% of margin of error. Female participants were 230 while male were 150. Age groups: 18-25, 26-40, 41- 60. The age groups 26-40 showed the highest response rates as compared to the other age groups. Sociodemo- graphic characteristics of samples are shown in table 1. Gender and DASS 21 The results regarding of the mean of anxiety, stress and depres- sion with regards to gender are illustrated in table 2. Results of the t-test showed that women experienced more anxiety, stress and depression than men (P = 0.001). Gender and anxiety The anxiety score reached among both females (4.82 ± 3.95) and males (3.43 ± 2.50) a significant level (P = 0.001). Gender and stress The stress score reached among both females (8.54 ± 4.65) and males (6.52 ± 5.70) a significant level (P = 0.001). Gender and depression The depression score reached among both females (6.69 ± 3.21) and males (4.43 ± 3.11) a significant level (P = 0.001). Gender and UCLA-3 The loneliness score reached among both females (8.85 ± 4.96) and males (3.44 ± 2.72) a significant level (P = 0.001) table 2. Illus- trates DASS-21 Scores on gender basis and table 3 illustrates UCLA- 3 Scores on gender basis. Variable Gender Male Female Age 18-25 26-40 41-60 Marital Status Single Married Divorced Widower Income ≤ 35,000 PKR 35,001 to 100,000 PKR ≥ 100,000 PKR n (%) 150 (39) 230 (65) 110 (29) 190 (50) 80 (21) 180 (47) 130 (35) 50 (13) 20 (5) 200 (52) 130 (35) 50 (13) Table 1: Socio-demographic characteristics. DASS 21 Score Gender Anxiety Stress Depression Female Male P value 4.82 ± 3.95 3.43 ± 2.50 0.001 8.54 ± 4.65 6.52 ± 5.70 0.001 6.69 ± 3.21 4.43 ± 3.11 0.001 Table 2: DASS-21 Scores on Gender basis. Gender UCLA-3 Female (230) Male (150) P value 8.85 ± 4.96 3.44 ± 2.27 0.001 Table 3: UCLA-3Scores on Gender basis. 53 Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19 Citation: Hina Zahoor and Nasir Mustafa. “Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19". Acta Scientific Neurology 4.5 (2021): 51-55.
  • 4. Discussion The present study is a contribution to the literature that pro- vides evidence that Covid-19 affects the mental health in terms of anxiety, stress depression and loneliness among the residents of Karachi. The research data shows that during the second wave of lockdown women were prominently affected in all studied vari- ables. It was also observed that women’s levels of loneliness also in- creased. On the contrary, men presented fewer depressive, anxious symptoms, less loneliness and greater well-being in both measure- ments. Women suffered a greater impact from the prolonged con- finement (isolation) in all the studied variables. Studies revealed that during lockdown women felt discomfort and suffered due to overburden and increase demand of care in their daily life [23,24]. In Pakistan, this issue has already been under consideration, and a survey was conducted during the outbreak of virus and more than three hundred women were found with mental health issues. Amazingly more than 90 women from this group had no previous mental issues [25]. Research studies also noticed that incidents of domestic violence have also increased during pandemic [16,26]. So it is suggested to raise awareness of this particular situation and there is a need to develop policies to diminish these harmful out- comes [17]. Researchers offered a few suggestions in this regard like decrease in the number of working hours, serve the needs of single moms considering the work burden on females and there is also need to increase awareness of gender inequalities [27]. The present study evaluated the gender based mental health issues and loneliness among 380 residents of Karachi during the second wave of Corona Virus using the DASS-21 and Loneliness Scale (UCLA-3). Questionnaires. DASS-21 (Depression, Anxiety, and Stress Scale) were used to examine mental health; the first one includes 21 questions to assess depression, anxiety and stress and the second one measures feeling of loneliness by the 3-item version. The latter is a shorter version of the original 20 question instrument (UCLA Loneliness Scale). The results indicated signifi- cant differences between men and women’s levels of Depression, Anxiety, and Stress and loneliness. Findings of the DASS-21 showed gender status has a significant effect on depression, anxiety, and stress values, depression and anxiety scores were higher in wom- en than in men. Similarly, the results finding of UCLA Loneliness (UCLA-3) showed that women experienced more loneliness than men amid lockdown. Moreover, results indicated highest stress and loneliness followed by depression and anxiety in women and men in general. The present research study has some limitations. Firstly, the re- sults drawn from current study are on the basis of a cross sectional study and the sample size was also limited. It does not reflect the characteristics of whole population of Pakistan. Furthermore, this research carried the data of only urban population and no infor- mation regarding mental health issues of rural population. So the future investigation is recommended at national level with large sample size this regard. Conclusion The present study reveals the mental health issues and lone- liness among men and women in Karachi. Greater psychological impact of Covid-19 was noticed on women, with higher levels of stress and feeling of loneliness, moderate level of depressive symp- toms and mild levels of anxiety. Females in the age group (26- 40) were more vulnerable in this regard. On the contrary, least psycho- logical impact of the pandemic was observed on men in terms of stress, depression, anxiety and loneliness. The outbreak empha- sizes the need to pay more attention to the women to prevent and mitigate the psychological outcome of the pandemic. In the light of these findings necessary assistance should be provided via virtual support teams and through awareness programs on social media to reduce the psychological impact of pandemic. 54 Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19 Citation: Hina Zahoor and Nasir Mustafa. “Mental Well-being and Loneliness Among Residents of Karachi During the Second Lockdown of COVID-19". Acta Scientific Neurology 4.5 (2021): 51-55. Bibliography 1. Mustafa N., et al. “İnsan-COVID-19’da Pandemik SARS coro- navirus-2 Enfeksiyonları”. İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi 10 (2020): 77-93. 2. S Kisely., et al. “Occurrence, prevention, and management of the psychological effects of emerging virus outbreaks on healthcare workers: rapid review and meta-analysis”. BMJ (2020): 369. 3. 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