Precision Medicine at MSU
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Use of personalized 'omics' George I. Mias Department of Biochemistry and Molecular Biology 10/29/2015
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Precision Medicine at MSU
- 1. Department of Biochemistry and Molecular Biology George I. Mias gmias@msu.edu Precision Medicine Forum G. Mias Lab I O
- 2. gmias@msu.edu ‣ “I want the country that eliminated polio and mapped the human genome to lead a new era of medicine — one that delivers the right treatment at the right time. In some patients with cystic fibrosis, this approach has reversed a disease once thought unstoppable. Tonight, I'm launching a new Precision Medicine Initiative to bring us closer to curing diseases like cancer and diabetes — and to give all of us access to the personalized information we need to keep ourselves and our families healthier.” (President Barak Obama, State of the Union, 2015) Precision Medicine Initiative G. Mias Lab I O
- 3. gmias@msu.edu Precision Medicine ‣ Complete personalized omics ‣ integrative Personal Omics Profiling Chen*, Mias GI*, Li-Pook- Than*, Jiang* et al Cell 148, 1293–1307 (2012) Resource Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes Mias & Snyder, Quantitative Biology (1)1 p72 (2013) http://goo.gl/iamZthG. Mias Lab I O
- 4. gmias@msu.edu MSH6 H2AFX RAD50 HIST2H2AB NAP1L4 MSH3 OBFC2B EXOSC6 PDIA3PNPT1 HIST1H1E TAP2 ITSN2 TAP1 TBL3 TERF1 WDR3 UTP15 DIS3 HIST1H1B EXOSC8 HIST1H4A EXOSC9 NDUFC2 NDUFS7 NDUFA2NDUFB7 NDUFB8 NDUFA3 NDUFS2 NDUFA10 KRR1 CLPP TUFM MDH2 SLC25A11 ACO2 PMPCA PMPCB NDUFB6 NDUFB3 NDUFS6 NDUFV3 NDUFA8 NDUFB9 NDUFB10 MRPS12 IDH3B SCAND1 ATP5B ATP5J ATP5I ATP5F1 ATP5HATP5A1 CS SLC25A4 RNF2 UQCRB UQCRC2 PCGF6 CYCS MYST1 UQCRQCOX5A COX6B1 ATP5G3 UQCRC1 COX5B COX4I1 COX6C NDUFB1 NDUFB5 NDUFV1 NDUFA11 NDUFB4 NDUFA5 PCGLUD1 NAGA LMNA GOT2TMPOLMNB1ATP6V1G1 PHKB GINS2 GINS4 GINS1 PIGH PIGC ATP6V1E1PIGP ATP6V0E1 FBXO5 RNF14 C1GALT1 NUCB2 SNX17 NOP2 LDLR CUL4A CUL4B PDCD11 SPATA5 NUP37 HSPD1 SNRPN HMGA1 KIN NUP153 TAF4B RARG NUP85 CDC5L CORO2A CPSF7 HNRNPF DHX9 HNRNPH2SNRPESNRPG SNRPD2 HNRNPUL1 TOMM40 MED28 DDX50 PHAX LSM4 NUP160 POLR2I NUP98 TAF12 NUP35 SEH1L NUP210 NUTF2 ERH HSPE1 CPSF1 TOMM20NUP62 CPSF2 CDC40 ZRSR2 HMGN4 SMC3 DIABLO SMC4 SUMO2 TNFSF14 CENPQ NSL1 CCDC99 BUB1 NDEL1 UBE2V2 PPID MED21 CENPH CENPF BIRC5 BCAS2 CENPN CBX1 BANF1 NUP155 PLRG1 NUP93 NUP54 EFHA1 MED7 NFX1 MED31 MED4 VDAC1 RCC1 ATF7 DHFR SMARCE1 CHAF1AWWOX TP53 CDK2 TP53RK FSTLBR BMPR1A ZMAT3 SMARCC2HMGB1 PARP1 PML ERCC4 CACYBP H3F3A ERBB2IP SNW1 TRIM24 UBE2E1 ANAPC5 PSMB2 PTTG1 BTG1 CDC14A ANAPC10 CDC27 FBXW7 TDG CDH2 REST PSMC6 UBE2D1 RBX1 RBPJ PAWR CAP1 SIAH1 STAG2 PRDX3 TCEB1 AURKB RAD21 CBX3 AIFM1 TRIM33 NCOA4 CUL5 ARVCF CBX5 XIAP BUB3 PDS5A PDS5B FBLPSMA7 PSMB10 ANP32E PSMA2 PSMA6 PSMA1 RIF1 PHF17 RANBP3 CDKN1C GZMK GZMA GZMH POLB CHD9 TOB1 CDK6 LEF1 HMGB2 ACADM CCNB1 POU5F1 MRPL11 SCP2 LIG3 LITAF UBE2M MBD4 XPA SKIL UBE2R2HES6 DDB2 DNAJA3 CCNG1 RPA3 PAX5 ING2 TCF4CDKN2CTTF1 MYST4 H1FX H1F0 DUT SMARCD2 ACSL3 HES1 CDKN2A RUNX2 TBRG1 POLD1 NOLC1 E2F3 CCND2 CCNA2 PRIM2 HELLS TOP1 FEN1 ACAA2 EBF1 ECHS1 RFC1 TCEAL1 ING4 RFC5 PNKP NEURL2 COIL MCM8 DBF4 SESN1 WRNIP1 HIST2H3ARRM2 NDN EI24 BCCIP TOPORS COPS3 KLF6 ARID2 RFWD2 YIPF5 NFKB2 RAB1A REL PKN2 UBE2V1 NFKBIE TLR9 NKRFNFE2L2 RALBP1 THEM4 MAP4K3 PTPN2FYN RTN4 HCFC1 TSC22D3 RAC1 PTPRC INSR MECP2 TRAF3IP3 PDPK1 SIN3A CARD11 CRK MAP3K3 CCAR1PRPF6 PCBP2 SF3B3 PDCD7 HNRNPA3 NONO RBM17 PRPF40A TRAP1 RBM42 DDX1 GCC2 SRPK2 HMGN1 POLR2A POLR2C HNRNPCSNRPD1 RANBP2 SNRPD3 UPF3A SNRNP200 HNRNPDSF3B4 CSTF3PRPF4 SF3A3 SF3A1 PTBP1 SNRPB2 NHP2L1 UPF3B HNRNPL CD2BP2 NUDT21 DCP1A SNRPA1 PHF5A SF3A2 SMNDC1 TOMM70A SNRPA HNRNPK SRRM1 SF3B1 PSIP1 RNPS1 GTF2F2 SON UBXN4 WAC PRPF4B MATR3 JMJD1C SYNCRIP DDX5 YTHDC1 HNRNPH3 KIAA0776 WBP4 CPSF6RBM39 UPF2QKI BZW1 AHSA1 TRA2A XRN2 RB1CC1 EIF4A3 CSNK1E PNNMETAP2BCLAF1 HSP90AA1 PIF1 KTN1 RBM25 PPIGARID4B RPL6 ZNF292 ZBTB1 SEC62 NKTR PPIL3 EIF4G1 EIF4G3 SLU7 EIF1AX HNRPLL REEP5 GOLGA4 EIF5B RPL10A RPL19 RPL36A EIF6 PIK3C2A RSBN1 CEP164 ARF4 CEP135 SAR1B CEP152 CEP290CEP63 CENPJ TUBGCP2 AKAP9 BRSK1 KLRD1 PFDN4 PPIB KLRC2 KLRC3 KIR2DS4 SLC3A2 BSG VBP1ATP1B3 SLC16A1 KLF10 SATB1 RAB13 PA2G4 LNPEP ARID4AIKZF4 GLG1 PRNP CYBB PFDN2 KLHL20 HCST CYBA IL10RB CSF2RA AGRN PELP1 IRS2 SOCS7 PIK3R5 BAIAP2 MYBL1 ITGAL RHOGIGF2R RHOQ KDELR1 PDK1 VAMP2 AKT1S1 RHOT1 GDI2 CHD6 CD79ACD86 RUVBL2 FAIM3 SPTAN1CXCR4 IGJ ELP4 CD74LST1 SHC1 PIK3CBSOCS2 ENAH CD247 LAX1 LPP CXCR6 SPN HRH2 GNG5 ACP1 IL18 GNAS FYB TYROBP DPP4 SKAP2 CALD1 GPR183 PLA2G6HLA-DRB1 EFNA1 PAG1 GNAI2 MARCKS ADAM15 PFN2 CCL5NEK9 GRAP ING3 YEATS4 MORF4L1 DMAP1 TPM1 DHTKD1 OGDH LMO4 PDPR PDHX PDHB PDP2 FGD4 ARHGEF18 ARHGAP4ARHGAP24 ARHGAP11B G3BP2 ITSN1 CDC42EP3 DLAT ZNF321 ZNF642 ZNF789 ZNF675 ZNF763 ZNF22ZNF354A ZNF100 ZNF404 ZFP30 ZNF737 ZNF254 ZNF564 ZNF275 ZNF20 ZNF708 ZNF680 ZNF793 ZNF107 ZNF493 ZNF709 ZNF714 ZNF286A ZNF140 ZNF626 ZFP14 ZNF514 ZNF14 ZFP82 ZNF264 RDX ZNF345 ZNF3 SLC9A3R2 ASH2L BAZ2B MBD2 SIGIRR EEA1 CUX1 ZNF441 ZNF485 ZNF324 ZNF320ZNF554 ZNF563 ZNF530ZNF91 ZNF222 ZNF268 ZNF429 BCAP31 ZNF32 ZNF480 ZNF117 ZNF44 ZNF43 ZNF184 ZNF426 BCAP29 ZNF146 ZNF439 ZNF791 SNAP23 RAB3GAP2 ZNF83 VIM PRKX YES1 FGR ADD1 CDV3 CNOT2 PNRC2 KIF5B SUB1 KIF5C SUZ12 KHDRBS1 CLK1NPM1 PPP2R5D PPP2R5C YWHAZMAP2K7 YWHAB RAF1 MAP4K4 BAZ1A NCK2 MAP3K7 IFI16 DDX41 ETV6 FBXW11 AXIN2 PSENEN FOXO3 POU2F2 MYH10 CSNK1G2 PPP2R2B CREB1 TLE3 HLA-DQB1 NEK8 MARK3 SAP18 ROCK1 LCK PRKCB PRKY TRIM22 NEDD9 PPARD SP110 ZNFX1 IKBKAP GYG1 BDP1 SNAPC1 SPTBN1 FDXR SQSTM1 TOP2A SSB PEBP1 NFYA DNAJC2 TBPL1 RERE PRF1 CAPN1 RUVBL1 GYS1 ADD2 POLR3A HIPK2 POU2F1 SP100 POLR3F MAPK7 GADD45A LDHA UBE2D3 NFIC ME2 CTCF HSPA9 SIAH2 BAZ1B STRADB MAF FABP3 RAD1 CAMK2D NFATC3 RUNX3 ID2 MYST2 GATA3 CTSC GTF2B DDX46 TCERG1 DEK TBL1X HDAC9 RBM14 TGS1 NXF1 PCNP PDCD10 IRF3 SNCA PPARA PTCH1 SMAD3 CORO7 MEF2C SMAD1 ZBTB44 SSR3 SEC61B SPCS2 SRP19 SSR4 SPCS3 SRPRB SPCS1 STT3B SRPR SRP14 EIF5 EIF3J EIF4B RPS28 TSGA14 DYNC1I2 FGFR1OPSDCCAG8 TUBGCP4 CEP250 CETN2 TMEM126B PABPC4 GSPT2 SEC63 RPL12RPL35 RPL18A RPS15RPS15A VAMP8 CHD4 RAB27A OFD1 RPH3AL GATAD2B AP1S3 integrative Personal Omics Profiling I. II. III. INTEGRATION OF MULTIPLE OMICS AND TEMPORAL RESPONSES MATCHED AGAINST iPOP DATABASES iPOP Database LONGITUDINAL OMICS PROFILING OF MULTIPLE PHYSIOLOGICAL STATESRISK EVALUATION Transcriptomics Whole Genome Sequencing Medical History & Environment Metabolomics Proteomics Disease Risk Evaluation Autoantibodyomics Microbiomics Clinical Tests Infected RecoveryHealthy New omics Healthy Pharmacogenomic Evaluation 5 10 15 1.0 0.5 0.5 1.0 t Mias & Snyder, Quantitative Biology (1)1 p72 (2013) http://goo.gl/iamZth G. Mias Lab I O
- 5. gmias@msu.edu Future Directions ‣ Precision Medicine at Michigan State • Precision Pediatrics (with Dr. Keith English) • Maternal Infant Precision Medicine (with Dr. Richard Leach) ‣ Personalized Medicine Center for the MidWest at MSU ‣ Training of Personnel [Essential, particularly our graduate students at MSU] ‣ Core Facilities [maintain and upgrade] ‣ Clinical Involvement [Integration of Central, Grand Rapids Campuses and Beyond] ‣ Campus Partnerships for True Collaboration ‣ Responsive to Public and Funder’s Expectations for Precision Medicine Initiative by White House and NIH G. Mias Lab I O