Montelukast is a selective and orally active leukotriene receptor antagonist that inhibits the Cysteinyl leukotriene CysLT1 receptor. Each 10 mg film-coated Loctril tablet contains 10.4 mg Montelukast sodium, which is equivalent to 10 mg of Montelukast.
4. What is Asthma ?
Asthma is a chronic disease involving the airways in the
lungs. These airways or bronchial tubes, allow air to come in
and out of the lungs.
If you have asthma your airways are always inflamed. They
become even more swollen and the muscles around the
airways can tighten when something triggers your symptoms.
This makes it difficult for air to move in and out of the lungs.
According to American Academy of Allergy Asthma & Immunology (AAAAI)
6. Asthma Triggers
Outdoor allergens- such as pollens from grass, trees and weeds
Indoor allergens- such as pet dander, dust mites and mold
Certain drugs and food additives
Irritants in the air- such as smoke, chemical fumes and strong
odors
Colds, the flu or other illnesses
Exercise
Stress
Weather conditions- such as cold air or extremely dry, wet or
windy weather
7. • Exercise-induced asthma is triggered by exercise or
physical exertion.
Many people with asthma experience some degree of
symptoms with exercise. With exercise-induced
asthma, airway narrowing peaks 5 to 20 minutes
after exercise begins
Exercise-Induced Asthma
8. Aspirin-induced Asthma
Taking aspirin or other NSAIDs (non-steroidal anti-
inflammatory drugs) triggers an asthma.
Between 2% and 25% of adults with asthma are
sensitive to aspirin.
Aspirin-induced asthma is more common in adults than
children.
This type of asthma is usually severe.
9. This asthma type accounts for nearly 60 percent of all
asthma. It involves airway obstruction and typical
asthma symptoms often associated with allergies and
triggered by allergens. Examples of common triggers
include pollens, molds, dust mites and animal dander.
Allergic Asthma
10. Night time asthma, also called nocturnal asthma,
is a common type of the disease. If you have
asthma, the chances of having symptoms are
much higher during sleep because asthma is
powerfully influenced by the sleep-wake cycle
(circadian rhythms). Your asthma symptoms of
wheezing, cough, and trouble breathing are
common and dangerous, particularly at
nighttime.
Night time (Nocturnal) Asthma
12. An allergen that causes an allergic reaction.
Allergic rhinitis, is an allergic response to specific
allergens. Pollen is the most common allergen in
seasonal allergic rhinitis. These are allergy
symptoms that occur with the change of
seasons.
What is Allergic Rhinitis?
19. Montelukast is a selective and orally active leukotriene
receptor antagonist that inhibits the Cysteinyl leukotriene
CysLT1 receptor. Each 10 mg film-coated Loctril tablet
contains 10.4 mg Montelukast sodium, which is
equivalent to 10 mg of Montelukast.
Loctril Tablet
20. Montelukast is A Potent Leukotrienes Receptor Antagonist
Anti Asthmatic
Therapeutic Class of Loctril Tablet
21. Leukotrienes are a naturally occurring chemical substance
(Autacoids) that promotes an inflammatory response.
When produced and released in the body, this chemical causes
airway constriction, the tightening of muscles and excess mucus
and fluid.
What are Leukotrienes?
22. When Leukotrienes are Released?
If anyone breathe an asthma triggers, the body of asthmatics
person release Leukotrienes.
23. Mechanism of Action of Loctril
Phospholipids
Arachidonic acid
COX
(Cyclooxy
genase)
5-lipooxygenease
PG
Thromboxane
LeukotrienesLeukotrienes
Binds with Leukotriene
Receptor
LoctrilLoctril
1. Causes bronchoconstriction
2. Increases mucus secretion
3. Increases Vascular permeability
4. Causes edema
Asthma
Binds with Cystinyl
Leukotriene receptor that
inhibits Asthma symptoms
25. Dosage and administrations
For asthma - Take once daily in the evening:
One 10-mg tablet for adults and adolescents 15 years of age and
older
For exercise-induced asthma - Take at least 2 hours before
exercise, but not more than once daily:
One 10-mg tablet for adults and adolescents 15 years of age and
older.
For allergic rhinitis - Take once daily at about the same time each
day:
One 10-mg tablet for adults and adolescents 15 years of age and
older
27. Product Brief
Product
Name
Generic Name Strength
Dosage
Form
Pack
Size
TP TP+VAT
MRP/
box
MRP/
Tablet
Loctril®
Montelukast 10 mg Tablet 10X3 339.58 393.91 453.00 15.10
28. Dear Sir/Madam
In this visual you are
watching that a fish is
facing challenge to
take breathe due to
lack of watery
environment
like that it is also
challenge to prevent
the root cause of
Asthma & Allergic
Rhinitis
39. Speciality Wise:
1. Chest Specialist
2. Medicine Specialist
3. Cardiologist
4. ENT Specialist
5. Skin & VD Specialist
6. GP
7. Doctor Cum Chemist
8. RMP
Target Doctors of Loctril
40. Ans: The pathophysiology processes of asthma may also increase
the risk of other disease involving inflammatory processes, such as
cardiovascular disease (eg.) atherosclerosis by generating
inflammatory biomarker CRP (Carbon reactive protein), IL-6
(Interleukin 6), LDL-C (Low density lipoprotein C), triglyceride etc.
Asthma patients are
43% more likely to have heart disease than non-asthmatics.
36% more likely to have high blood pressure than non-asthmatics.
Montelukast Lowers the CVD risk of asthma patients.
So, Loctril is the suitable treatment option for cardiologist.
Why Montelukast can be the suitable option for Cardiologist?
41. • Effectively blocks Cystinyl Leukotriene receptor
• Significantly reduces Day and Night time Asthma
symptoms
• Effectively reduces Allergic rhinitis symptoms
• Better than Salmeterol in bronchodilation
Unique selling point
42. • Ensure adequate shelving of Loctril®
tablet in front of nearest
all chemist shops, clinics and institutions of the targeted
doctors.
• Give special emphasis to the Chest Specialist, Medicine
Specialist because they have greater scope of prescribing
Loctril®
.
• Ensures effective outcome of Loctril®
samples by ensuring
huge number of prescriptions from every potential
prescribers.
• Focus should be given to RMPs, PCs as there is also huge
opportunities to generate Rx and sales from these physicians.
Actions to be taken
43. • Strong monitoring over the prescribers of Monas (Acme),
Montair (Incepta), Provair (Unimed), M-kast (Drug Int), Trilock
(Opsonin), Telukast (General), Lumona (Eskeayf), Reversair
(ACI), Montene (Square), Aeron (Healthcare), Monocast
(Beximco), Montril (Aristo), Odmon (Renata) and convince
them to prescribe Loctrol®
.
Actions to be taken