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By Maria Aoun




Maria AOUN   5/22/2012
Leukemia   is the cancer of
 the white blood cells.



         Maria AOUN   5/22/2012
   White blood cells help your body fight
    infection. Your blood cells form in
    your bone marrow.



   In leukemia however, the bone
    marrow produces abnormal white
    blood cells.


       Maria AOUN   5/22/2012
Maria AOUN   5/22/2012
Morphology of blood cells in leukemia
          Maria AOUN   5/22/2012
Four types of leukemia:

   -Acute lymphocytic leukemia
   -Acute myeloid leukemia
   -Chronic lymphocytic leukemia
   -Chronic myeloid leukemia


                 Maria AOUN   5/22/2012
Maria AOUN   5/22/2012
   Common symptoms:            Other symptoms:

.Fever or chills             .petechia (tiny red spots
.weakness and fatigue          under the skin)
.frequent infections         .swollen or bleeding
.weight-loss                   gums
.swollen or tender lymph     .sweating (especially at
   nodes                       night)
.easy bleeding or bruising   .bone or joint pain



                             Maria AOUN   5/22/2012
   Chemotherapy
   Other drug therapy and radiation
   Bone marrow and blood stem cell
    transplantation




                           Maria AOUN   5/22/2012
.Chemotherapy
.radiation therapy
.stem cell transplants
.infusion of donated white blood cells following
stem cell transplants
.immune therapy
.surgery to remove the spleen.



                           Maria AOUN   5/22/2012
Clonal expansion and accumulation of greater
than 20% leukemic myeloid blasts in the blood
or bone marrow .




                       Maria AOUN   5/22/2012
Malignancy of children and adults
characterized by the monoclonal
proliferation and accumulation of immature
lymphoid cells in the bone marrow, blood,
lymph nodes, and other organs including
spleen, liver, and CNS.




                      Maria AOUN   5/22/2012
A clonal myeloproliferative disorder resulting in the
overproduction and over-proliferation of Philadelphia
chromosome-positive myeloid cells.




                                  Maria AOUN   5/22/2012
Maria AOUN   5/22/2012
   For more information, click here.




                      Maria AOUN   5/22/2012
Maria AOUN   5/22/2012
Bibliography

Journal Articles

Flis K, Irvine D, Copland M, Bhatia R, Skorski T. Chronic myeloid
leukemia stem cells display alterations in the expression of genes
involved in oxidative phosphorylation. Leuk Lymphoma. 2012 May 23.
[Epub ahead of print] PubMed PMID: 22616753.

Other (Non-standard citation)

. The patient education institute. x-plain leukemia. 2010 April 02.
Medline plus.

.National Institutes of Health. Childhood Leukemia. 2010.Medline plus.

.Current Medicine LLC. acute lymphoblastic leukemia blasts. 2005.
Images MD.

.Diseasedex. Acute myeloid leukemia. 2000. Micromedex.


                                              Maria AOUN   5/22/2012
Bonus




        Maria AOUN   5/22/2012

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Power point maria aoun

  • 1. By Maria Aoun Maria AOUN 5/22/2012
  • 2. Leukemia is the cancer of the white blood cells. Maria AOUN 5/22/2012
  • 3. White blood cells help your body fight infection. Your blood cells form in your bone marrow.  In leukemia however, the bone marrow produces abnormal white blood cells. Maria AOUN 5/22/2012
  • 4. Maria AOUN 5/22/2012
  • 5. Morphology of blood cells in leukemia Maria AOUN 5/22/2012
  • 6. Four types of leukemia: -Acute lymphocytic leukemia -Acute myeloid leukemia -Chronic lymphocytic leukemia -Chronic myeloid leukemia Maria AOUN 5/22/2012
  • 7. Maria AOUN 5/22/2012
  • 8. Common symptoms:  Other symptoms: .Fever or chills .petechia (tiny red spots .weakness and fatigue under the skin) .frequent infections .swollen or bleeding .weight-loss gums .swollen or tender lymph .sweating (especially at nodes night) .easy bleeding or bruising .bone or joint pain Maria AOUN 5/22/2012
  • 9. Chemotherapy  Other drug therapy and radiation  Bone marrow and blood stem cell transplantation Maria AOUN 5/22/2012
  • 10. .Chemotherapy .radiation therapy .stem cell transplants .infusion of donated white blood cells following stem cell transplants .immune therapy .surgery to remove the spleen. Maria AOUN 5/22/2012
  • 11. Clonal expansion and accumulation of greater than 20% leukemic myeloid blasts in the blood or bone marrow . Maria AOUN 5/22/2012
  • 12. Malignancy of children and adults characterized by the monoclonal proliferation and accumulation of immature lymphoid cells in the bone marrow, blood, lymph nodes, and other organs including spleen, liver, and CNS. Maria AOUN 5/22/2012
  • 13. A clonal myeloproliferative disorder resulting in the overproduction and over-proliferation of Philadelphia chromosome-positive myeloid cells. Maria AOUN 5/22/2012
  • 14. Maria AOUN 5/22/2012
  • 15. For more information, click here. Maria AOUN 5/22/2012
  • 16. Maria AOUN 5/22/2012
  • 17. Bibliography Journal Articles Flis K, Irvine D, Copland M, Bhatia R, Skorski T. Chronic myeloid leukemia stem cells display alterations in the expression of genes involved in oxidative phosphorylation. Leuk Lymphoma. 2012 May 23. [Epub ahead of print] PubMed PMID: 22616753. Other (Non-standard citation) . The patient education institute. x-plain leukemia. 2010 April 02. Medline plus. .National Institutes of Health. Childhood Leukemia. 2010.Medline plus. .Current Medicine LLC. acute lymphoblastic leukemia blasts. 2005. Images MD. .Diseasedex. Acute myeloid leukemia. 2000. Micromedex. Maria AOUN 5/22/2012
  • 18. Bonus Maria AOUN 5/22/2012

Editor's Notes

  1. Leukemia accounts for about 33% of cancer cases in children aged 0-14.
  2. leukemia is an abnormal neoplastic proliferation of B cells. The cells accumulate mainly in the bone marrow and blood.
  3. Leukemia is diagnosed 10 times more often in adults than in children.
  4. Leukemia is diagnosed 10 times more often in adults than in children.