This study examined psychiatric comorbidities and treatment outcomes in 100 mentally ill prisoners referred to a tertiary psychiatric hospital in India. The most common primary diagnoses were substance use disorder (45%) and adjustment disorder (36%). 46% of prisoners had more than one psychiatric diagnosis, most commonly intellectual disabilities, personality disorders, and substance use disorders. 59% were treated with medication alone, 27% required inpatient admission, and outcomes were generally positive with patients responding well to treatment. The high rates of comorbidities suggest the need for integrated treatment approaches within prison psychiatric services.