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Network biology: A crash course on STRING and Cytoscape
1.
Network biology A crash
course on STRING and Cytoscape Lars Juhl Jensen
2.
STRING
3.
functional associations
4.
9.6 million genes
5.
string-db.org
6.
pathways
7.
protein complexes
8.
interaction screens
9.
gene coexpression
10.
genomic context
11.
many databases
12.
different formats
13.
different identifiers
14.
variable quality
15.
not comparable
16.
hard work
17.
(Ph.D. students)
18.
quality scores
19.
affinity purification
20.
von Mering et
al., Nucleic Acids Research, 2005
21.
score calibration
22.
von Mering et
al., Nucleic Acids Research, 2005
23.
implicit weighting by
quality
24.
common scale
25.
missing most of
the data
26.
>10 km
27.
too much to
read
28.
text mining
29.
comprehensive lexicon
30.
cyclin dependent kinase
1
31.
CDC2
32.
spaces and hyphens
33.
cyclin dependent kinase
1
34.
cyclin-dependent kinase 1
35.
prefixes and suffixes
36.
CDC2
37.
hCdc2
38.
“black list”
39.
SDS
40.
co-mentioning
41.
Cytoscape
42.
visualization
43.
analysis
44.
large networks
45.
not a database
46.
STRING App
47.
48.
49.
50.
51.
Acknowledgments Damian Szklarczyk John "Scooter"
Morris Helen Cook Michael Kuhn Stefan Wyder Milan Simonovic Alberto Santos Nadezhda Doncheva Alexander Roth Peer Bork Christian von Mering
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