This PowerPoint helps students to consider the concept of infinity.
Seminar on histamine
1. SEMINAR ON HISTAMINE
Under the guidance of Presented by
Prof .Mrs .Santhrani Thakur Deepika Darnasi ,
M.Pharm ,Ph.D l/ ll M. pharmacy,
Dept. of pharmacology
2. CONTENTS
• INTRODUCTION
• TYPES OF AUTOCOIDS
• LOCATION
• SYNTHESIS
• METABOLISM
• HISTAMINIC RECEPTORS
• PATHOLOGICAL AND PHYSIOLOGICAL ROLE
• PHARMACOLOGICAL ACTIONS
• THERAPEUTIC USES
3. INTRODUCTION
HISTAMINE:
Amine autocoid.
Autocoid (Greek word)
autos - self
akos - remedy/self healing substances
Secreted from special cells (endothelial cells or
tissues) & transported through the circulatory
system to act either locally (at the site of
synthesis or release) or on distant target tissues.
11. PHARMACOLOGICAL ACTIONS OF RECEPTORS
• H1 RECEPTORS
Contraction of smooth
muscles
Vasodilation of blood
vessels
Increase in capillary
permeability
• H3 RECEPTORS
Vasodilation of blood vessels
Decreases
neurotransmitter release
• H2 RECEPTORS
Increases gastric secretion
from gastric glands
Vasodilation of blood vessels
Relaxation of uterine smooth
muscles
Positive inotropic and
chronotropic effects on heart
H4 RECEPTORS
Causes chemotaxis of WBC
12. PATHOPHYSIOLOGICAL ROLE
PATHOLOGICAL ROLE
• In Hypersensitivity reactions
• In Inflammation
PHYSIOLOGICAL ROLE
• Gastric secretion
• Neuronal Transmission
• Tissue growth and repair
22. TISSUE GROWTH AND REPAIR
• Histamine-tissue amine,as tissues contain high
concentrations of histamine ,plays role in
growth and regeneration of tissues.
• Treats or prevents breast cancer.
• Blood merges with cholesterol and forms DDA
(Dendrogenin A) A compound with anti-tumour
properties
24. On heart:
H2-Positive chronotropic and inotropic effect.
H1-decrease AV conduction
On smooth muscles:
H1-stimulant effect on smooth muscles.
contraction of smooth muscles causing
bronchoconstriction and increased motility of
intestinal mucosa.
• On gastric glands:H2
• On CNS
• On ganglionic cells
25. THERAPEUTIC USES
• Diagnostic purposes.
positive control injection in skin hyper
reactivity testing.
Test acid secreting capacity of stomach.
Clinical diagnosis of pheochromocytoma.
26. REFERENCES
• ESSENTIALS OF MEDICAL PHARMACOLOGY,
6th Edition ,K D Tripathi.
• THE PHARMACOLOGICAL BASIS OF
THERAPEUTICS, Goodman and Gilman’s,
12th Edition.
• RANG AND DALE ,www.wikipedia.org