Thomas Gwatkin was born in 1741 in Herefordshire, Great Britain. He worked as a clergyman, tutor, and professor of mathematics and natural philosophy at the College of William and Mary. His parents and siblings are unknown, and he was not married while living in Williamsburg. He had a friendship with a man named John Nettles. Research shows that Thomas Gwatkin was a loyalist to Great Britain during the Revolutionary War period.