2. The key overall conceptual question in
front of the cardiothoracic surgical
community is:
Can we repair virtually every pure
BAV AI presentation as we
presently perform in the mitral
valve repair arena?
3.
4. BAV - Pathogenesis
Genetics
• Autosomal dominant, variable penetrance
• 9% prevalence in first-degree relatives
• 24% if >1 person affected
• Causal genes largely unknown
• NOTCH1 (9q34.3)