Anti Hemostatic Drugs

1. ANTI - HEMOSTATIC DRUGS

2. • ANTI THROMBOTIC
• THROMBOLYTIC DRUGS
• ANTI COAGULANTS

3. ANTI THROMBOTIC
• Anti platelet drug
• Aspirin-Low dose (80-160 mg)
•
• Ticlopidine
• Clopidogrel
• Mab –
• Dipyridamole
• Pentoxiphylline

4. Dipyridamole
(-)
Platelet activation

6. Pentoxiphylline
• Xanthine analogue
• Increases deformability of RBCs thus increases
microcirculation, reduce fibrinogen levels, inhibit
pl. aggregation.
• Uses- CVAs esp.TIA(transient ischemic attacks)
,
Ischemic ulcers of legs

7. Anti fibrinolytic
• Streptokinase
•
• Staphylokinase
• Alteplase=t-PA
• Reteplase =U-PA
• Tenecteplase

8. ANTICOAGULANTS
ENDOGENOUS EXOGENOUS

9. ANTICOAGULANTS
ENDOGENOUS
1. HEPARIN
2. ANTOTHROMBIN III
3. PROTEIN C
4. α2 MACROGLOBULIN
EXOGENOUS
1. HEPARIN
2. VIT K ANTAGONISTS
3. Ca SEQUESTERS
4. DEFIBRINATION
SUBSTANCES
5. COLD
6. HIRUDIN

10. ANTICOAGULANTS
• FOR BLOOD
COLLECTION
• FOR TREATMENT

11. ANTICOAGULANTS
• FOR BLOOD
COLLECTION
1. HEPARIN
2. Ca SEQUESTERS
3. COLD
• FOR TREATMENT

12. • HEPARIN

13. CALCIUM SEQUESTERS
• MOA
• OXALATES
• CITRATE
• TRISODIUM CITRATE
• EDTA
• SODIUM FLUORIDE
• HEPARIN

14. OXALATES
• Acts by insoluble salts with calcium in blood
to ppt Ca
• Ammonium :Potassium oxalate =2:3
• 2mg/dl
• Uses
• PCV
• ESR

15. CITRATE
• Acts by deionisation of calcium in blood
• Blood banks
• ACD
• CPD
• CPD-A
• 0.4 ml Na citrate in 1.6mlof blood

16. TRISODIUM CITRATE
• 3.8%

17. EDTA
• Sequester or chelating effect on calcium
• 1mg/dl
• ESR
• PT
• Uses- routine blood tests
Three types of EDTA salt – sodium
potassium
lithium
Dipotassium salt more soluble than Disodium salt, hence preferred

18. SODIUM FLUORIDE
• deionisation of calcium in blood
FIBRINOGEN
PT
PTT
ESR(by westergren method)
USES

19. COLD
• 5-10 0C

20. ANTICOAGULANTS FOR TREATMENT

22. ORAL
VIT K ANTAGONISTS
PROTEIN C

23. VITAMIN K ANTAGONISTS
• COUMARIN DERIVATIVES- DICOUMAROL
• WARFARIN
• PHENINDIONE

24. VITAMIN K
• SOURCES:
Causes of deficiency
• Obstructive jaundice
• New born babies
• c/c diarrhoea
• Side effect of antibiotic

26. VITAMIN K
• II
• VII
• IX
• X
• PROTEIN C
• PROTEIN S

27. HEPARIN

28. PARENTERAL- I V OR S/C

30. • COLD-5-10 0C
• HIRUDIN –leech-anti thrombin

31. • DEFIBRINATION SUBSTANCES
• Malaysian pit viper venom

32. Hemostatic drugs
• INHIBIT FIBRINOLYTIC SYSTEM
• COAGULATION SYSTEM
• CAPILLARY INTEGRITY
• VASOCONSTRICTORS
• WOUND SEALING AGENTS

33. INHIBIT FIBRINOLYTIC SYSTEM
• Eaca
• Transexemic acid
• aprotinin

35. COAGULATION SYSTEM
• vit k
• Botropase

36. CAPILLARY INTEGRITY
• Ethamsylate adrenochrome
• Vitamin c

37. VASOCONSTRICTORS
• Somatostatin
• adrenaline

38. WOUND SEALING AGENTS
• feracrylum