E. coli takes up plasmid DNA by which of the following methods? please choose correct answer thank you! Coli takes up plasmid DNA by which of the following methods? Select one: Transduction Transformation Conjugation Transfection Solution Answer - b . Transformation the process by which E.coli takes up foreign DNA is called transformation. Transfection is the process of taking foreign DNA by animal cells and conjugation and transfer are the process of reproduction in bacteria..