The document reviews the scientific validation of various parasurgical procedures described in Ayurveda such as Ksharakarma, Ksharasutra, Agnikarma, Raktamokshana, Siravyadha, Prachana, Shringa and Alabu. It discusses the actions of these procedures on specific diseases from a modern scientific perspective including theories like chemical cauterization, antimicrobial effects, counter irritation, and their effects on tissues, nerves and circulation. Key constituents in therapies like leech saliva and their anti-coagulant, thrombolytic, anti-inflammatory and vasodilatory actions are also summarized.
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Raktamokshana therapy is the blood cleansing &
purification therapy. It is the prime process of blood
detoxification. It is one among the shodhana karma
according to Acharya Sushruta & Charaka. Skin
diseases, Granthi, Shopha, Raktajanya diseases do not
occur in those persons who are subjected to proper
bloodletting time to time7
.
The specific indications of Jalaukacharana are Pitta
dushta raktaja rogas, Gulma, Arsha, Vidradhi,
Kushta, Vatarakta, Galarogas, Netrarogas, Visha and
Visarpa8
.
The specific indications of Siravyadha are Vidradhi
except tridoshaja, Arbuda, Granthi, Stanarogas, and
Dantapupputa etc Kshudrarogas are indicated.
Vagbhata added those conditions arise due to Pitta &
Kapha, diseases which do not respond to Sheeta-
Ushna, Snighda- Rooksha treatment should be
understood as being born of Dushta Rakta &
Raktamokshana should be performed9
.
Prachana is indicated in Pindita Rakta, Twak Rogas,
Indralupta, Kshudrarogas, and Utsedayukta Vrana.
Shringa is indicated in Vata dushta raktaja rogas,
while Alabu is indicated in Kapha dushta raktaja
rogas10, 11
.
SCIENTIFIC VALIDATION OF
PARASURGICAL PROCEDURES
1. Action of Kshara in Specific Diseases:
Haemorrhoids:
Causes Coagulation of proteins in Haemorrhoidal
plexus (Chemical Cauterization of Pile masses)
Disintegration of Haemoglobin into Haem and
globin Blackish brownish discharge
Necrosis of Tissues Sloughing in 3-7 days
Fibrosis of Plexus & Scar Tissue Formation
Adhesions of Mucosal, Sub mucosal coats
Prevention of further dilatation of veins &
Prolapse of regional Mucosa of anus.
Permanent radical obliteration of Hemorrhoids &
wound healing within 21 days.
Rectal Prolapse:
Induces aseptic fibrosis of the rectal mucosa and
adheres it properly
During healing it causes cicatrization, narrowing
of lumen and strengthens the anorectal ring.
Fistula-in-Ano:
In Low fistulas, after fistulotomy, helpful for quick
healing by debridement of fibrous tissue and avoids
recurrence.
Dushtavrana:
Best Substitue for Surgical debridement of Ulcer.
It acts only on the deranged, unhealthy growth &
hypertrophied tissues.
Promotes fast epithelization, increase collagen
deposition, reduced exudates and reduced edema
and promotes granulation tissue formation.
Tonsilitis:
Minute burns Coagulation of muco-
lymphoid tissues Reduces the intra-cellular space
& aggregates the lymphoid tissues Stimulates
fibrosis of tonsillar tissue reduces size of the
tonsils.
2. Action of Ksharasutra12,13,14,15,16
:
Fistula In Ano & Pilonidal Sinus:
Helps in Cutting, Curetting, Draining and Healing
of the fistulous track.
Caustic action - Destroys and removes unhealthy
tissues & Promotes healing of the fistulous track.
Controls infection by the microbicidal action.
Facilitate the drainage of Pus in fistulous track
and helps in healing.
Theories:
Theory of Chemical Cauterization.
Theory of Antimicrobial Effect.
Mere Mechanical cut & Open theory.
Novel technique of local drug delivery.
Action of Ksharasutra:
Days Action of Ksharasutra
1
Local irritation and discomfort in the
anal region.
2-4
Inflammation (local redness, burning
sensation).
4
Necrosis: Kshara comes in contact with
fistulous tract the stage of micro necrosis
begins.
5-6
Shedding of unhealthy granulation tissue
due to necrosis (cutting of fistulous
tract), fibroblastic proliferation.
7
The Haridra coating of new Ksharasutra
comes in contact with the fistulous tract
which completes the healing.
Low recurrence: The Ksharasutra allows invisible
minor ramifications to drain in to the major tract by
healing themselves totally before the major tract is
cutoff.
Hemorrhoids
Chemical Cauterization & Mechanical
Strangulation of the blood vessels.
Local gangrene of the pile mass
Ischemic necrosis and debridement of unhealthy
tissue.
Sloughing of mass & Healing of wound.
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3. Agnikarma
Possible Scientific Explanations:
1. Gate control therapy17
: Pain sensations are transferred by two types of fibers. “A” fibers (stimulated by
heat, cold and touch) and “C” fibers (stimulated by pain). Here the gate mechanism is blocked by stimuli
from A fiber, so the pain will not be felt.
2. According to scientist Dr. Ven Hanff18
: The place where heat burns the local tissue metabolism is
improved and thus it leads to increased demand of oxygen and nutrient of the tissue. This causes enhanced
delivery of nutrients and more efficient removal of waste products, hence speeding up the natural process of
repair.
3. Effect of heating on nerves19
: Heat appears to produce definite sedative effects. The effect of heat on
conduction has still to be thoroughly investigated but a physiological explanation has been offered by Sidney
Licht (1965), there is evidence that any sensory excitation reaching the brain simultaneously with a pain
excitation results in the pain impulse being more or less attenuated. Pain receptors of skin and motor end
plate stimulated at 450
C. Pathway for pain and thermal signals run parallel and ends into same area but only
stronger one can felt. Therefore complete exclusion of pain impulse by heat occurs.
4. Counter irritation theory20
: A counter irritant stimulates sensory nerve endings and relieves pain.
5. Effect on muscle tissue21
: Heat induces muscle relaxation.
6. TENS effect22
: Trans-electric nerve stimulation relieves pain by burning superficial nerve endings.
4. Rakta Mokshana
Siravyadha23
:
It is predominantly indicated in Pitta, Rakta & Kaphaja vyadhis or when pitta or kapha is in anubhandha to
vata dosha.
Helps to remove the Avarana of Pitta & Kapha dosha giving way for Anuloma Gati of Vititated vata.
Modern View24
:
Stimulation to large sensory fibers from peripheral tactile receptors depresses the transmission of pain
signals either from the same area of the body or even from many segments. This results in local inhibition.
It reduces intravascular pressure & volume which will reduces pain and swelling.
It reduces breakdown of RBC in turn reduces pigmentation & Itching.
Jalaukavacharana
The main constituents of the saliva of jalauka and their actions are as follows25
.
Constituents Mode of action
Hirudin
Most powerful Anti-coagulant, works as Diuretic & Antibiotic. (Other Anti-
coagulants: Hementin, Hementerin, Annastatin)
Bdellin Protease inhibitor like trypsin chymotrypsin or plasmin
Eglin Digestive protease
Apyrase &
Destabilase
Powerful platelet Anti-aggregate factor
Hyaluronidase Enzyme which breaks hyaluronic acid responsible for connective tissue bonding.
Anti- Elastase Degrade cutaneous elastastin at the level of Skin
Piavit Leech prostanoids and has protective antithrombotic effects
Haementin &
Orgelase
Have Hyperaemistic effect
Lipase, Estarase Lipolytic substance
Varicose Veins:
Anticoagulant effect: Hirudin by binding to thrombin. Also helps in reducing blood thickness and promotes
optimum blood flow. Calin by binding to collagen
Clot Dissolving effect : Detsabilize Breakup of Fibrin & Thrombolytic effect
Anti-Inflammatory Effect : Bdellins & Eglins Inhibits trypsin & Plasmin
Bacteriostatic & Anaesthetic effect:
Anesthetic like Substances Relieve pain
Bacteria inhibiting substances Inhibits growth of Bacteria
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Peripheral Vascular Diseases:
Constituents Mode of action
Hirudin Reduces factor VII -> Easy blood flow
Apyrase (Platelet
anti aggregate factor)
Thrombus Destruction
Eglin Acts as Anti-Oxidant by Reducing inflammation
Esterase Prevents Hypercoagulation & Reduce fat flow
Bdellin
Digests foreign protein matrix & also digests undue intimal wall of the blood
vessel
Hyalurodinase Diffuses the blood for free flow and excrets antibiotication
Histaminase Produces Vasodilatation action & Promotes regeneration
Dushtavrana:
Hirudin improves Microcirculation
Hyalurinidase Facilitates penetration & diffusion of pharmacologically active substances into the tissues
Trypsin, Plasmin Reduces pain during bite
Histamine Increase blood flow
Acetylcholine Vasodilator, Removing abnormal cells, reducing the bacterial load & formation of healthy
granulation tissues.
All together Microcirculation within the wound Bio-debridement prolonged oozing Healthy
granulation tissue formation.
Thrombosed Hemorrhoids:
Hirudin & Hyaluronidase capillary tissue exchanging Improves blood circulation
Thrombolytic action Dissolution of the organized blood clots
Reduces swelling, Reduces pain.
Plastic & Reconstructive Surgery:
Venous occlusion Thrombus Formation Flap necrosis
To relieve venous congestion leeches are used.
Alleviates tissue capillary pressure & local anticoagulation through
Active suction
Secretion of Vasoactive substance(Hirudin)
Passive oozing from bite wound
Better acceptance of flap: improving micro-circulation.
Reduced the rate of resection
Leech Therapy in Modern Science:
Anti-Inflammatory Action
Anti-Metastatic action
Anti-Hyperglycemic action
Anticoagulatory effect
Leech therapy in Dentistry
Leech therapy in Eye & ENT disorders
Leech therapy in Reconstructive surgeries
Shringa & Alabu:
Negative Pressure Stimulates circulation Vasodilatation Increasing blood supply Increasing the
metabolism faster elimination of waste substances.
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Cupping Therapy26
:
Prachana:
Prachana stimulates the accumulation of mast cells at the site & helps in improvement of circulation.
Prachana damages the superficial layers of skin and thus helps in rapid penetration of drugs.
DISCUSSION:
Acharyas have elaborately explained indication, mode
of action of these parasurgical procedures in their
treatises. But knowledge is only limited to Ayurveda
fraternity. For wider acceptance and to explain their
efficacy to modern world needs Scientific Validation.
In this regard a thorough research by incorporating
advanced techniques along with principles of
Ayurveda is of paramount necessity. Research based
standardization of the procedure helps in global
acceptance of Parasurgical procedures
CONCLUSION:
Parasurgical procedures are unique and one of the
greatest contributions of Ayurveda to the Surgical
Field. They come into play where Surgery faces
limitations. Scientific Validation of Parasurgical
procedures is necessary for the global acceptance of
our ancient science.
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