This document discusses the role of startups in the healthcare ecosystem. It notes that the healthcare ecosystem is complex and that startups have less to lose and are more risk-tolerant than powerful, risk-averse healthcare players. It provides examples of how mobile technologies like smartphones and apps have changed ecosystems. It also outlines the key players in a healthcare technology ecosystem, including people, teaching/training programs, projects, resources, and partnerships. Finally, it discusses solutions like connecting curriculum and Hubvantage, a mentorship program to help healthcare startups by providing faster understanding, connections, and introductions to advisors and investors.