2) Calcium channels serve as passage to allow the transport of calcium ions in the membranes. If these channels are blocked, then the transmission of neurotransmitters will be inhibited and acetylcholine receptors at the neuromuscular junction would not function. Many toxins neurotoxins like botulinum, tetanus, latrotoxin and snake venom block these acetylcholine receptors and cause the hardening of muscles. 1) The anesthetic agents when inhaled, open up the chlorine channels in the membrane. This causes the flow of chlorine ions into the neurons. This causes a shift towards the negative potential and difficulty for the neuron to reach back to the action potential. Hence, the person goes in the sleeping phase. Solution 2) Calcium channels serve as passage to allow the transport of calcium ions in the membranes. If these channels are blocked, then the transmission of neurotransmitters will be inhibited and acetylcholine receptors at the neuromuscular junction would not function. Many toxins neurotoxins like botulinum, tetanus, latrotoxin and snake venom block these acetylcholine receptors and cause the hardening of muscles. 1) The anesthetic agents when inhaled, open up the chlorine channels in the membrane. This causes the flow of chlorine ions into the neurons. This causes a shift towards the negative potential and difficulty for the neuron to reach back to the action potential. Hence, the person goes in the sleeping phase..