What type of mutation that impacts splicing is a significant contrib.pdf

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What type of mutation that impacts splicing is a significant contributor to human disease? Solution Disruptions in splicing are major contibutor of human diseases.Most genes in higher eukaryotes are composed of introns (non coding segments) and exons (coding segments). The majority of human intron removals ae catalyzed by a large and dynamic ribonucleoprotein (RNP) complex called the spliceosome.This process involves two sequential transesterification reactions which ligate the exons and release the intron as a lariat. Alternate splicing which allows for the productioin of many proteins from a single genomic locous.This greatly augments the repertorie of the protein.This greatly augments the repertoire of proteins that can be produced by a given gene and plays an important role in evolution,development and disease..

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Write an equation for the height of the point P above the ground as a function of t, time in seconds. h(t) = Hint: Start by thinking: What is the height of the point P above the center? How is the center changing? Solution height of center at ant time = R + 7(sinA)t = 2 + 7(100/700)t = (2 + t) cm now height of P wrt center = Rcos(x/2) where x = 7t height of P = 2+ t + Rcos(7t/2) = 2 + t + 2cos(7t/2) 7t/2 is value in radian. oon putting t in second for t= 0,(starting point) height = 2 + 2cos0 = 4 cm at the end, at = 100 cm, h = 2 + 100 + 2cos(350) = 101.433 cm.

Write an equation for the height of the point P above the ground as .pdf

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Wild-type (WT) mice are irradiated, destroying all of their bone marrow cells including CD34+ hematopoietic stem cells (HSC). CD34+ HSC is isolated from (1) an untreated wild-type syngeneic control mouse, and (2) various immune gene mutant (-/- null) donor mice. The CD34+ HSC from the different mouse genotypes is injected into the wild-type irradiated recipient mice. Predict the reconstitution of the hematopoietic system in each of the recipient mice (+ or -). Solution Answer - Hematopoietic cells reconstituted in recipient CD34+HSC Doner GenotypeErythrocytes macrophages T cells B cells Wild Type mouse + + + + CD19(-/-)mouse + + + - Rag1/2(-/-)mouse + + - - erythropoietin EPO(-/-) - + + + AIRE(-/-)mouse + + + + explaination -Wild type mouse has normal CD34+HSC which is responsible to diffentiate into all type of immune cells in bone marrow. Whwn this CD34+HSC from wild type mouse injected into recipient mouse its bone marrow produce all type of immune cells. CD19 is a B cell lymphocyte antigen It is a protein which is coded by CD19 gene. it is found on the surface of B cells and helps in its proliferation and differenciation.CD34+HSC from doner who lack CD19 gene when injected into recipient mouse,It will be unable to produce B cell. Rag 1/2 also known as recombination activating gene codes a protein which paly an important role in recombination of the gene of immunoglobuline and T cell receptor marker.two gene products of recombination activating gene are Rag 1 and Rag 2 protein.These two rag protein are essential to the generation of mature Bcells and Tcells. .CD34+Hsc from doner who lack the gene codes gor Rag1/2 protein when injected to the recipient mouse, recipient mousewill be unable to produce mature B and T cells. Erythropoietin EPO is a protein harmone secreated by kidney in responce to less oxygen/Heamoglobine in blood.erythropoietin stimulates bone marrow to produce more Red blood cells (erythrocytes) which contain Heamoglobine ( an Oxygen carrier) and supply required amount of oxygen to the body by mean of blood flow through the body. when CD34+HSC from doner lack the gene codes for Erythropoietin injected into recipient mouse,it bone marrow will be unable to produce erythrocytes. AIRE is an auto immune regulator protein encoded by AIRE gene.It controles a mechanism that prevent T cells (an important cell for immune response) from attacking the self body antigen.T cells recognizes antigen which are expresed on the surface of antigen presenting cell by T cell receptors present on T cells and produce Immune responce against that antigen. In autoimmune diseases T cell Recognize self antigen and produce immune response against self antigen which leads to sever problem in self body.AIRE protein play an important role to controle these kind of autoimmune disorders by the removel of T cell through apoptosis while T cells are still in thymus. When CD34+HSC from doner WHICh lake the gene for AIRE protein injected into recipient mouse.Reci.

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Which of the following is considered to be a distributed denial of service attack because it comes from numerous sources?a.Smurf Solution The Distributed denial of service (DDOS) is an attack where the attacker repeatedly pings the server from different computers/servers to restrict the server from handling the requests of the legitimate users. This way all the requests of the authorized users will get be declined. The SYN flood attack and the death ping send multiple requests to the server from a single source and the sequence prediction attack is used to analyze the traffic to identify the data packets. The smurf attack uses a broadcast network to send multiple requests to the server from different sources. Hence, the correct options is a. Smurf..

Which of the following is considered to be a distributed denial of s.pdf

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Which of the folllowing statements about the solubility of 1- propan.pdf

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Two four-sided dice are rolled. One die has the letters A through D..pdf

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I wanna add the shape creator like rectangular , square , circle etc.pdf

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