5. What is the role of the SRY gene in determining sex? Solution ANS: SRY (Sex Determining Region of Y chromosome) Gene: In the early stage of embryonic development, immature gonads of male and female are indistinguishable. Male: During the 7th week of embryonic development, SRY gene present on the Y chromosome is activated. So due to these later gonads develops into testes. Female: In females SRY gene is absent, so gonads later develops into ovaries by default. The Y chromosome in humans contains SRY gene. This gene can capable to produce TDF (testis determining factor). On Y chromosome approximately 150 genes are present. SRY region only determines male characteristics. In mice spontaneous deletion or insertion of SRY gene can results, in mice with XX have testes and XY mice present with ovaries..