1. אלרגיה לחלבון חלב פרה או אי סבילות ללקטוז ? יונה אמיתי ושמאל גרוס כנס : מתעדכנים בתזונת ילדים 29 ביוני 2009, ירושלים
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19. שיעורי ההנקה בישראל – סקר לאומי ב -2000 דורית ניצן - קלוסקי , משרד הבריאות סך הכול n=1,030 ערביות n=412 יהודיות n=618 גיל 82% 89% 79% שבוע 80% 87% 76% שבועיים 73% 86% 67% חודש 68% 77% 61% חודשיים 57% 68% 51% 3 חודשים 50% 60% 45% 4 חודשים 38% 50% 32% 6 חודשים 23% 36% 17% 9 חודשים 14% 21% 10% שנה
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21. Most frequent symptoms of Cow Milk Protein Allergy , Vandeplas et al., Arch Dis Child 2007 GI Frequent regurgitation Vomiting Diarrhoea Constipation (with/without perianal rash) Blood in stool Iron deficiency anaemia Skin Atopic dermatitis Swelling of lips or eye lids (angio-oedema) Urticaria unrelated to acute infections drug intake, other causes Respiratory Runny nose (otitis media) (not infectious) Chronic cough Wheezing General Persistent distress or colic (wailing/irritable 3 h/ day) at least 3 days/week over a period of >3 weeks
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27. Cow’s Milk Allergy: A Complex Disorder Crittenden, Bennett, J Am Coll Nutr, 2005 אי סבילות ללקטוז IgE mediated CMPA (immediate) Non IgE mediated CMPA שכיחות שכיח תינוקות : 2-6%, כמחצית מכל סוג מבוגרים : 0.1-0.5% גיל בכל גיל תינוקות תינוקות ומבוגרים מנגנון מטבולי חיסוני : IgE חיסוני : cell mediated סימפטומים GI GI עור נשימתיים GI נשימתיים זמן הופעה לאחר אכילה 0.5-2 שעות < שעה מס . שעות או ימים אבחנה העמסת לקטוז BREATH TEST PH צואה ביופסיה מעי SKIN PRICK TEST RADIO ALLERGO SORBENT TEST (RAST) מסובכת תבחין כפול סמויות
29. Percentage of children achieving the recommended daily adequate intake for calcium Greer, Krebs, Committee on Nutrition . Optimizing Bone Health and Calcium Intakes of Infants, Children, & Adolescents PEDIATRICS 2006
36. Soy-Based Infant Formula: Concerns and Recommendations Testimony presented to the US Food and Drug Administration Dietary Supplements, Additives and Ingredients, Food Biotechnology, Contaminants and Natural Toxicants, and Infant Formula Subcommittees December 11, 2003 Sally Fallon, President The Weston A. Price Foundation
37. Soy-Based Infant Formula About 25% of formula-fed babies in the US receive soy-based infant formula
38. I. Soy Protein Isolate Soy Protein Isolate (SPI) is the major ingredient in soy-based infant formula SPI is produced using many chemicals and at high temperatures and pressures, causing a reduction in protein quality Processing reduces many anti-nutrients naturally occurring in soy (phytic acid, protease inhibitors, lectins, etc.) In rats, feeding SPI caused increased requirements for vitamins E,K,D, B12, created deficiency symptoms of Ca, Mg, Mn, molybdenum, Cu, Fe and zinc. (Joseph, J Rackis, “Biological and physiological Factors in Soybeans,” Journal of the American Oil Chemists’ Society , January 1974, 51:161A-170A) SPI does not have Generally Recognized as Safe (GRAS) status
39. II. Lack of Cholesterol Dietary cholesterol is vital for the optimal development of the infant. Mother’s milk is very high in cholesterol and contains an enzyme that ensures complete assimilation of the cholesterol. Unlike milk- and meat-based infant formula, soy-based formula contains no cholesterol.
40. III. Phytoestrogens Associated with endocrine disruption , depression of immune system and thyroid Reproductive; infertility Thyroid and liver disease due to dietary intake of phytoestrogens, observed in animals (mice, rats, cheetah, sheep, pigs, marmoset monkeys) Children on soy-based formula have levels of estrogens 13,000-22,000 times higher than children on milk-based formula ( Am J Clin Nutr 1998 Dec;68(6 Suppl):1453S-1461S)
41. PHYTOESTROGENS IN DIETS OF INFANTS & ADULTS Average Isoflavones Isoflavone per Kg Intake Body Weight* Japan (1996 survey) 10 mg 0.17 mg Japan (1998 survey) 25 mg 0.42 mg Japan (2000 survey) 28 mg 0.47 mg In Japanese women receiving adequate iodine, causing thyroid suppression 38 mg 0.60 mg In American women, causing hormonal changes after 1 month 45 mg 0.75 mg FDA recommended amount for adults 25 mg 0.42 mg In children receiving soy formula 38 mg 6.25 mg * Assumed 60 kg for adults, 6 kg for infants
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Editor's Notes
Twenty-five percent of bottle-fed infants in the US receive soy-based formula. The key ingredient of soy infant formula is soy protein isolate, which does not have GRAS status.
This chart illustrates why soy infant formula is so dangerous. Three surveys of Japanese diets indicate a range of 10-28 mg isoflavones per day, which on a body-weight basis is 0.17 – 0.47 mg per kg of bodyweight per day. When higher amounts are given, problems occur. For example, 0.60 mg per kg of bodyweight caused thyroid suppression in Japanese women receiving adequate iodine; and 0.75 mg per kg bodyweight caused hormonal changes in American women after just one month. In fact, in the latter study, it took 3 months after discontinuing the isoflavones for hormones to normalize. The FDA recommended amount is within the range found in Japanese diets, or about 0.42 mg per kg bodyweight per day. Infants on soy formula receive about 38 mg isoflavones per day, which works out to 6.25 mg per kg of bodyweight, or about ten times more than the amounts that caused problems in adults. Would any parent, knowing this, ever give soy infant formula to their baby?