1. Scientific Supervisors : Prof. Dr.B.I.Polyakov Dr.M.Y. Fedyanin Presented by: Dr.Ye Hlaing Bwar Significance of Prognostic Factors in Epithelial Ovarian Cancer M.V.LOMONOSOV MOSCOW STATE UNIVERSITY Faculty of Basic Medicine

2. Ovarian cancer is the fifth leading cause of death from cancer in women. Leading cause of death from gynecological cancer in United State .

4. Prognostic factor - any measurement available at the time of surgery or diagnosis that correlates with disease-free or overall survival and, as a result, is able to correlate with the natural history of the disease. (>90%) Epithelial Ovarian Cancer

5. Prognostic Factors in Epithelial Ovarian Cancer Prognostic Factors - Age - Histology - Grade - Stage(FIGO) - ECOG performance status - CA125 - Ascites - Residual disease - Ploidy - Type of chemotherapy - Interval debulking

7. Aim of Study To indentify the statistical significance prognostic factors in epithelial ovarian cancer treated with surgery and primary systemic chemotherapy.

10. Patients and Methods Statistical Analysis - MedCalc software (version 9.6) - x 2 test to compare distribution of baseline characteristics - Fisher’s exact test where appropriate - Kaplan-Meier method for survivals, log-rank test for comparison & Cox proportional hazard regression models for multivariate analysis Follow-up - every 3 months for 1 st two years, every 6 months for next 3 yrs & annually thereafter

11. Distribution of Patients Baseline Characteristics (n=55)

12. 5 year Overall Survival Rate (n=55)

13. Univariate Analysis of Prognostic Factors

14. Significance in Sub-group of prognostic factor

16. Thank You!