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eric c. larson | eclarson.com
interdisciplinary computer science and engineering
mobilizing mhealth
Assistant Professor Co...
databases
algorithms
arch
AI
OS
Comp
Sci
Wednesday, September 11, 13
mobile
databases
algorithms
arch
AI
OS
Comp
Sci
Wednesday, September 11, 13
mobile
databases
algorithms
arch
AI
OS
Comp
Sci
mhealth
Wednesday, September 11, 13
mobile
databases
algorithms
arch
AI
OS
Comp
Sci
mhealth
Wednesday, September 11, 13
what is mhealth?
Wednesday, September 11, 13
stress check
glucose buddy
fitness trainer
heart rate
zombie run
Wednesday, September 11, 13
Wednesday, September 11, 13
consider physician’s need
Wednesday, September 11, 13
Wednesday, September 11, 13
compliance?
cost?
doctor patient?
Wednesday, September 11, 13
compliance?
cost?
doctor patient?
Wednesday, September 11, 13
cost
Wednesday, September 11, 13
compliance
Wednesday, September 11, 13
compliance
Wednesday, September 11, 13
what can the mobile phone
already sense ubiquitously?
Wednesday, September 11, 13
Wednesday, September 11, 13
accelerometer
gyroscope
magnetometer /compass
dual camera / flash
1+ microphones
proximity sensor
capacitive sensor
gps
mot...
accelerometer
gyroscope
magnetometer /compass
dual camera / flash
1+ microphones
proximity sensor
capacitive sensor
gps
mot...
what can the mobile phone
sense with clinical utility?
Wednesday, September 11, 13
future
research
lung
function
jaundice
Wednesday, September 11, 13
future
research
lung
function
jaundice
Wednesday, September 11, 13
spirometer lung function??
Wednesday, September 11, 13
spirometer
device that measures
amount of air inhaled and
exhaled.
Wednesday, September 11, 13
lung function
asthma
COPD
cystic fibrosis
evaluates pulmonary
impairments
Wednesday, September 11, 13
using a spirometer
flow
volume
volume
time
Wednesday, September 11, 13
using a spirometer
flow
volume
volume
time
Wednesday, September 11, 13
using a spirometer
flow
volume
volume
time
Wednesday, September 11, 13
volume-time graph
volume
time
Wednesday, September 11, 13
volume-time graph
volume
time
Wednesday, September 11, 13
volume-time graph
volume
time
FEV1
FVC
FEV1: Forced Expiratory Volume in 1 second
FVC: Forced Vital Capacity
Wednesday, Se...
volume-time graph
volume
time1 sec.
FEV1
FVC
FEV1: Forced Expiratory Volume in 1 second
FVC: Forced Vital Capacity
Wednesd...
volume-time graph
volume
time1 sec.
FEV1
FVC
FEV1% = FEV1/FVC
FEV1: Forced Expiratory Volume in 1 second
FVC: Forced Vital...
FEV1: Forced Expiratory Volume in 1 second
FVC: Forced Vital Capacity
FEV1% = FEV1/FVC
Wednesday, September 11, 13
FEV1: Forced Expiratory Volume in 1 second
FVC: Forced Vital Capacity
FEV1% = FEV1/FVC
> 80% healthy
60 - 79% mild
40 - 59...
flow-volume graph
flow
volume
Wednesday, September 11, 13
flow-volume graph
flow
volume
Wednesday, September 11, 13
flow
volume
FEV1 FVC
1 sec.
PEF
PEF: Peak Expiratory Flow
FEV1: Forced Expiratory Volume in 1 second
FVC: Forced Vital Capa...
flow
volume
normal
flow-volume graph
Wednesday, September 11, 13
flow
volume
normal
obstructive
flow-volume graph
Wednesday, September 11, 13
obstructive diseases
resistance in air path leads to reduced air flow
Wednesday, September 11, 13
obstructive diseases
resistance in air path leads to reduced air flow
Wednesday, September 11, 13
restrictive diseases
lungs are unable to pump enough air and pressure
Wednesday, September 11, 13
restrictive diseases
lungs are unable to pump enough air and pressure
Wednesday, September 11, 13
flow-volume graph
Flow
Volume
normal
obstructive
Wednesday, September 11, 13
flow-volume graph
Flow
Volume
normal
restrictive
obstructive
Wednesday, September 11, 13
clinical spirometry
Wednesday, September 11, 13
home spirometry
Wednesday, September 11, 13
home spirometry
faster detection
rapid recovery
trending
Wednesday, September 11, 13
home spirometry
high cost barrier
patient compliance
less coaching
limited integration
challenges with
Wednesday, Septembe...
flow rate
volume
lung function
airflow
sensor
Wednesday, September 11, 13
flow rate
volume
lung function
airflow
sensor
sound
pressure
microphone
Wednesday, September 11, 13
flow rate
volume
lung function
airflow
sensor
sound
pressure
microphone processing
estimated
Wednesday, September 11, 13
SpiroSmart
availability
cost
portability
more effective coaching interface
integrated uploading
Wednesday, September 11, 13
Using SpiroSmart
Wednesday, September 11, 13
Using SpiroSmart
Wednesday, September 11, 13
Using SpiroSmart
]
Wednesday, September 11, 13
Using SpiroSmart
]
Wednesday, September 11, 13
Using SpiroSmart
]
Wednesday, September 11, 13
Using SpiroSmart
Wednesday, September 11, 13
study design
x 3
x 3
Wednesday, September 11, 13
study enrollment
Wednesday, September 11, 13
study enrollment
participants 52
18-75 years old, mostly healthy18-75 years old, mostly healthy
study a
Wednesday, Septemb...
study enrollment
participants 52
18-75 years old, mostly healthy18-75 years old, mostly healthy
study a
participants 10
12...
study enrollment
participants 52
18-75 years old, mostly healthy18-75 years old, mostly healthy
study a
participants 10
12...
audio
Wednesday, September 11, 13
audio
flow features
Wednesday, September 11, 13
audio
flow features
measures
regression
FEV1
FVC
PEF
Wednesday, September 11, 13
0 1 2 3 4
0
5
10
15
Flow(L/s)
Volume(L)
1
2
3
4
Volume(L)
0 1 2 3 4
0
5
10
15
Flow(L/s) Volume(L)
0 2 4 6 8 10
0
1
2
3
4
t...
0 1 2 3 4
0
5
10
15
Flow(L/s)
Volume(L)
1
2
3
4
Volume(L)
0 1 2 3 4
0
5
10
15
Flow(L/s) Volume(L)
0 2 4 6 8 10
0
1
2
3
4
t...
0 1 2 3 4 5 6 7
−1
−0.5
0
0.5
1
time(s)
amplitude
flow features
Wednesday, September 11, 13
0 1 2 3 4 5 6 7
−1
−0.5
0
0.5
1
time(s)
amplitude
flow features
vocal tractsource output
frequency(Hz)
1 2 3 4 5 6
0
500
10...
0 1 2 3 4 5 6 7
−1
−0.5
0
0.5
1
time(s)
amplitude
flow features
0 1 2 3 4 5 6 7
−1
−0.5
0
0.5
1
time(s)
amplitude
envelope ...
curve
regression
−1 0 1 2 3 4 5
0
0.1
0.2
0.3
0.4
time(s)
featurevalue
0 1 2 3 4 5
0
0.1
0.2
0.3
0.4
time(s)
featurevalue
...
−1 0 1 2 3 4 5
0
2
4
6
8
time(s)
flow(L/s)
curve
regression
−1 0 1 2 3 4 5
0
0.1
0.2
0.3
0.4
time(s)
featurevalue
0 1 2 3 ...
results
measures
regression
Wednesday, September 11, 13
results
measures
regression
Wednesday, September 11, 13
curve
regression
−2 0 2 4 6
0
5
10
15
volume(L)
flow(L/s)
−1 0 1 2 3 4
0
2
4
6
8
volume(L)
flow(L/s)
Wednesday, September ...
curve
regression
−2 0 2 4 6
0
5
10
15
volume(L)
flow(L/s)
−2 0 2 4 6
0
5
10
15
volume(L)
flow(L/s)
−1 0 1 2 3 4
0
2
4
6
8
...
curve
regression
−2 0 2 4 6
0
5
10
15
volume(L)
flow(L/s)
−2 0 2 4 6
0
5
10
15
volume(L)
flow(L/s)
−2 0 2 4 6
0
5
10
15
vo...
curve
regression
−2 0 2 4 6
0
5
10
15
volume(L)
flow(L/s)
−2 0 2 4 6
0
5
10
15
volume(L)
flow(L/s)
−2 0 2 4 6
0
5
10
15
vo...
can SpiroSmart curves be
used for diagnosis?
Wednesday, September 11, 13
survey
Wednesday, September 11, 13
• 10 subjects curves
survey
Wednesday, September 11, 13
• 5 pulmonologists
• 10 subjects curves
survey
Wednesday, September 11, 13
• 5 pulmonologists
• 10 subjects curves
• unaware if from SpiroSmart / spirometer
survey
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
results
normal
minimal obstructive
mild obstructive
moderate obstructive
severe obstructive
restrictive
inadequate
Wednesd...
results
normal
minimal obstructive
mild obstructive
moderate obstructive
severe obstructive
restrictive
inadequate
identic...
results
normal
minimal obstructive
mild obstructive
moderate obstructive
severe obstructive
restrictive
inadequate
one off...
results
normal
minimal obstructive
mild obstructive
moderate obstructive
severe obstructive
restrictive
inadequate
one off...
results
normal
minimal obstructive
mild obstructive
moderate obstructive
severe obstructive
restrictive
inadequate false p...
results
normal
minimal obstructive
mild obstructive
moderate obstructive
severe obstructive
restrictive
inadequate
false n...
results
normal
minimal obstructive
mild obstructive
moderate obstructive
severe obstructive
restrictive
inadequate
error
8...
results
normal
minimal obstructive
mild obstructive
moderate obstructive
severe obstructive
restrictive
inadequate
error
8...
appropriate for
screening and early diagnosis
Wednesday, September 11, 13
appropriate for
screening and early diagnosis
in the home? in the developing world?
Wednesday, September 11, 13
Wednesday, September 11, 13
in 10 years, COPD will surpass AIDS/HIV as cause of
death in developing nations
Wednesday, September 11, 13
in 10 years, COPD will surpass AIDS/HIV as cause of
death in developing nations
Wednesday, September 11, 13
future
research
lung
function
jaundice
Wednesday, September 11, 13
future
research
lung
function
jaundice
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
Wednesday, September 11, 13
neonatal jaundice in the US
kernicterus:
21
hazardous
jaundice: 1158
extreme jaundice:
2,317
severe jaundice: 35,000
photo...
Method Accuracy Disadvantages
TSB
Gold standard
(r=1.0)
Painful, costly,
inconvenient, delayed
TcB
Accurate
(r= 0.75 -0.93...
Wednesday, September 11, 13
bilicam
Wednesday, September 11, 13
Wednesday, September 11, 13
participants 40
0-4 days old, collected in nursery0-4 days old, collected in nursery
study a
Wednesday, September 11, 13
participants 40
0-4 days old, collected in nursery0-4 days old, collected in nursery
study a
Wednesday, September 11, 13
Color
Linearization
• Camera Settings
Adjustment
• Light Source Estimation
Image
Segmentation
• Quality Control for Distan...
051015
TcBvalues
0 5 10 15
bilicam values
Fitted values bilicam
bilirubinlevel
bilicam estimation
0
15
155 10
5
10
mg/dl
r...
Wednesday, September 11, 13
• near term: screening
Wednesday, September 11, 13
• near term: screening
• medium term: TSB study
Wednesday, September 11, 13
• near term: screening
• medium term: TSB study
• long term: developing world
Wednesday, September 11, 13
• near term: screening
• medium term: TSB study
• long term: developing world
“in many resource poor nations,
hyperbilirub...
future
research
lung
function
jaundice
Wednesday, September 11, 13
future
research
lung
function
jaundice
Wednesday, September 11, 13
oxygen volume, VO2
Wednesday, September 11, 13
blood pressure
Wednesday, September 11, 13
intra ocular pressure
Wednesday, September 11, 13
intra ocular pressure
Wednesday, September 11, 13
Wednesday, September 11, 13
activity detection
elder care
daily activity logs
congestive heart failure
health markers via phone
blood pressure
pulse o...
activity detection
elder care
daily activity logs
congestive heart failure
health markers via phone
blood pressure
pulse o...
take away
• CSE has a large role in the coming evolution of
mHealth, equal to doctors
• sensing and clinical utility
• dep...
eric c. larson | eclarson.com
interdisciplinary computer science and engineering
mobilizing mhealth
Assistant Professor Co...
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Mobilizing mHealth: interdisciplinary computer science and engineering

  1. 1. eric c. larson | eclarson.com interdisciplinary computer science and engineering mobilizing mhealth Assistant Professor Computer Science and Engineering Wednesday, September 11, 13
  2. 2. databases algorithms arch AI OS Comp Sci Wednesday, September 11, 13
  3. 3. mobile databases algorithms arch AI OS Comp Sci Wednesday, September 11, 13
  4. 4. mobile databases algorithms arch AI OS Comp Sci mhealth Wednesday, September 11, 13
  5. 5. mobile databases algorithms arch AI OS Comp Sci mhealth Wednesday, September 11, 13
  6. 6. what is mhealth? Wednesday, September 11, 13
  7. 7. stress check glucose buddy fitness trainer heart rate zombie run Wednesday, September 11, 13
  8. 8. Wednesday, September 11, 13
  9. 9. consider physician’s need Wednesday, September 11, 13
  10. 10. Wednesday, September 11, 13
  11. 11. compliance? cost? doctor patient? Wednesday, September 11, 13
  12. 12. compliance? cost? doctor patient? Wednesday, September 11, 13
  13. 13. cost Wednesday, September 11, 13
  14. 14. compliance Wednesday, September 11, 13
  15. 15. compliance Wednesday, September 11, 13
  16. 16. what can the mobile phone already sense ubiquitously? Wednesday, September 11, 13
  17. 17. Wednesday, September 11, 13
  18. 18. accelerometer gyroscope magnetometer /compass dual camera / flash 1+ microphones proximity sensor capacitive sensor gps motorized actuator Wednesday, September 11, 13
  19. 19. accelerometer gyroscope magnetometer /compass dual camera / flash 1+ microphones proximity sensor capacitive sensor gps motorized actuator compliance++; cost--; dr_pat *= 10; Wednesday, September 11, 13
  20. 20. what can the mobile phone sense with clinical utility? Wednesday, September 11, 13
  21. 21. future research lung function jaundice Wednesday, September 11, 13
  22. 22. future research lung function jaundice Wednesday, September 11, 13
  23. 23. spirometer lung function?? Wednesday, September 11, 13
  24. 24. spirometer device that measures amount of air inhaled and exhaled. Wednesday, September 11, 13
  25. 25. lung function asthma COPD cystic fibrosis evaluates pulmonary impairments Wednesday, September 11, 13
  26. 26. using a spirometer flow volume volume time Wednesday, September 11, 13
  27. 27. using a spirometer flow volume volume time Wednesday, September 11, 13
  28. 28. using a spirometer flow volume volume time Wednesday, September 11, 13
  29. 29. volume-time graph volume time Wednesday, September 11, 13
  30. 30. volume-time graph volume time Wednesday, September 11, 13
  31. 31. volume-time graph volume time FEV1 FVC FEV1: Forced Expiratory Volume in 1 second FVC: Forced Vital Capacity Wednesday, September 11, 13
  32. 32. volume-time graph volume time1 sec. FEV1 FVC FEV1: Forced Expiratory Volume in 1 second FVC: Forced Vital Capacity Wednesday, September 11, 13
  33. 33. volume-time graph volume time1 sec. FEV1 FVC FEV1% = FEV1/FVC FEV1: Forced Expiratory Volume in 1 second FVC: Forced Vital Capacity Wednesday, September 11, 13
  34. 34. FEV1: Forced Expiratory Volume in 1 second FVC: Forced Vital Capacity FEV1% = FEV1/FVC Wednesday, September 11, 13
  35. 35. FEV1: Forced Expiratory Volume in 1 second FVC: Forced Vital Capacity FEV1% = FEV1/FVC > 80% healthy 60 - 79% mild 40 - 59% moderate < 40% severe Wednesday, September 11, 13
  36. 36. flow-volume graph flow volume Wednesday, September 11, 13
  37. 37. flow-volume graph flow volume Wednesday, September 11, 13
  38. 38. flow volume FEV1 FVC 1 sec. PEF PEF: Peak Expiratory Flow FEV1: Forced Expiratory Volume in 1 second FVC: Forced Vital Capacity flow-volume graph Wednesday, September 11, 13
  39. 39. flow volume normal flow-volume graph Wednesday, September 11, 13
  40. 40. flow volume normal obstructive flow-volume graph Wednesday, September 11, 13
  41. 41. obstructive diseases resistance in air path leads to reduced air flow Wednesday, September 11, 13
  42. 42. obstructive diseases resistance in air path leads to reduced air flow Wednesday, September 11, 13
  43. 43. restrictive diseases lungs are unable to pump enough air and pressure Wednesday, September 11, 13
  44. 44. restrictive diseases lungs are unable to pump enough air and pressure Wednesday, September 11, 13
  45. 45. flow-volume graph Flow Volume normal obstructive Wednesday, September 11, 13
  46. 46. flow-volume graph Flow Volume normal restrictive obstructive Wednesday, September 11, 13
  47. 47. clinical spirometry Wednesday, September 11, 13
  48. 48. home spirometry Wednesday, September 11, 13
  49. 49. home spirometry faster detection rapid recovery trending Wednesday, September 11, 13
  50. 50. home spirometry high cost barrier patient compliance less coaching limited integration challenges with Wednesday, September 11, 13
  51. 51. flow rate volume lung function airflow sensor Wednesday, September 11, 13
  52. 52. flow rate volume lung function airflow sensor sound pressure microphone Wednesday, September 11, 13
  53. 53. flow rate volume lung function airflow sensor sound pressure microphone processing estimated Wednesday, September 11, 13
  54. 54. SpiroSmart availability cost portability more effective coaching interface integrated uploading Wednesday, September 11, 13
  55. 55. Using SpiroSmart Wednesday, September 11, 13
  56. 56. Using SpiroSmart Wednesday, September 11, 13
  57. 57. Using SpiroSmart ] Wednesday, September 11, 13
  58. 58. Using SpiroSmart ] Wednesday, September 11, 13
  59. 59. Using SpiroSmart ] Wednesday, September 11, 13
  60. 60. Using SpiroSmart Wednesday, September 11, 13
  61. 61. study design x 3 x 3 Wednesday, September 11, 13
  62. 62. study enrollment Wednesday, September 11, 13
  63. 63. study enrollment participants 52 18-75 years old, mostly healthy18-75 years old, mostly healthy study a Wednesday, September 11, 13
  64. 64. study enrollment participants 52 18-75 years old, mostly healthy18-75 years old, mostly healthy study a participants 10 12-17 years old, mixed healthy/abnormal12-17 years old, mixed healthy/abnormal study b Wednesday, September 11, 13
  65. 65. study enrollment participants 52 18-75 years old, mostly healthy18-75 years old, mostly healthy study a participants 10 12-17 years old, mixed healthy/abnormal12-17 years old, mixed healthy/abnormal study b participants 56 10-69 years old, mostly abnormal10-69 years old, mostly abnormal study c enrolledby pulmonologists Wednesday, September 11, 13
  66. 66. audio Wednesday, September 11, 13
  67. 67. audio flow features Wednesday, September 11, 13
  68. 68. audio flow features measures regression FEV1 FVC PEF Wednesday, September 11, 13
  69. 69. 0 1 2 3 4 0 5 10 15 Flow(L/s) Volume(L) 1 2 3 4 Volume(L) 0 1 2 3 4 0 5 10 15 Flow(L/s) Volume(L) 0 2 4 6 8 10 0 1 2 3 4 time(s) Volume(L) audio flow features measures regression curve regression FEV1 FVC PEF Wednesday, September 11, 13
  70. 70. 0 1 2 3 4 0 5 10 15 Flow(L/s) Volume(L) 1 2 3 4 Volume(L) 0 1 2 3 4 0 5 10 15 Flow(L/s) Volume(L) 0 2 4 6 8 10 0 1 2 3 4 time(s) Volume(L) audio flow features measures regression curve regression lung function FEV1 FVC PEF Wednesday, September 11, 13
  71. 71. 0 1 2 3 4 5 6 7 −1 −0.5 0 0.5 1 time(s) amplitude flow features Wednesday, September 11, 13
  72. 72. 0 1 2 3 4 5 6 7 −1 −0.5 0 0.5 1 time(s) amplitude flow features vocal tractsource output frequency(Hz) 1 2 3 4 5 6 0 500 1000 1500 2000 2500 Wednesday, September 11, 13
  73. 73. 0 1 2 3 4 5 6 7 −1 −0.5 0 0.5 1 time(s) amplitude flow features 0 1 2 3 4 5 6 7 −1 −0.5 0 0.5 1 time(s) amplitude envelope detection 0 1 2 3 4 5 6 7 −1 −0.5 0 0.5 1 time(s) amplitude resonance tracking 0 1 2 3 4 5 6 7 −1 −0.5 0 0.5 1 lpc8raw time(s) amplitude flow estimation features vocal tractsource output 0 1 2 3 4 5 6 7 −1 −0.5 0 0.5 1 lpc8raw time(s) amplitude auto-regressive estimate frequency(Hz) 1 2 3 4 5 6 0 500 1000 1500 2000 2500 Wednesday, September 11, 13
  74. 74. curve regression −1 0 1 2 3 4 5 0 0.1 0.2 0.3 0.4 time(s) featurevalue 0 1 2 3 4 5 0 0.1 0.2 0.3 0.4 time(s) featurevalue feature 1 feature N windowedmachine learningregression ... Wednesday, September 11, 13
  75. 75. −1 0 1 2 3 4 5 0 2 4 6 8 time(s) flow(L/s) curve regression −1 0 1 2 3 4 5 0 0.1 0.2 0.3 0.4 time(s) featurevalue 0 1 2 3 4 5 0 0.1 0.2 0.3 0.4 time(s) featurevalue feature 1 feature N curve output windowedmachine learningregression ... Wednesday, September 11, 13
  76. 76. results measures regression Wednesday, September 11, 13
  77. 77. results measures regression Wednesday, September 11, 13
  78. 78. curve regression −2 0 2 4 6 0 5 10 15 volume(L) flow(L/s) −1 0 1 2 3 4 0 2 4 6 8 volume(L) flow(L/s) Wednesday, September 11, 13
  79. 79. curve regression −2 0 2 4 6 0 5 10 15 volume(L) flow(L/s) −2 0 2 4 6 0 5 10 15 volume(L) flow(L/s) −1 0 1 2 3 4 0 2 4 6 8 volume(L) flow(L/s) −1 0 1 2 3 4 0 2 4 6 8 volume(L) flow(L/s) Wednesday, September 11, 13
  80. 80. curve regression −2 0 2 4 6 0 5 10 15 volume(L) flow(L/s) −2 0 2 4 6 0 5 10 15 volume(L) flow(L/s) −2 0 2 4 6 0 5 10 15 volume(L) flow(L/s) −1 0 1 2 3 4 0 2 4 6 8 volume(L) flow(L/s) −1 0 1 2 3 4 0 2 4 6 8 volume(L) flow(L/s) Wednesday, September 11, 13
  81. 81. curve regression −2 0 2 4 6 0 5 10 15 volume(L) flow(L/s) −2 0 2 4 6 0 5 10 15 volume(L) flow(L/s) −2 0 2 4 6 0 5 10 15 volume(L) flow(L/s) −2 0 2 4 6 0 5 10 15 volume(L) flow(L/s) −1 0 1 2 3 4 0 2 4 6 8 volume(L) flow(L/s) −1 0 1 2 3 4 0 2 4 6 8 volume(L) flow(L/s) Wednesday, September 11, 13
  82. 82. can SpiroSmart curves be used for diagnosis? Wednesday, September 11, 13
  83. 83. survey Wednesday, September 11, 13
  84. 84. • 10 subjects curves survey Wednesday, September 11, 13
  85. 85. • 5 pulmonologists • 10 subjects curves survey Wednesday, September 11, 13
  86. 86. • 5 pulmonologists • 10 subjects curves • unaware if from SpiroSmart / spirometer survey Wednesday, September 11, 13
  87. 87. Wednesday, September 11, 13
  88. 88. Wednesday, September 11, 13
  89. 89. Wednesday, September 11, 13
  90. 90. Wednesday, September 11, 13
  91. 91. Wednesday, September 11, 13
  92. 92. results normal minimal obstructive mild obstructive moderate obstructive severe obstructive restrictive inadequate Wednesday, September 11, 13
  93. 93. results normal minimal obstructive mild obstructive moderate obstructive severe obstructive restrictive inadequate identical 64% Wednesday, September 11, 13
  94. 94. results normal minimal obstructive mild obstructive moderate obstructive severe obstructive restrictive inadequate one off 10% identical 64% Wednesday, September 11, 13
  95. 95. results normal minimal obstructive mild obstructive moderate obstructive severe obstructive restrictive inadequate one off 10% identical 64% Wednesday, September 11, 13
  96. 96. results normal minimal obstructive mild obstructive moderate obstructive severe obstructive restrictive inadequate false positive 14% one off 10% identical 64% Wednesday, September 11, 13
  97. 97. results normal minimal obstructive mild obstructive moderate obstructive severe obstructive restrictive inadequate false negative 4% false positive 14% one off 10% identical 64% Wednesday, September 11, 13
  98. 98. results normal minimal obstructive mild obstructive moderate obstructive severe obstructive restrictive inadequate error 8% false negative 4% false positive 14% one off 10% identical 64% Wednesday, September 11, 13
  99. 99. results normal minimal obstructive mild obstructive moderate obstructive severe obstructive restrictive inadequate error 8% false negative 4% false positive 14% one off 10% identical 64% abnormal vs normal 96% Wednesday, September 11, 13
  100. 100. appropriate for screening and early diagnosis Wednesday, September 11, 13
  101. 101. appropriate for screening and early diagnosis in the home? in the developing world? Wednesday, September 11, 13
  102. 102. Wednesday, September 11, 13
  103. 103. in 10 years, COPD will surpass AIDS/HIV as cause of death in developing nations Wednesday, September 11, 13
  104. 104. in 10 years, COPD will surpass AIDS/HIV as cause of death in developing nations Wednesday, September 11, 13
  105. 105. future research lung function jaundice Wednesday, September 11, 13
  106. 106. future research lung function jaundice Wednesday, September 11, 13
  107. 107. Wednesday, September 11, 13
  108. 108. Wednesday, September 11, 13
  109. 109. Wednesday, September 11, 13
  110. 110. Wednesday, September 11, 13
  111. 111. Wednesday, September 11, 13
  112. 112. Wednesday, September 11, 13
  113. 113. Wednesday, September 11, 13
  114. 114. Wednesday, September 11, 13
  115. 115. Wednesday, September 11, 13
  116. 116. Wednesday, September 11, 13
  117. 117. Wednesday, September 11, 13
  118. 118. Wednesday, September 11, 13
  119. 119. Wednesday, September 11, 13
  120. 120. Wednesday, September 11, 13
  121. 121. neonatal jaundice in the US kernicterus: 21 hazardous jaundice: 1158 extreme jaundice: 2,317 severe jaundice: 35,000 phototherapy: 290,000 visible jaundice: 3.5 million births/year: 4.1 million Wednesday, September 11, 13
  122. 122. Method Accuracy Disadvantages TSB Gold standard (r=1.0) Painful, costly, inconvenient, delayed TcB Accurate (r= 0.75 -0.93) Meter = $7000 tips $5 unavailable in most physician offices Visual assessment (provider or parent) not accurate (r= 0.36 - 0.7), underestimates severity No standardization lighting, pigmentation Wednesday, September 11, 13
  123. 123. Wednesday, September 11, 13
  124. 124. bilicam Wednesday, September 11, 13
  125. 125. Wednesday, September 11, 13
  126. 126. participants 40 0-4 days old, collected in nursery0-4 days old, collected in nursery study a Wednesday, September 11, 13
  127. 127. participants 40 0-4 days old, collected in nursery0-4 days old, collected in nursery study a Wednesday, September 11, 13
  128. 128. Color Linearization • Camera Settings Adjustment • Light Source Estimation Image Segmentation • Quality Control for Distance, Lighting, and Shadow • Sternum, Forehead, Card Segmented Color Calibration • Dynamic Least Squares Regression • Automatic Feature Selection Neonatal Skin Response to Bilirubin • Skin Independent Color Transformations Applied • Multivariate Machine Learning Regression bilicam Wednesday, September 11, 13
  129. 129. 051015 TcBvalues 0 5 10 15 bilicam values Fitted values bilicam bilirubinlevel bilicam estimation 0 15 155 10 5 10 mg/dl r=0.91 bilicam initial results Wednesday, September 11, 13
  130. 130. Wednesday, September 11, 13
  131. 131. • near term: screening Wednesday, September 11, 13
  132. 132. • near term: screening • medium term: TSB study Wednesday, September 11, 13
  133. 133. • near term: screening • medium term: TSB study • long term: developing world Wednesday, September 11, 13
  134. 134. • near term: screening • medium term: TSB study • long term: developing world “in many resource poor nations, hyperbilirubinemia is the second or third leading cause of infant mortality and disability” Wednesday, September 11, 13
  135. 135. future research lung function jaundice Wednesday, September 11, 13
  136. 136. future research lung function jaundice Wednesday, September 11, 13
  137. 137. oxygen volume, VO2 Wednesday, September 11, 13
  138. 138. blood pressure Wednesday, September 11, 13
  139. 139. intra ocular pressure Wednesday, September 11, 13
  140. 140. intra ocular pressure Wednesday, September 11, 13
  141. 141. Wednesday, September 11, 13
  142. 142. activity detection elder care daily activity logs congestive heart failure health markers via phone blood pressure pulse oximetry stress opportunistic sensing pain management detecting circulation Wednesday, September 11, 13
  143. 143. activity detection elder care daily activity logs congestive heart failure health markers via phone blood pressure pulse oximetry stress opportunistic sensing pain management detecting circulation developing world Wednesday, September 11, 13
  144. 144. take away • CSE has a large role in the coming evolution of mHealth, equal to doctors • sensing and clinical utility • deploy in clinic, deploy in world, then release • ... look for a new mobile application sensing course ... Wednesday, September 11, 13
  145. 145. eric c. larson | eclarson.com interdisciplinary computer science and engineering mobilizing mhealth Assistant Professor Computer Science and Engineering eclarson.com eclarson@lyle.smu.edu @ec_larson Thank You! Wednesday, September 11, 13

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