2. Unique Surgical Approach Clinically Safe and Effective
EsophyX TIF Front LineSurgicalManagement
“Front Line Surgical Management” EsophyX™ Getting it Right
Mild
Mild GERD
GERD
Severe
Severe GERD
GERD 85% of patients remain off daily PPIs one year after EsophyX™ TIF 85%
Lifestyle Change Pharmaceutical Surgical
• Less invasive, no incision or dissection
The TIF surgical procedure using the advanced surgical instrumentation of EsophyX you are able to have • Reducing Hiatal Hernias less than 2 cm
now a FRONTLINE SURGICAL MANAGEMENT of GERD. The EsophyX device enables surgeons and advanced
interventional gastroenterologists to offer their patients substantive anatomical repair without incisions
• Stopping and reducing esophagitis
(no skin or internal dissection) to intervene earlier and change patients lives. • Significantly improving patient quality of life
EsophyX™ Advantages *P < 0.01 N = 65
Transoral Approach - TIF Surgical Procedure
• Transoral truly non-invasive, incisionless
• TIF is an evolution of current surgical procedures
• Based upon proven surgical principles
• TIF has the ability to “reconstruct” the major
components of the antireux barrier
• Adaptable, repeatable, adjustable
• Future options not limited The EsophyX™-TIF1.0 procedure resulted in a 53% increase (P<0.001) in
• Serosa-to-serosa fusion mean LES resting pressure (18 mm Hg post-TIF vs. 13 mm Hg pre-TIF)
Delivers similar benets of time proven surgical laparoscopic fundoplication
Vector Volume
In TIF 2.0, the esophagus “emerges” from the repair reecting the
fact that the stomach has been wrapped around the esophagus. The
appearance and location of this valve relative to the EGJ on vector
volume analysis is very similar to that seen for Nissen fundoplication. 12 mo Post - TIF Pre - TIF off PPIs
Reference: Stein HJ, DeMeester TR, Naspetti R, Jamieson J, Perry RE. Three-dimensional
imaging of the lower esophageal sphincter in gastroesophageal reux disease. Ann
Surg 1991; 214; 374-383.
12 months after the EsophyX™ TIF1.0 procedure, 40-65% of patients were able to consume all foods that trigger
heartburn without symptoms while off their PPIs in comparison to 5-40% of patients before the procedure.
Nissen vs. TIF 2