Scientists Develop Polygenic Test for Coronary Artery Disease Risk

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An accomplished cardiologist, Dr. Rajan Bhatt cares for patients at Spectrum Dermatology & Vein Center in Scottsdale, Arizona. Dr. Rajan Bhatt is also a respected clinical researcher and has published peer-reviewed papers on studies he has conducted on coronary artery disease and related conditions.

Health & Medicine

Scientists
Develop
Polygenic
Test for
Coronary
Artery
Disease Risk
RAJAN BHATT

Introduction
 An accomplished cardiologist, Dr. Rajan Bhatt cares for
patients at Spectrum Dermatology & Vein Center in
Scottsdale, Arizona. Dr. Rajan Bhatt is also a respected
clinical researcher and has published peer-reviewed papers
on studies he has conducted on coronary artery disease and
related conditions.
In January of 2018, the journal Circulation: Cardiovascular
Genetics published an article on the development of a
polygenic risk test for coronary artery disease. Researchers at
Laval University, McMaster University, and the Population
Health Research Institute (PHRI) in Canada created the
metric, based on their review of the genotypes of more than
111,000 subjects in the UK Biobank.

Coronary Artery Disease Risk
 From this information, the team identified 182 genetic
variants linked to coronary artery disease.
Using the resultant polygenic risk score, known as GRS182,
the team found that higher numbers correlated with the
development of early-onset coronary artery disease
(EOCAD). The association proved comparable to, yet
independent from, other risk factors, which indicated that
polygenic testing can be a clinically useful tool for risk
evaluation. Researchers suggest that when combined with
currently available genetic testing, polygenic testing can
contribute to a 500 percent increase in identified cases of
EOCAD.

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Dr. Rajan Bhatt is the founder and chief executive officer of Spectrum Dermatology, Spectrum Plastic Surgery, and Valley Surgery Center in Scottsdale, Arizona. For more than a decade, the double-certified cardiologist and internal medicine specialist has used modern technological advancements to deliver the best patient care outcomes. Dr. Rajan Bhatt maintains membership in the American Heart Association (AHA). AHA has been at the forefront of battling heart disease and stroke for more than a century. Bringing together more than 40 million volunteers, AHA relies on donations to run initiatives that help save and improve lives. Donations to AHA support research, boost patient care, access vulnerable populations, and promote better health. The Paul Dudley White Legacy Society brings together generous donors who support AHA through their trusts, wills, and other estate plans. The society is named after Dr. Paul Dudley White, an AHA founding member who served as the personal cardiologist to President Dwight Eisenhower and helped him fully recover from a heart attack. Thanks to Dr. Paul Dudley White’s vision for improving treatment, research, and education on cardiovascular ailments, the White Legacy Society has achieved tremendous success. Participation enables members to be part of a shared vision with like-minded individuals working to eliminate heart disease and stroke. In appreciation of their donations, Paul Dudley White Legacy Society members receive a certificate of recognition, an exclusive lapel pin, a Legacy of Heart newsletter subscription, the opportunity to honor a loved one, and a 10-percent discount from shopheart.org (AHA’s online store).

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An alumnus of the University of California and the University of Arizona School of Medicine, Dr. Rajan Bhatt is a healthcare leader who serves as CEO of Spectrum Dermatology and Spectrum Plastic Surgery. In addition to the aforementioned healthcare facilities, Dr. Rajan Bhatt also manages a team of healthcare professionals at Valley Surgery Center to provide world-class care to clients. Situated in Scottsdale and greater Phoenix, the accredited patient surgery center Valley Surgery Center offers premium care to patients through its outstanding team of board-certified anesthesiologists who are devoted to quality service and accomplishing the best outcomes. The experts in the center are fully aware of the potential complications of each procedure and ensure that possible chances of such complications are mitigated through patient-centered practice. While each surgical procedure entails gold standard steps that should be done in the same manner every time, Valley Surgery Center welcomes and treats each patient in a unique way. The team understands that the requirement of each patient before, during, and after surgery typically varies for the best outcomes. The team takes the further steps involved in satisfying this requirement to ensure safety during the procedure and treatment.

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An alumnus of the University of Arizona School of Medicine, Dr. Rajan Bhatt leverages more than a decade of medical and leadership experience to guide Spectrum Dermatology, Spectrum Plastic Surgery, and the Valley Surgery Center in Scottsdale, Arizona. In his executive capacity at Spectrum Dermatology, Dr. Rajan Bhatt founded the center in 2012 to provide treatments for a range of skin conditions such as brown spots. Board-certified dermatologists at Spectrum Dermatology take great pleasure in accurately diagnosing a wide range of skin disorders and recommending a treatment plan for each patient. "Brown spots" is one of the most prevalent conditions encountered at Spectrum Dermatology. Brown spots, also known as seborrheic keratosis (SK), are benign lesions, hyperpigmentation, or aging spots that are normally harmless. They can appear in a number of forms, including velvety, glossy, or wart-like textures that thicken relatively to the surrounding skin. They may also grow in size and appear darker over time. Seborrheic keratosis has no exact cause, but some family members are more susceptible to brown spots, suggesting a genetic factor. Also, many seniors develop brown spots as signs of aging. Spending a lot of time in the sun can also contribute to the development of seborrheic keratosis. Regardless of the cause, these abnormal growths are noncancerous. However, in a few cases, seborrheic keratosis may be warning signs of cancer, particularly when multiple brown spots appear suddenly. It's ideal to see a healthcare provider if this happens.

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Dr. Rajan Bhatt completed an MBA from the Peter Drucker Graduate School of Management in Los Angeles, California. At Spectrum Dermatology and Vein Center in Scottsdale, Arizona, Rajan Bhatt is a cardiologist. Spectrum Dermatology and Vein Center's services include treatment for actinic keratosis (AK). Actinic keratosis is caused by prolonged, unprotected exposure to UV radiation, which is why AK is often formed in sun-exposed regions of the skin. The effects of the sun on the skin build up over time. This implies that the more time you spend in the sun for years, even if it's just for brief periods, the more likely you are to get AK. Indoor tanning beds emit UV rays that are particularly harmful in increasing the chance of developing AK and other forms of skin cancer. Anyone who spends a lot of time outside without protection, regardless of the climate, is at risk of getting AK. Your chance of getting AK is increased if your immune system has been impaired by medical treatments such as immunosuppressive treatment or chemotherapy or if you have a medical illness such as lymphoma, leukemia, or HIV that causes immunological dysfunction. UV radiation weakens the immune system, making it less capable of repairing additional damage. Although anybody may get AK, those with fair skin, particularly those with red or blond hair, skin that freckles or burns easily, or blue or green eyes are at a greater risk.

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A member of the American College of Cardiology and the American Heart Association American College of Physicians, Dr. Rajan Bhatt is a skilled cardiologist double board-certified in internal medicine and cardiovascular disease and practices medicine in Scottsdale, Arizona. Additionally, Dr. Rajan Bhatt oversees a team of medical professionals at Spectrum Dermatology, which provides preventative treatments for various skin disorders, including warts. Warts are abnormal skin growths that most commonly develop on the fingers and toes but can occur elsewhere in the body. The human papillomavirus, or HPV, causes warts. Children are more likely to get warts because their immune systems are not as robust as adults'. People usually get warts by contracting them from another person. Some people are more susceptible to warts by nature than others. Direct contact with the virus may transmit it, and shaking many people's hands is a typical occurrence. Warts are transmitted by cuts that come into touch with the virus. The infection can be started by any tiny wound, such as a hangnail or shaving nick. Although warts are harmless, many individuals want them removed. They're also very infectious, so getting these pimples properly removed as soon as possible is a good idea. Depending on the location and kind of skin, dermatologists have a few choices for treating warts. One of the most common options is to use liquid nitrogen to freeze the wart. It is sometimes preferable to burn the wart off. For particularly persistent warts, a dermatologist may use a laser. In some cases, cantharidin, a specific chemical, is used to cause the skin to blister and fall off.

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A board-certified cardiologist and CEO, Dr. Rajan Bhatt draws on more than a decade of experience leading several healthcare facilities in Arizona, including Spectrum Dermatology and Spectrum Plastic Surgery. Dr. Rajan Bhatt guides the former in providing skin care treatments and post-treatments using various therapies such as microneedling sessions and operations. Spectrum Dermatology utilizes the Bellus Medical SkinPen for every microneedling operation. The SkinPen is the only FDA-approved device with a completely closed system that eliminates the potential human errors from the operation, resulting in even better outcomes. In addition, the disposable cartridges of the Bellus Medical SkinPen remove the risk of cross-contamination, making it the safest microneedling device. Microneedling is a non-invasive, non-surgical FDA-approved therapy for face scarring, sagging, fine lines, and wrinkles. It can transform damaged face tissue into skin that is brighter, clearer, and younger-looking. Skin shines after a session, and makeup wearers will notice that the outcomes are more natural and seamless.

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Throughout his career, cardiologist Dr. Rajan Bhatt has published several peer-reviewed research papers investigating echocardiography and gastroenterology. In addition to his contributions to the medical field, Dr. Rajan Bhatt also serves as CEO of Spectrum Dermatology, a specialty clinic based in Scottsdale, Arizona. The clinic treats multiple dermatological conditions, including skin lesions. Many people develop large brown lesions on their skin as they age. In medical terms, these benign spots are known as seborrheic keratoses. They usually appear in clusters on the back, abdomen, or scalp and have a waxy texture. While they may resemble moles, they do not have the same ability to become cancerous. However, they can grow and darken over time. For this reason, it can be difficult to distinguish between melanoma, a skin cancer, and seborrheic keratosis by sight alone. In this case, patients can request a biopsy from their dermatologist. The causes of seborrheic keratosis are not well understood, but they are hereditary. Pregnant women or people undergoing hormone therapy also have a higher chance of developing seborrheic keratosis. Patients may want these spots removed for cosmetic reasons. Doctors may also recommend removal if the spot becomes irritated and sensitive.

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Arizona-based executive Rajan Bhatt holds an MD and MBA degree. The author of several professional publications, he leads Spectrum Dermatology, Spectrum Plastic Surgery, and Valley Surgery Center as founder and CEO. At Spectrum Dermatology, Rajan Bhatt’s team provides a range of services, including surgical dermatology procedures like Mohs surgery, a special technique that removes skin cancers. Although Mohs surgery, or Mohs micrographic surgery (MMS), is a long procedure due to the microscopic analysis it requires, healing from the procedure is relatively simple and uneventful. Immediately following the procedure, patients feel tired. During this time, it’s advised that they rest as much as possible and avoid any strenuous activity, like bending. At the same time, they must pay attention to the bandage placed at the surgical site. Most physicians ask that the bandage is left on for 24 to 48 hours. After that time, patients remove the bandage and use whatever wound care their physician recommends. Since the surgical site is either stitched closed, left alone, or has a skin flap or graft placed over it after surgery, the specific wound care requirements vary. Most patients do not experience pain when healing from Mohs surgery. However, those that do have minor discomfort or light bleeding must manage the issue with over-the-counter medications before the pain becomes unbearable. Physicians rarely prescribe pain medication for MMS, but they may prescribe antibiotics. Stitches are removed four to 14 days following the surgery, if they were used when closing the surgical site. Patients are then free to return to normal activities, unless their physician advises that they wait longer. Full recovery may take a few weeks.

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An experienced cardiologist, Dr. Rajan Bhatt founded Spectrum Dermatology a decade ago in Scottsdale, Arizona. Dr. Rajan Bhatt maintains membership in a number of cardiology-related groups, including the American Society of Echocardiography (ASE). A professional association dedicated to advancing education, research, and patient outcomes in the field of cardiovascular ultrasound, ASE has a unique structure that includes multiple specialty interest groups (SIGs). These SIGs allow professionals in highly specialized fields to network and learn the latest developments in their fields. The current groups include critical care echocardiography, interventional echocardiography, neonatal hemodynamics, and emerging echo enthusiasts. ASE has a process for establishing new SIGs that can be proposed by any member. The formation of a new group requires only that two existing ASE members are willing to fill leadership roles for their group. The leaders must be experts in their field and hold the appropriate designations and credentials for their specialty area.

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Dr. Rajan Bhatt is the founder of Spectrum Dermatology in Scottsdale, Arizona. Also the founder of Spectrum Plastic Surgery and Valley Surgery Center, Dr. Rajan Bhatt completed his cardiology fellowship at the University of Arizona (UA) Sarver Heart Center. Part of UA’s College of Medicine in Tucson, Arizona, the Sarver Center is home to the Molecular Cardiovascular Research Program (MCRP), which conducts in-depth studies of the biological and molecular workings of the heart and lungs to help doctors better understand cardiovascular disease. The center employs around 150 scientists and clinicians who specialize in cardiovascular disease. The researchers and practitioners share data and breakthroughs across the laboratory and clinical settings. “We go from bench to bedside and back to bench,” said MCRP Director Carol Gregorio, PhD, describing the relationship between clinicians and scientists. MCRP researchers also collaborate with bioscientists from UA’s nearby BIO5 Institute and with colleagues on the UA Health Sciences Campus.

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For nearly 15 years, Dr. Rajan Bhatt has served as a cardiologist at the Spectrum Vein Center in Scottsdale, Arizona. In addition to working with patients on a daily basis, he is also a committed researcher and author in his field, penning numerous articles that have been featured in peer-reviewed medical journals. Another way Dr. Rajan Bhatt contributes to his field is through membership in professional organizations, such as the American College of Cardiology.

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