Brief review of thyroid chapter

1. Robbins Review
The Thyroid Gland-
Neoplasms
Dr. Sameera Rashid
PGY-3 Anatomical Pathology

3. Cuboidal to low
columnar epithelium
filled with pink,
homogenous PAS
positive
thyroglobulin.

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11. PTC- Variants
▪ Papillary microcarcinoma: a focus of PTC less than 1 cm in maximum
diameter.

13. PTC –Oncocytic
variant
Papillary structures at least
focally, may be mixed with
follicular growth pattern
Predominantly oncocytic
cytoplasm but papillary
nuclear features
May be encapsulated or
invasive.

15. Noninvasive follicular thyroid neoplasm with
papillary-like nuclear features (NIFTP)
Major features:
Encapsulation or clear demarcation
Follicular growth pattern with less than 1%
papillae
If solid, trabecular or insular patterns seen;
these in total should be less than 30% of the
total tumor volume
No psammoma bodies
Nuclear features of papillary thyroid
carcinoma (enlargement, crowding /
overlapping, elongation, irregular contours,
grooves, pseudoinclusions, chromatin
clearing), nuclear score should be 2 or 3
Excellent prognosis

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17. Follicular adenoma of the thyroid
▪ Benign, encapsulated, clonal.
▪ Monotonous follicular/trabecular
arrangement.
▪ No Capsular or vascular invasion.
▪ R/F radiation exposure, Cowden
disease, Carney complex.

18. Follicular Carcinoma
• 10-15 % of all thyroid malignancies.
• Minimally invasive: well
encapsulated (excellent prognosis)
• Widely invasive:not encapsulated,
widely invasive.( poorer prognosis)

19. Follicular adenoma Vs Follicular
carcinoma

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23. Medullary Carcinoma

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28. Anaplastic (differentiated) carcinoma
▪ Extremely aggressive
▪ Pleomorphic glands with
epithelial, spindle, giant cells
and necrosis.
▪ R/F iodine def, radiation
exposure, pre-existing thyroid
disorder.

29. Poorly differentiated (insular)
carcinoma
▪ Solid / trabecular / insular
growth pattern
▪ No nuclear features of papillary
carcinoma
▪ Presence of at least one of
following: convoluted nuclei,
3+ mitotic figures / 10 HPF,

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