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steroids.pptx
1. Nomenclature of Steroids
Presented by
Divya Dhule
M.Pharm.(Pharmaceutical Chemistry) 1st year
Department of Pharmaceutical Sciences,
Rashtrasant Tukadoji Maharaj Nagpur university,
Nagpur
4. Consist of 4 rings A, B, C & D.
Completely saturated derivative.
A, B, C = Cyclohexane
D= Cyclopentane
Basic Skeleton= 17 C
Numbering Start from A– B– C–D.
Additional carbons present at C10 and C13.
Alkyl substituents on C17
Methyl groups at C10 & C13 = Angular methyl groups.
6. Double bond ane = ene
1 double bond =ene
2 double bond= diene
3 Double Bond = triene
You can simply
Represent (=) by giving
numbering of that
position. (17β)-estra-1,3,5(10)-triene-3,17-diol
7. Double bond position
denoted by Δ (Delta).
C4=C5 –--Δ 4
C5= C10 ----Δ 5(10)
If 3 membered ring =
Prefix Cyclo with
Respective position no.
8. Compounds with
5 α Cholestane = Allo series[fig.1]
5 β Cholestane = normal series
Fig. 1 5 α Cholestane Fig. 2 5 β Cholestane
9. Any enlargement in ring then capital letter
of ring with ‘Homo’.
Eg.A-homo , B-homo etc
Methyl group is missing = prefix ‘nor’
Methyl group at C13 and C10 are always
in beta configurations so no need to write
it in name of steroids.
Substituent position no. should be write.
Nor Androsterone