1. PubMed Results<br />Item 1 of 1<br />1.Eur Neuropsychopharmacol. 2010 May;20(5):301-9. Epub 2009 Oct 24.Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression.Domschke K, HYPERLINK quot;
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Dannlowski%20U%22%5BAuthor%5Dquot;
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Dannlowski U, HYPERLINK quot;
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Hohoff%20C%22%5BAuthor%5Dquot;
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Hohoff C, HYPERLINK quot;
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Ohrmann%20P%22%5BAuthor%5Dquot;
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Ohrmann P, Bauer J, HYPERLINK quot;
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kugel%20H%22%5BAuthor%5Dquot;
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Kugel H, HYPERLINK quot;
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Zwanzger%20P%22%5BAuthor%5Dquot;
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Zwanzger P, HYPERLINK quot;
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Heindel%20W%22%5BAuthor%5Dquot;
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Heindel W, HYPERLINK quot;
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Deckert%20J%22%5BAuthor%5Dquot;
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Deckert J, HYPERLINK quot;
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Arolt%20V%22%5BAuthor%5Dquot;
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Arolt V, HYPERLINK quot;
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Suslow%20T%22%5BAuthor%5Dquot;
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Suslow T, HYPERLINK quot;
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Baune%20BT%22%5BAuthor%5Dquot;
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Baune BT.SourceDept. of Psychiatry, University of Muenster, Germany. katharina.domschke@ukmuenster.deAbstractNeuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety and depression. Thus, NPY is a promising candidate in the investigation of the clinical phenotype of quot;
anxious depressionquot;
. Five NPY gene variants were investigated for an influence on antidepressant treatment response in a sample of 256 patients with depression. Additionally, NPY gene impact on amygdala activation during facial emotion processing was analyzed in a subsample of 35 depressed patients. Particularly in anxious depression, the less active NPY rs16147 -399C allele conferred slow response after 2weeks and failure to achieve remission after four weeks of treatment. The rs16147 C allele was further associated with stronger bilateral amygdala activation in response to threatening faces in an allele-dose fashion. The present results point towards a possible influence of functional NPY gene variation on antidepressant treatment response in anxious depression, potentially conveyed by altered emotional processing.2009 Elsevier B.V. and ECNP. All rights reserved.PMID:19854625[PubMed - indexed for MEDLINE]<br />