EMPEROR - Reduced Trial

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The EMPEROR-Reduced trial studied the effects of empagliflozin in patients with chronic heart failure with reduced ejection fraction. The trial included patients with NYHA class II-IV heart failure and an ejection fraction below 40% who were receiving standard guideline-directed medical therapy. Patients were randomly assigned to receive empagliflozin 10 mg daily or placebo and followed for a median of 16 months. The study found that empagliflozin reduced the risk of the composite primary outcome of cardiovascular death or hospitalization for heart failure compared to placebo.

Health & Medicine

EMPEROR-Reduced Trial Marta Cobo Marcos
M. Packer presentation ESC 2020

EMPEROR-Reduced Trial Marta Cobo Marcos
2017-2019
M. Packer presentation ESC 2020

$EMPEROR-Reduced Trial Marta Cobo Marcos The study included patients with chronic HF with reduced ejection fraction Key inclusion criteria: • NYHA class II–IV with LVEF ≤40% • Elevated NT-proBNP • Guideline-recommended medication stable ≥1 week prior to first visit • eGFR ≥20 ml/min/1.73 m2 Inclusion Criteria Key inclusion criteria: • NYHA class II–IV with LVEF ≤40% • Elevated NT-proBNP • Guideline-recommended medication stable ≥1 week prior to first visit • eGFR ≥20 ml/min/1.73 m2$

EMPEROR-Reduced Trial Marta Cobo Marcos
Empagliflozin 10 mg qd + SOC
Placebo qd + SOC
Median follow-up: ~16 months
30-day
post-
treatment
period
End of treatment
at 841 primary
outcome events
Trial design

EMPEROR-Reduced Trial Marta Cobo Marcos
“La empagliflozina añadida al tratamiento médico
óptimo disminuye el riesgo de mortalidad
cardiovascular/hospitalización por IC en el paciente
con IC y FE reducida, además de disminuir la
progresión de enfermedad renal”
CONCLUSIONES

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These are simplified slides discussing the regulation of cardiac output and venous return. Learning objectives: 1. Comprehend the determinants of cardiac output and factors affecting cardiac output 2. Comprehend the factors affecting stroke volume and heart rate and total peripheral resistance 3. Identify the factors regulating venous return 4. Discuss the causes of high and low output cardiac failure 5. Enlist the functions of veins and recognise the significance of venous reservoirs Study Resources: 1. Chapter 20, Guyton and Hall Textbook of Medical Physiology, 14th edition 2. Chapter 30 and 32, Ganong’s Review of Medical Physiology, 26th edition 3. Chapter 10, Human Physiology by Lauralee Sherwood, 9th edition 4. Physiology, Cardiac Output - StatPearls https://www.ncbi.nlm.nih.gov/books/NBK470455/

Cardiac Output, Venous Return, and Their Regulation

MedicoseAcademics

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