Antibiotic Induced Sepsis

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Antibiotic-induced Sepsis Amr Badreldin Hamdy MD FCCP

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This is a powerpoint presentation on the Topic of Diseases of the immune system, part 1 - Chapter 6, based on Robbin's textbook of pathology. Prepared by Dr. Ashish Jawarkar, who is Assistant professor at Parul institute of medical sciences and research, Vadodara. Please subscribe to our youtube channel https://www.youtube.com/channel/UCwjkzK-YnJ-ra4HMOqq3Fkw . Our facebook page: facebook.com/pathologybasics. Instagram handle @pathologybasics

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Sepsis which is commonly called as septicemia is one of the most dreadful and vulnerable life threatening disease which is quite uncommon in popularity. Around the world 1.8 million cases and in India there is 30% of nosocomial infectious patients get infected per annum accounted epidemiologically. It happens by gradual steps which is based on the incidence of the physiological and biochemical malfunctions from which septic shock is the last severe step. It is not depend on the single specific pathway dysregulation rather regulated by multi biological pathways. Various malfunctions in regulated systems like paralysis of neutrophils, higher production of proinflammatory products, diversion of adaptive immune cells like TH1 and TH2, apoptosis of lymphocytes and dendritic cells leads to sepsis. Complement anaphylatoxin C5a plays a major mediator of inflammatory response and dysregulation of plasmatic cascade. Disruption of any connecting linkers between the coagulation, complement and fibrinolysis leads to inhibition of anticoagulation mechanism. Adrenergic and cholinergic inflammatory pathway which regulates the inflammatory response get altered. In biochemical point of view endothelial dysfunction occurs mainly due to the formation of reactive oxygen species (ROS) and other components, Properdin level also get downregulated. Although much progress has been made in the treatment of inflammatory disease, the continued high mortality in septic shock is a sobering reflection of current therapeutic approaches. Nevertheless, increased understanding the molecular mechanism of various factors, connecting links and the multi effectors of sepsis can provide for better path to conquer sepsis in maximum ways.

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