4. GROWTH REGULATORS
Compounds which have a different action
from the conventional insecticides
They
a
INSE re also known
as “ I
CT G
R O W GR ”
REG
TH
U
LATO
R
5. “IGRs” CHARACTERISTICS
Interfere with the
metamorphosis and ecdysis
control mechanism.
Act on specific Arthropods
enzymes.
Give a long residual protection.
Act on juvenile forms of insects.
Can cause the adult females to
lay unviable eggs.
They don’t offer the knock
down effect.
6. ACTION MODE - CLASSIFICATION
CHITIN
SYNTHESIS
INHIBITORS
Synthetase enzyme =
responsible for the
chitin formation
process. IGRs
prevent its
polymerization.
Ex.: Flufenoxuron.
AGONISTS OF
ECDYSTEROIDS
JUVENILE
HORMONE AGONISTS
Imitate the insects natural
hormone ("ecdisônio"),
prematurely triggering the
process of change.
"Juvenoid" = Imitate the action
of the insects juvenile
hormone by interfering with
the skin changes.
Ex.: Tefubenoside,
Metoxifenoside.
Ex.: Piriproxifen,
Fenoxicarb, Metoprene.
7. POLYSACCHARIDES
Carbohydrates formed by the union of more
than ten monosaccharide molecules, forming
a polymer of monosaccharides
MONOSACCHARIDES
FRUCTOSE
BETA- GLUCOSE
Energy
Ex.: Starch, Glycogen
Structural
Ex.: Chitin, Cellulose
Unlike the mono-and disaccharides (glucose, galactose, fructose),
polysaccharides are insoluble in water and are well suited to the role of
nutritional reserves or storage.
9. FUNGUS - CELL WALL
mannoproteins
FUNCTIONS
ß (1,3)
Protection adverse
factors
ß (1,6) glucan
Permeability
barrier
ß (1,3) glucan
Plasma membrane
chitin
synthase
Cell shape
ergosterol
Interaction with the
external environment
Atlas of fungal Infections, Richard Diamond Ed. 1999 - Introduction to Medical Mycology. Merck and Co. 2001
10. FLUFENOXURON
Chemical group:
Benzoyl phenyl urea
Solubility in water: 0,0043 mg/l
(25º)
Acute oral DL50(rat):
> 3000 mg/kg (téc.)
85% eliminated in feces within
72 hours (rats)
Not irritanting
Classe III – OMS
11. LABORATORY RESULTS- FLUFENOXURON
Blattella germanica
Until 98 days:
5 mg/m²
M
O
R
T
A
L
I
T
Start with 8 adults (3 males/ 5
females, and 3 with ooteca), and
10 nymphs in 1º ínstar and 5 the
last ínstar.
10 mg/m²
Control
After 100 days:
Y%
New population with 7 adults (3
males/4 females, and 2 with
ooteca), and 7 nymphs in 1º ínstar
and 5 the last ínstar.
Area treated: 10% of the total area disponível.Obs.: Total area
with availability of food, shelter and water.
Food And Environment Protection Act 1985, Part III
12. ESTIMATED POPULATION IN 98 DAYS
Blattella germanica
Biological Characteristics
Domestic Species
Blattella germanica
Size
12 a 16 mm
Color
yellowish brown
Ootheca Deposition
not release
Number of eggs / ootheca
30-40
Number of ootheca
4-5
Number of Ecdysis
5-7
young period
2-3 months
longevity
1 year
eggs incubation
15-30 days
posture interval
45 days
Succession number
20 000
days to produce the first ootheca
17
98 days estimate
5369X 5 – 26.845
13. FIELD RESULTS - FLUFENOXURON
Blattella germanica
%
P
O
P
U
L
A
T
I
O
N
R
E
D
U
C
T
I
O
N
Inicial
on
populati
Index Infestation measured
with glue trap.
(captures per night)
Dose found in the treated surfaces
(chromatographic analysis - mg / m²):
Apart 01:
-
Apart 02: 6,33
Apart 03:
-
Apart 04: 4,53
Rate: 7,5 mg/m²
Food And Environment Protection Act 1985, Part III
Apart 05: 5,24
Apart 06: 3,65
14. FIELD RESULTS - FLUFENOXURON
Blattella germanica
Apart. 02
Nº
I
N
S
E
C
T
S
C
A
P
T
U
R
E
D
Food And Environment Protection Act 1985, Part III
ADULTS
NYMPHS
15. LABORATORY RESULTS – FLUFENOXUROM
Ctenocephalides felis
PUPAE
DEAD LARVAE
TREATMENT
RESULTS WITH
ADULTS - SECOND
STAGE (%)
Control
72,5
62
4
0,8 mg/m²
0,98
38
23
4,0 mg/m²
0
5
68
NUMBER
5 repetitions of 15 to 20 larvae of second ínstar
Flufenoxuron - control in
the development of the
second stage
16. LIFE CYCLE - FLEAS
Ctenocephalides felis
Adults
Pupa
Adult Flea
Eggs
Pupa
Animals
Larvae
Larvae
3º stage
Larvae
1º stage
Environment
Environment
Environment
Larvae
2º stage
LIFE CYCLE
Eggs
Cycle Time - 17 to 25 days
Approximately 3000 eggs
17. FIELD RESULTS - FLUFENOXURON
Ctenocephalides felis
Rate:
Eggs collected
Dead Larvae
15 mg/m²
METHODOLOGY
1)
Cat’s Cloth (40 cm²) jerky
and collected;
Alive Adults
2)
Count number of eggs;
Adults Control (%)
3)
Incubated eggs;
4)
Note the development of
eggs.
Alive Larvae
W
ks
ee
Control with 77 weeks
Food And Environment Protection Act 1985, Part III
18. FLUFENOXURON RECOMMENDATIONS - OMS
Cockroaches: Rate 0,3 g/L
“Due to its slow-acting insecticides are usually combined with faster
acting insectcides. This combination eliminates adults and prevents the
development of young forms”
Bed Bugs: Rate 0,3 g/L
“Studies have shown the bed bugs resistance to conventional
insecticides.The mixtures of Growth Regulators + Pyrethroids have
proven to be an effective control compared to infestations tolerant to
pyrethroids when it is used alone. "
Food And Environment Protection Act 1985, Part III
19. TENOPA® - ESPECIFICATIONS
Physical State:
opaque and
viscous liquid
Color: white
Oxidant:
considered
non oxidizing
Density: 1,028
Smell: Odeurless
Shelf stability
Good stability in:
20 a 28º C - 104 weeks / 728 days
Acid/Base: PH
7.2
29 a 37º C - 52 weeks / 364 days
20. INSTRUCTIONS FOR USE
PESTS
COMERCIAL
PRODUCT
(ml/ 10 L of water)
I.A.
CONCENTRATION
ALPHA-CIPERMETRIN
(%P/P)
I.A.
CONCENTRATION
FLUFENOXURON
(%P/P)
Cockroaches
50
0,015%
0,015%
Mosquitoes
67
0,020%
0,020%
Flies
67
0,020%
0,020%
Fleas
33
0,010%
0,010%
Ants
50
0,015%
0,015%
Triatomines
133
0,040%
0,040%
Ticks
80
0,024%
0,024%
Scorpions
170
0,050%
0,050%
Mealworm
150
0,045%
0,045%
Bed bug
170
0,050%
0,050%
Brown spider
170
0,050%
0,050%
21. LIFE CYCLE - COKROACHES
Periplaneta Americana
Males
Females
22. LABORATORY RESULTS
Tile surface - Blatella germanica
9
8
7
Minutes
6
5
Upper limit
KT50
4
Lower limit
K
IC N
QU TIO
AC
3
2
1
0
Check
Alfa-Cipermetrina 3%+
Flufenoxueom 3%
(TENOPA )
®
Source : Non Crop Laboratory = EEA BASF- Brazil, 2010
Alpha-Cypermethrin
Lambdacyalothrin
Deltamethrin
5%
2,5%
2,5%
23. LABORATORY RESULTS
Wood surface - Blatella germanica
100
90
K
IC N
QU TIO
AC
80
70
Minutes
60
Upper limit
50
KT50
40
Lower limit
30
20
10
0
Check
Alpha-Cypermethrin 3%+ Alpha-Cypermethrin
5%
Flufenoxueon 3%
(TENOPA )
®
Source : Non Crop Laboratory = EEA BASF- Brazil, 2010
Lambdacyalothrin
Deltamethrin
2,5%
2,5%
24. LABORATORY RESULTS
Blatella germanica
TILE SURFACE - tile surface
PRELIMINARY PROFILE
ACTIVE
INGREDIENT
CONC. Appl.
(g a.i./l) (Nº)
RATE
(10l of water)
Alphacypermethrin+
Flufenoxuron
30/30
1
50
1
25
1
25
1
EFFICACY
30 DAYS
EFFICACY
60 DAYS
EFFICACY
90 DAYS
10%
20%
EFFICACY
60 DAYS
EFFICACY
90 DAYS
100ml/200m²
Deltamethrin
EFFICACY
72 HOURS
50ml/200m²
Lambdacyalothrin
EFFICACY
48 HOURS
50ml/200m²
Alphacypermethrin
EFFICACY
24 HOURS
100ml/200m²
Subtitles
WOOD SURFACE
PRELIMINARY PROFILE - wooden surface
ACTIVE
INGREDIENT
CONC. Appl.
(g a.i./l) (Nº)
RATE
(10l of water)
Alphacypermethrin+
Flufenoxuron
30/30
1
50ml/200m²
Alphacypermethrin
50
1
50ml/200m²
Lambdacyalothrin
25
1
100ml/200m²
Deltamethrin
25
1
100ml/200m²
P&D Brasil
Source : Non Crop Laboratory = EEA BASF- Brazil, 2010
EFFICACY
24 HOURS
EFFICACY
48 HOURS
EFFICACY
72 HOURS
0
EFFICACY
30 DAYS
25. RESULTS – RESIDUAL EFFECT
Periplaneta / Blatella
Rate:
50 mL - 10 L of
water
Days
Ecolyzer
ANVISA Standard
26. RESULTS – KNOCK DOWN
Periplaneta / Blatella
Rate:
TIME
50 mL - 10 L of
water
Days
Ecolyzer
ANVISA Standard
KT 50 with confidence interval of 95%
Ex.: Periplaneta - time 24h - result 6,13 min – confidence interval = 4,49/8,35 min
34. 3 1
Single Insecticide = The first
in
on the market:
KNOCK DOWN + RESIDUAL + ACTION
in all the insects phases.
Versatility of the product = Broad spectrum of action
Pyrethroid + IGR = Residual Effecty longer
Active Formulation = For use in the Resistance Management.
Technical Advantage Formulation = To control
cockroaches and Bed Bugs
Differentiated Formulation "SC" = Odorless, water
based, solvent-free organic.
Low toxicity
BASF PRODUCT = DIFFERENTIATED PRODUCT
