Lactic Acidosis & Critical Care - PGIMER

1. LACTIC ACIDOIS
Dr Seran Reddy
Consultant
Critical Care

2. ???
 Lactate & Lactic acidosis
 Major producers and consumers of lactate
 Cori cycle
 Causes of lactic acidosis
 Types of lactic acidosis
 Warburg effect
 Diagnosis
 Treatment
 Role of NaHCO3
 Surviving sepsis guidelines: Bundles

3.  Normal end point of anaerobic breakdown of
glucose in the tissues
 Normal plasma lactate:
➢ Unstressed: 0.5-1 mmol/L
➢ Stressed: < 2 mmol/L
➢ Hyperlactatemia: 2-5 mmol/L
➢ Lactic acidosis: usually > 5 mmol/L with associated
metabolic acidosis

16. Tumour cell

26. Clinical features

34. Cardiogenic shock

40. Septic shock

53. SHOOT YOUR ANSWERS
 Lactate & Lactic acidosis
 Major producers and consumers of lactate
 Cori cycle
 Causes of lactic acidosis
 Types of lactic acidosis
 Warburg effect
 Diagnosis
 Treatment
 Role of NaHCO3
 Surviving sepsis guidelines: Bundles

54. THANK YOU