Which of the following entities can be homozygous? (there may be more than one answer) Please explain why A. Cat B. Cell C. Gene D. Allele E. Chromosome Solution ANS: D. Allele and E. Chromosome. Homozygous: A homozygous trait is made up of two of the same alleles, both dominant (TT) or both recessive (tt). The Homozygous condition only applicable these two options (D. Allele and E. Chromosome) in the given question. Allele: An allele is any of the alternative forms of a gene that may occurs at a specific locus. A homozygous can possess two copies of the same allele, while a heterozygote possesses two different alleles. Homologus Chromosome may... Homozygous: both have the same alleles Heterozygous: both have the different alleles.