2. What are the consequences of mutations for the ability of Hb to perform its function as an O2 transporter? Why? Most mutations (more than one answer is possible): An occasional mutatin: 3. How do mutations in the Hb genes affect fitness at high and low altitudes? Most mutations in Hb genes: Mutations that increase affinity of Hb for O2 in geese living at high altitudes (e.g. bar- headed geese): 2. What are the consequences of mutations for the ability of Hb to perform its function as an O2 transporter? Why? Most mutations (more than one answer is possible): An occasional mutatimn:.