3. Mechanism of Action
• Bactericidal antibiotics
• inhibiting bacterial protein synthesis
• by binding 30 s
• (1) interference with the initiation complex
• (2) misreading of mRNA,
• (3) breakup of polysomes into
nonfunctional monosomes.
4. Therapeutic Uses
• For gram negative aerobic bacteria only
• Urinary tract infections
• Meningitis
• Endocarditis
• Peritonitis
• Septicemia
• Pneumonia
• Gentamicin : Ophthalmic Infections
• Neomycin for Hepatic encephalopathy
• Streptomycin for Tuberculosis (second line)
5. Side Effects
• Nephrotoxicity
• Ototoxicity: Hearing impairment and vestibular toxicity
• Neuromuscular blockade
• Allergic reactions.
• Anemia (low hemoglobin in blood)
• Thrombocytopenia (low platelet count)
