Pulmonary physiology

1. z
Pulmonary
Interstitium
Advance Physiology
Aaron Paul Baliga

2. z
SESSION OUTCOME
At the end of the session, the group must be able to:
1. describe the physiological anatomy of pulmonary
interstitium and;
2. explain the physiological mechanism of pulmonary
Interstitium.

3. z
What is a Pulmonary
Interstitium?

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Interstitium
Thin
portion
Thick
portion

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Thin portion(tight
junction)
– Basal lamina + adjacent
capillary endothelium
– Strict diffusion barrier
between alveolar surface
and underlying tissues

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Thick portion
Collagen: tensile strength
Elastin: flexibility
Proteoglycans:
*Maintain hydration
*Adhesive activity
*Component of growth
factors

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Thick portion
– Tissue fluid
accumulation and
exchange
– Lymphatic drainage
system

10. z
Hydrostatic and osmotic forces in mm Hg at the capillary and alveolar
membrane of the lungs

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OUTWARD FORCES
Capillary pressure
Interstitial fluid
colloid osmotic pressure
Negative interstitial fluid pressure
TOTAL OUTWARD FORCE
7
14
8
29
INWARD FORCE
Plasma colloid oncotic pressure
TOTAL INWARD FORCE
28
MEAN FILTRATION PRESSURE
TOTAL OUTWARD FORCE
TOTAL INWARD FORCE
MEAN FILTRATION FORCES
28
+29
-28
+1

12. z
Left-sided heart failure
or mitral valve disease
Damage of pulmonary
capillary membrane
PULMONARY EDEMA

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14. z
Interstitium
SUPPORTS
THE LUNG
FLUID
BALANCE
REPAIR ,
REMODELLING
and MATRIX
TURN OVER

15. z
Interstitium
Macrophages Fibroblast

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18. z

19. z

20. z
SESSION OUTCOME
At the end of the session, the group must be able to:
1. describe the physiological anatomy of pulmonary
interstitium and;
2. explain the physiological mechanism of pulmonary
Interstitium.