Physiology of Pulmonary System

1. z
Pulmonary
Interstitium
Advance Physiology

2. z
SESSION OUTCOME
At the end of the session, the group must be able to:
1. describe the physiological anatomy of pulmonary
interstitium and;
2. explain the physiological mechanism of pulmonary
Interstitium.

3. z
What is a Pulmonary
Interstitium?

4. z

5. z

6. z
Interstitium
Thin
portion
Thick
portion

7. z
Thin portion(tight
junction)
– Basal lamina + adjacent
capillary endothelium
– Strict diffusion barrier
between alveolar surface
and underlying tissues

8. z
Thick portion
Collagen: tensile strength
Elastin: flexibility
Proteoglycans:
*Maintain hydration
*Adhesive activity
*Component of growth
factors

9. z
Thick portion
– Tissue fluid
accumulation and
exchange
– Lymphatic drainage
system

10. z
Hydrostatic and osmotic forces in mm Hg at the capillary and alveolar
membrane of the lungs

11. z
OUTWARD FORCES
Capillary pressure
Interstitial fluid
colloid osmotic pressure
Negative interstitial fluid pressure
TOTAL OUTWARD FORCE
7
14
8
29
INWARD FORCE
Plasma colloid oncotic pressure
TOTAL INWARD FORCE
28
MEAN FILTRATION PRESSURE
TOTAL OUTWARD FORCE
TOTAL INWARD FORCE
MEAN FILTRATION FORCES
28
+29
-28
+1

12. z
Left-sided heart failure
or mitral valve disease
Damage of pulmonary
capillary membrane
PULMONARY EDEMA

13. z

14. z
Interstitium
SUPPORTS
THE LUNG
FLUID
BALANCE
REPAIR ,
REMODELLING
and MATRIX
TURN OVER

15. z
Interstitium
Macrophages Fibroblast

16. z

17. z

18. z

19. z

20. z
SESSION OUTCOME
At the end of the session, the group must be able to:
1. describe the physiological anatomy of pulmonary
interstitium and;
2. explain the physiological mechanism of pulmonary
Interstitium.