Stability of reconstituted injectable antibiotics  Dilution of antibiotics is an essential part to ensure that patients receive the optimum therapy.  It is important that the concentration of antibiotics ’dilution is correct to minimize the side effects.  This reference is produced to standardize the practice among all pharmacists aiming to provide comprehensive information regarding antibiotics dilution.  I hope this work will be beneficial for you.  You also should follow up of any new developments in the fields.

1. Page1of14
Stability of reconstituted injectable antibiotics
 Dilution of antibiotics is an essential part to ensure that patients receive the optimum therapy.
 It is important that the concentration of antibiotics ’dilution is correct to minimize the side effects.
 This reference is produced to standardize the practice among all pharmacists aiming to provide comprehensive information regarding antibiotics dilution.
 I hope this work will be beneficial for you.
 You also should follow up of any new developments in the fields.
Cell wall synthesis inhibitors
Beta-lactams Carbapenems Monobactams vancomycin semisynthetic
glycopeptide
polypeptide
antibioticspenicillins cephalosporins
Benzathine penicillin ……..p 2
Benzyl penicillin ……..…..p2
Amoxicillin …………..…..p2
Ampicillin ……………...…p3
Amoxicillin + clavulanate ..p3
Ampicillin + Sulbactam ….p3
Amoxicillin + flucloxacillin.p3
Piperacillin + Tazobactam ..p4
Cloxacillin Sodium ……….p4
Cephradine ...p4
Cefuroxime ….p4
Cefoperazone ..p5
Ceftazidime …p5
Ceftizoxime …p5
Cefotaxime ….p6
Ceftriaxone ….p6
Cefepime …....p6
Imipenem + Cilastatin ..p7
Meropenem ………..…p7
Doripenem ………..…p7
Aztreonam …p8 Vancomycin ….p8 Teicoplanin …. P9 Polymycin B ..p9
Protein synthesis inhibitors
Macrolides Aminoglycosides Clindamycin Linezolide Fucidic acid Tetracyclins & glycylcycline
antibiotic that is structurally
similar to tetracycline
Chloramphenicol
Erythromycin …. P9
Azithromycin …..p9
Amikacin ……. P10
Gentamicin ….p10
Streptomycin ….p10
Clindamycin ….. p10 Linezolide ……p11 Fucidic acid..p11 Tigecycline ………p11
Nucleic acid inhibitors
Fluoroquinolones Sulfonamides
Ciprofloxacin ….…..p12
Levofloxacin ……..p12
Moxifloxacin ..…...p12
Sulfamethoxazole + Trimethoprim …p12

2. Page2of14
Medication Diluent IM & IV injection Intermittent IV infusion Stability
Natural penicillins
Benzathine
penicillin
2.4 MIU/5 ml
Retarpen
Depo-pen
Durapen
NA IM injection:
Deep IM into upper outer quadrant
of buttock
Children < 2 year old:
IM into midlateral muscle of thigh
NOT for IV, intra- arterially or
subQ administration
NA Should be freshly prepared.
Benzyl penicillin
1 MIU
5 MIU
(Penicillin G 1 &
5 MIU)
600 mg = 1 MIU
NS
D5W (less stable)
IM injection:
Reconstitute 1 MIU with 1.6 ml
WFI:
Conc. 300 mg/ml
IV injection:
Reconstitute 1 MIU with 5.6 ml
WFI/NS:
Conc. 100 mg/ml
Over 5 minutes.
Max rate: 300 mg/min
Intermittent infusion
Withdraw required dose and further
dilute with diluents. Usually 100 ml NS
6 mg/ml
Over 30-60 minutes
Should be freshly prepared.
Broad spectrum penicillins
Amoxicillin
Amoxil 1 gm
Biomox
250mg, 500 mg, 1
gm
E-mox
250mg, 500 mg, 1
gm
Farconcil
250mg, 500 mg, 1
gm
D5W
NS
Ringer’s Solution or
Compound Sodium
Lactate
IM injection
Add 1.5 mL WFI to … 250-mg
Add 2.5 mL WFI to ….500-mg
If pain occurs, 1% lidocaine may be
used
Do not use the 1-g vial for IM use
(two separate 500-mg injections
should be given if a 1-g dose is
required).
IV injection
Reconstitute each
250-mg …..with 5 mL WFI
500-mg …. with 10 mL
1-g ………. with 20 mL
over 3--4 minutes.
Intermittent IV infusion
Withdraw the required dose and add to a
suitable volume of NaCl 0.9% (usually
100 mL)
- Infuse over 30 – 60 minutes.
- Conc. 5mg/ml
- Continuous Infusion not recommended.
Should be freshly prepared

3. Page3of14
Ampicillin 500 mg
Epicocillin
NS
Incompatible with
D5W &
Hartmann’s
IM injection:
Reconstitute 500 mg with 1.8 ml
WFI:
Conc. 250 mg/ml.
IV injection:
Reconstitute 500 mg with 5 ml WFI:
Conc. 100 mg/ml
Over 3-5 min
Intermittent IV infusion: Withdraw
required dose and add to suitable
volume of diluents.
Dose ≤ 1g to 50 ml Dose >1g to
100 ml
Over 30-60 min
Reconstituted vials: Used
immediately
IM & IV injection:
Use within 1 hr after preparation.
Prepared infusion in NS:
8 hrs ……….... (RT)
12 hrs ……….. (2-8ºC)
Beta-lactam/Beta-lactamase Inhibitor Combinations
Amoxicillin 1 g +
Clavulanate 200
mg
Augmentin
Curam
Magnabiotic
Megaclavox
NS
Ringer’s Solution
Ringer’s Lactate
Water for injection
Incompatible with
D5W
Not suitable for I. M.
IV injection:
Dissolve 600mg with 10ml WFI:
Conc. 60 mg/ml
Infuse over 3 – 4 minutes.
Reconstitute 1.2 g with 20 ml WFI:
Conc. 60 mg/ml
Infuse over 3 – 4 minutes.
Intermittent IV infusion:
Withdraw required dose and further
dilutes to with diluents.
Dose 600 mg in 50 ml NS
Conc. 12 mg/ml
Infuse over 30 – 40 minutes.
Dose 1.2 g in 100 ml NS
Conc. 12 mg/ml
Infuse over 30 – 40 minutes
Reconstituted vials &
prepared infusion:
Used immediately.
4 hrs in ….. 25°C
8 hrs in ….. 2-8 °C
Ampicillin 1 g +
Sulbactam
Sodium 500 mg
Ampictam
Fortibiotic
Sulbin
Unictam
Unasyn
NS
D5W
0.5% or 2%
lidocaine
hydrochloride
for IM
administration
only
IM injection:
375 mg …….. 0.8 ml WFI
750 mg …….. 1.6 ml WFI
1500 mg …… 3.2 ml WFI
3000 mg …… 6.4 ml WFI
Conc. 375 mg/ml
IV injection:
750 mg …….. 25 ml WFI
1500 mg …… 50 ml WFI
3000 mg …… 100 ml WFI
Over 10-15 min
Intermittent IV infusion:
Withdraw required dose and further
dilute with 50 – 100 ml diluent.
Over 15 - 30 min
Prepared IM/ IV injection: Use
within 1 hr after preparation
Prepared infusion in NS:
8 hrs ………..…. (RT)
72 hrs …………. (2-8ºC)
Prepared infusion in D5W:
2 hrs ………….. (RT)
4 hrs ……………(2-8ºC)
Amoxicillin +
flucloxacillin
500 mg, 1gm
Flumox
Flucamox
NS
D5W
IM injection:
500-mg …. with 2 mL
1-g ………. with 4 mL
IV injection:
500-mg …. with 5 mL
1-g ………. with 10 mL
Over 3-4 min
Intermittent IV infusion:
500-mg …. with 10 mL
1-g ………. with 20 mL
Infuse over 30 – 40 minutes
Reconstituted vials: Used
immediately
24 hrs …………. (2-8ºC)

4. Page4of14
Piperacillin 4 g +
Tazobactam 500
mg
Pipracil
Tazocin
NS
D5W
Incompatible with
Hartmann’s
IM injection:
Not recommended
IV injection:
Reconstitute 4.5 g with 20 ml WFI/
NS. At least over 3-5 min
Intermittent IV infusion:
Withdraw required dose and further
dilute with diluents. Usually 50-100 ml
NS
over 20-30 min
Should be used immediately.
or 12 hours at 2-8°C.
Beta-lactamase-Resistant Penicillins
Cloxacillin
Sodium 500 mg
D5W
NS
IM injection:
Reconstitute 500 mg with WFI
2 ml, 250 mg/ml
4 ml, 125 mg/ml
Conc. 125 or 250 mg/ml
IV injection:
Reconstitute 500 mg with WFI
5 ml, 100 mg/ml
10 ml, 50 mg/ml
Conc. 50 or 100 mg/ml
Over 3 - 4 min
IV infusion:
Reconstitute 500 mg with 5 ml WFI:
Conc. 100 mg/ml.
Withdraw required dose and further dilute
with diluents.
Dose ≤ 500 mg to 250 ml
Dose >500 mg to 500 ml
1-2 mg/ml
Reconstituted solution:
24 hrs ……….(RT)
48 hrs ……….(2-8ºC)
Prepared infusion:
12 hrs ………. (RT)
First Generation Cephalosporins
Cephradine
500 mg, 1 gm
Cephradin
Farcosef
Velosef
NS
D5W
IM injection:
500 mg ….. 2 ml WFI
1 gm ….… 4 ml WFI
IV injection:
500 mg ….. 5 ml WFI
1 gm ….… 10 ml WFI
2 hrs ………...(RT)
24 hrs ………..(2-8ºC)
Second Generation Cephalosporins
Cefuroxime
750 mg, 1.5 g
Cefumax
NS
D5W
Gluc-NaCI
Harmann’s
Lactate
Ringer’s
IM injection:
Reconstitute 750 mg with 3 ml WFI
Conc. 250 mg/ml
IV injection:
750 mg …. 6ml WFI
- Conc. 125mg/ml
- 1.5gm …. 15ml WFI
- Conc. 100mg/ml
Over 3-5 min
Intermittent IV infusion:
Dilute reconstituted solution up to 50-
100ml of infusion fluid.
- Conc. 15 - 7.5mg/ml
Infuse over 30 minutes
24 hrs ………..(RT)
48 hrs ……… (2-8ºC)

5. Page5of14
Third Generation Cephalosporins
Cefoperazone
250 mg, 500 mg, 1
gm, 2 gm
Cefoperazone
Cefozone
Cefobid
Cefrone
Peracef
D5
W
NS
Lactate
Ringers’ (not
for
reconstitution)
2% lidocaine for
IM
administration
only
IM injection:
250 mg 0.7 ml WFI … 0.2 ml
lidocaine
500 mg 1.3 ml WFI … 0.4 ml
lidocaine
1 gm …2.6 ml WFI … 0.9 ml
lidocaine
2 gm …5.2 ml WFI … 1.8 ml
lidocaine
Conc. 250 mg/ml
IV injection:
Reconstitute 1 g with 10 ml
diluents/WFI
conc. 100 mg/ml
Over 3-5 min
Intermittent IV infusion:
Withdraw required dose and further dilute
with 20 – 100 ml diluents
Conc. 10 -50 mg/ml
15 – 60 min
* Note;
If water for injection is used as diluent,
--Not more than 20 ml is added to the vial.
- For Continuous infusion
- Each 1gm of injection is dissolved in 5
ml water for injection. Then added to
appropriate intravenous diluent.
Reconstituted & prepared
infusion:
24 hrs………… (RT)
5 days …………(2-8ºC)
Ceftazidime
250 mg, 500 mg, 1
gm
Cefzim
Cetazime
Fortazedim
Fortum
Sigmazidim
NS
D5
W
Gluc-NaCI
Hartmann’s
Lactate
Ringer’s
IM injection:
250 mg …… 1 ml WFI
500 mg …… 1.5 ml WFI
1 gm ……… 3 ml WFI
Conc. 333 mg/ml.
IV injection:
250 mg …… 2.5 ml WFI
500 mg …… 5 ml WFI
1 gm ……… 10 ml WFI
Conc. 100 mg/ml
Over 3-5 min
Intermittent IV infusion:
Withdraw required dose and further
(usually 50-100 ml NS)
with diluents.
Minimum 50 ml for 2 g
Minimum 100 ml for 3 g
≤ 100 mg/ml
over 20-30 min
12 hrs ………….(RT)
7 days …………..(2-8ºC)
Ceftizoxime
(Cefizox 1gm)
- Normal Saline
- Dextrose 5%
- Ringer’s
Lactate
IM injection:
Dissolve with 4ml of Lidocaine 1%.
Or Water for Injection.
- Conc. 250mg/ml
IV injection:
Dissolve with 10ml Water for
Injection.
Conc. 100mg/ml
Slowly over 3 – 5 minutes.
Intermittent Infusion:
- Dilute reconstituted solution up to 50 –
100ml of infusion fluid.
Conc. 20 – 10mg/ml
- Infuse over 20 – 60 minutes.
24 hrs ………….(RT)
96 hrs …………..(2-8ºC)

6. Page6of14
Cefotaxime
250 mg, 500 mg, 1
gm
Cefause, Cefaxim
Ceforan, Claforan
Cefotax, Foxime
Rametax
Sigmataxim
Taximodel
Xorin
NS
D5
W
Gluc-
NaCI
Hartmann
’s
2% lidocaine for
IM injection only
IM injection:
250 mg …… 2 ml WFI
500 mg …… 2 ml WFI
1 gm ……… 4 ml WFI
Conc. 250 mg/ml
IV injection:
250 mg …… 2 ml WFI
500 mg …… 2 ml WFI
1 gm ……… 4 ml WFI
Conc. 250 mg/ml
Over 3-5 min
Intermittent IV infusion:
Withdraw required dose and further
dilute with 40-100 ml diluents
Conc. 10-20 mg/ml
Over 20-60 min
24 hrs …….(2-8ºC)
Cefotax (Epico)
24 hrs …………(RT)
10 days …………(2-8ºC)
Ceforan (Pharco)
7 days …………(2-8ºC)
If diluent D5W or NS
5 days …………(2-8ºC)
Ceftriaxone
250 mg, 500 mg,
1 gm
Cefaxone, Cefotrix
Enoxirt, Epicephin
Kempoxone
Longacef
Mesporin
Nercefaxon
Ramecetrax
Triamerican
Trixamarc
Trixomash
Wintriaxone
Xoraxon
D5
W
NS
Gluc-NaCI
1% lidocaine for
IM injection only
Must not be
administered
simultaneously
with calcium
containing
solution (Ringer,
Hartman solution)
IM injection:
250 mg …… 1 ml WFI
500 mg …… 2 ml WFI
1 gm ……… 3.5 ml WFI
IV injection:
250 mg …… 5 ml WFI
500 mg …… 5 ml WFI
1 gm ……… 10 ml WFI
Conc. 100 mg/ml
Over 2-4 min
Intermittent IV infusion: Withdraw
required dose and further dilute up to 40
ml
Conc. 25 mg/ml
Over at least 30 min
Reconstitute & prepared
solution:
6 hrs …………. (RT)
24 hrs ………….(2-8ºC)
Fourth Generation Cephalosporin
Cefepime
500 mg, 1 gm
Cefepime
Forcetax
Maxipime
Pimfast
Spectracef
Wincef
D5W
NS
IM injection:
500 mg ……. 1.3 ml WFI
1 gm ………… 2.4 ml WFI
Conc. 280 mg/ml.
IV injection:
500 mg ….……. 5 ml WFI
1 gm …………. 10 ml WFI
2 gm …………. 10 ml WFI
Conc. 100 mg/ml.
Give over 3 – 5 min
Intermittent IV infusion:
Withdraw required dose and further
dilute in 50 or 100 ml diluents.
Usually 1 g in 50 ml diluents
Over 30 min
Reconstituted & prepared
infusion:
24 hrs …………..(RT)
7 days ………….(2-8ºC)
Cefepime (Pharco) …
24 hrs …………..(RT)
3 days ………….(2-8ºC)

7. Page7of14
Carbapenems
Imipenem 500
mg + Cilastatin
500 mg
Tienam
NS
D5W
Incompatible
with lactate
containing
solution.
Never administer as IV BOLUS
Intermittent IV infusion:
Reconstitute 500 mg imipenem with 10
ml NS
conc. 50 mg/ml
Withdraw required dose and further
dilute to ≤ 5mg/ml with diluents.
(usually 100-250 ml NS)
Conc. ≤ 5mg/ml
Dose ≤ 500 mg imipenem over 20-30
min
Dose ≥ 750 mg imipenem over 40-60
min
Prepared infusion:
4 hrs ………….(RT)
24 hrs ………..(2-8ºC)
Meropenem
500 mg
1 g
Meronem
Mirage
NS
D5W
IV injection:
Reconstitute to conc. of
50 mg/ml
500 mg with.. 10 ml WFI/NS
1 g with …….20 ml WFI/NS
Over 3-5 min
Intermittent IV infusion:
Withdraw required dose and further
dilute to1-20 mg/ml with diluents
Usually 50 – 200 ml NS
Conc. 1-20 mg/ml
over 15-30 min
Reconstituted solution in WFI:
3 hrs ………..(RT)
12 hrs ………(2-8ºC)
Prepared infusion: In NS:
3 hrs …………..(RT)
24 hrs …………(2-8ºC)
Prepared infusion In D5W :
Immediately
Doripenem
Monohydrate
500 mg
D5W
NS
Less stable in D5W
Intermittent IV infusion:
Reconstitute 500 mg with 10 ml WFI or
NS
Conc. 50 mg/ml
Withdraw required dose and further
dilute with diluents Usually 100 ml NS
Over 1 hr
May infuse over 4 hrs which allow the
serum concentration to maintain above
MIC
Reconstituted solution: 1 hr
Prepared infusion in NS:
8 hrs ………… (RT)
24 hrs ………...(2-8ºC)
Prepared infusion in D5W:
4 hrs …………… (RT)
24 hrs …………….(2-8ºC)

8. Page8of14
Monobactams
Aztreonam
500 mg, 1 gm
Azactam
- Normal Saline
- Dextrose 5%
- Ringer’s Solution
IM injection:
1.5 mL WFI or NaCl 0.9%
to …………. 500-mg vial
use 3 mL …. 1-g vial
Conc. 333.3mg/ml.
IV injection:
- Dissolve with 6– 10ml Water for
Injection.
- Conc. 166.6mg - 100 mg/ml
Give over 3 – 5 minutes.
Intermittent infusion
dilute reconstituted solution up to 50ml of
infusion fluid,
- Conc. 20mg/ml
infuse over 20 – 60 minutes.
24 hours….. RT
72 hours ……. 2-8ºC
Vancomycin
Vancomycin
500 mg
Edicin
Kempovancom
Vancobact
Vancolon
Vancomycin
D5W
NS
Hartmann’s
NOT for IM
administration
Intermittent IV infusion:
Solution must be diluted prior to
administration
500 mg …… 10 mL WFI
1000 mg …… 20 mL WFI
Conc. 50 mg/ml
Intermittent IV infusion: Withdraw
required dose and further dilute 500 mg
dilutes with at least 100 ml diluents
Over at least 1 hr
Over 2 hrs for 1g dose.
Max rate 10 mg/min
If red man syndrome appear:
Infuse over 1.5 hrs - 2 hrs and increase
the dilution volume
Continuous IV infusion:
Withdraw required dose and add with
sufficiently large volume of diluents.
Over 24 hrs (only if intermittent technique is
not feasible)
Rotate infusion site frequently to
avoid extravasation
96 hrs………… (2-8ºC)

9. Page9of14
semisynthetic glycopeptide
Teicoplanin
200 mg
Targocid
NS
D5W
Gluc-NaCI
Hartmann’s
IM injection
Reconstitute 200 mg in 3 ml
IV injection:
Reconstitute 200 mg in 3 ml
Over 3-5 minutes
Intermittent IV infusion: Withdraw
required dose and further dilute with
diluents. Usually 100 ml NS/ D5W
Over 30 minutes
24 hrs ………. (2-8ºC)
polypeptide antibiotics
Polymycin B
500,000 IU
NS
Procaine solution
D5W for IV
infusion only
IM injection:
Reconstitute 500,000 IU with 2 ml
WFI/diluents
IV infusion:
Reconstitute and further dilute 500,000
with 300-500 ml D5W
Reconstituted solution:
3 days……….. (2-8ºC)
Macrolides
Erythromycin
Lactobionate
500 mg
NS
Do not use D5W as
a diluents unless
0.5 mL 8.4%
NaHCO3 added
per each 100 ml
D5W
Never administer as direct IV
injection (Fatal ventricular
arrhythmias)
Intermittent IV infusion:
Reconstitute 500 with 10 ml WFI
Conc. 50 mg/ml.
Withdraw required dose and further
dilute to 1 - 2 mg/ml with diluents.
At least 100 ml NS of infusion
solution.
If phlebitis/pain occur with used
dilution, consider further dilution
Conc. 1-2 mg /ml Max: 5 mg/ ml
Give more slowly in patients with risk
factors or history of arrhythmias.
Over 20-60 min
Reconstituted solution:
8 hrs………… (RT)
14 days……… (2-8ºC)
Prepared infusion: 24 hrs
Protect from light
Azithromycin
500 mg
Zithromax
Azithroglob
NS
D5W
Lactated Ringer’s
NOT for IM or IV bolus
administration
Intermittent IV infusion: Over 3 hrs
(1 mg/ml)
Over 1 hr (2 mg/ml)
Minimum duration of 1 hr
Reconstitute 500 mg with 4.8 ml WFI:
Conc. 100 mg/ml
Reconstituted solution 100 mg/ml
further dilute with diluents to:
500 ml, 1 mg/ml
250 ml, 2 mg/ml
Reconstituted solution:
24 hrs ………… (< 30ºC)
Prepared infusion 1-2 mg/ml:
24 hrs ……………… (RT)
7 days ……………… (2-8ºC)

10. Page11of14
ž Aminoglycosides
Amikacin
100 mg/ 2mL
500 mg/2mL
Amikabiotic
Amikacin
Amikaskiv
Ramikabiotic
D5W
NS
Lactate Ringer’s
IM (preferred route)
IV injection:
Over 2-3 min
IM & IV injection:
Withdraw required dose without
further dilution.
Intermittent IV infusion: Withdraw
required dose & further dilute to 0.25 –
5mg/ ml with diluents.
(usually 100 ml NS)
Adult: over 30 – 60 min
Infant: 1-2 hrs
Prepared infusion
0.25 – 5 mg/ml:
24 hrs ……….. (RT)
2 days ……….. (2-8ºC)
Unused portion in vial
should be discarded
Protect from light and do not
freeze
Gentamicin
20, 80 mg /2
ml
Epicogent
Garamycin
Gentamycin
NS
D5W
Gluc-NaCl
IM injection:
Volume > 4 ml, distributed btw ≥ 2
injection site
IV injection:
(↑ risk of neuromuscular
blockage) - Conc. 40mg/ml
Over 2-3 min
Intermittent IV infusion: Withdraw
required dose and further dilute with
diluents.
Conc. 1 mg/ml
- Dilute up to 50 – 200ml of infusion fluid.
- Infuse over 30-120 min
Prepared IV infusion: 24 hrs
Streptomycin
Sulphate 1g
Streptomycin
NA IM injection
Reconstitute 1 g with WFI
4.2 ml, 200 mg/ml
3.2 ml, 250 mg/ml
1.8 ml, 400 mg/ml
NOT recommended for IV
administration
Injection should be freshly
prepared and discard unused
portion
Protect from light
Clindamycin
Clindamycin
Phosphate
300 mg, 600 mg
Dalacin
Alfaclindamycin
D5W
NS
Gluc-NaCI
IM injection:
Administration of more than 600mg at
once is not recommended.
- Conc. 150mg/ml
Never administer as BOLUS
Intermittent IV infusion: Withdraw
required dose and further dilute to ≤ 18
mg/ml with diluents.
Over at least 10-60 minutes
300 mg ...50ml…….10 min
600 mg …50ml……20 min
900 mg ….100ml….30 min
1200 mg ..100ml…..40 min
24 days ………. (RT)

11. Page11of14
Linezolid
Linezolid
600 mg/300 ml
Linezolid
Linezomentin
Zyvoxenam
Zyvox
NS
D5W
Gluc-NaCI
Hartmann’s
Lactate
Ringer’s
Intermittent IV infusion: Over 30-
120 min
Flush line with D5%W, NS or
Lactate Ringers’ before and after
infusing linezolid
Withdraw required dose without
further dilution.
Once opened, use immediately
Discard any unused
solution.
glycylcycline antibiotic that is structurally similar to tetracycline antibiotics
Tigecycline
50 mg
Standiga
Tygacil
D5W
NS
Intermittent IV infusion:
Reconstitute 50 mg with 5.3 ml diluents
Conc. 10 mg/ml
Withdraw required dose and further
dilute to ≤1 mg/ml.
Usually 100 ml diluents
Conc. ≤ 1 mg/ml
Over 30-60 minutes
48 hrs ……….(2-8ºC)
Fusidic Acid
Fusidic Acid
500 mg
D5W
NS
Hartmann’s
NOT for IM or subQ
administration
Intermittent IV infusion:
Reconstitute 500 mg with 10 ml of
supplied diluents:
Conc. 50 mg/ml.
Withdraw required dose and further
dilute to 1 - 2 mg/ml with diluents
(usually 500 ml NS)
Conc. 1-2 mg/ml
For patient < 50 kg, required dose
should be diluted to at least 10 FOLD
in compatible diluents.
Over ≥ 2 hrs
Prepared infusion: 24 hrs

12. Page12of14
Fluoroquinolones
Ciprofloxacin
200 mg/100 ml
Cipro-sol
Ciprocin
Ciprofloxacin
Rancif
NA Intermittent IV infusion:
200 mg infuse over 30 min
400 mg infuse over 60 min
Use opened vials
immediately.
Discard any unused
solution.
Levofloxacin
500 mg
Alfacef
Levoflox
Levoxin
Tavanic
NS
D5W
2.5% Dextrose in
Normal saline
Intermittent IV infusion:
Infusion time must be
at least 60 minutes.
3 hours after perforation
of the rubber stopper
Moxifloxacin
400 mg/250 ml
Moxiflox
Moxifloxacin
Never administer as BOLUS Intermittent IV infusion: Over 60
minutes
Once opened, use
immediately
Discard any unused
solution
ž Sulfonamides
Sulfamethoxazole
400 mg+
Trimethoprim
80 mg
D5W
NS
Gluc-NaCI
Limited stability in
NS
NOT for IM administration Intermittent IV infusion: over 60-90
hrs
IV infusion duration NOT
> 1.5 hrs
Solution must be diluted prior to
administration
Withdraw required dose and further
dilute with diluents. Dilute 1 mL
Bactrim to 25-30 mL diluents.
Usually 15 ml dilute to 500 ml diluents
Fluid restriction:
Add each 5 ml to 75 ml D5W & infuse ≤
60 min
Prepared infusion: 24 hrs, except:
6 hrs: 5 ml/125 ml
4 hrs: 5 ml/100 ml
2 hrs: 5 ml/75 ml Do not
refrigerate Protect from
light
Crystallization or turbidity may
develop at any time. Discard if
occur.

13. Page13of14
Anti-Anaerobic
Metronidazole
500 mg/100 mL
NS
D5W
Gluc-NaCI
Incompatible with
D10%W &
Hartmann’s
Intermittent IV infusion:
over 30-60 min
Once opened, use
immediately
Discard any unused solution
Do not refrigerate
Anti-fungal
Amphotericin B
50 mg
Ambisome
Photericin
D5W
Incompatible with
NS and all
electrolyte
solutions
Intermittent IV infusion: Over 20-30
min (test dose)
Over 4 to 6 hrs or longer if not tolerated.
Flush line again with D5W after
infusion complete
Reconstitute 50 mg with 10 ml WFI:
Conc. 5 mg/ml
Withdraw required dose and further
dilute to:
Peripheral infusion
500 ml, ≤ 0.1 mg/ml
Central infusion:
250 ml, ≤ 0.25 mg/ml
Reconstituted solution
5 mg/ml:
24 hrs ……. (RT)
7 days ……(2-8ºC)
Prepared infusion:
24 hrs ……..(RT)
2 days ……. (2-8ºC) Protect
from light
Fluconazole
100 mg/50ML
Diflucan
Flucand
Fluctobar
Naviluca
Sunnyfungal
NS
D5W
Hartmann’s
Ringer’s
Intermittent IV infusion:
Over 1-2 hrs
Max rate:
200 mg/hr (100 ml/hr)
Infusions are single use only.
Discard any unused portion
Caspofungin
Acetate
50 mg/70 mg
Cancid
NaCl
solution
Hartmann’s
Incompatible with
Glucose solution
Intermittent IV infusion:
Reconstitute 50 mg / 70 mg
with 10.5 ml WFI:
conc. 50 / 70 mg/ml
Withdraw required dose and further
dilute to ≤ 0.5 mg/ml with diluents.
Usually 250 ml NS
Over 1 hr
Reconstituted solution:
1 hrs ………… (RT)
Prepared infusion:
24 hrs ………...(RT)
2 days ………..(2-8ºC)

14. Page14of14
Anti-viral
Acyclovir
250 mg
Zovirax
Aciclovir
Supraviran
D5W
NS
Lactate Ringer’s
NOT for IM or subQ
administration
Intermittent IV infusion:
Over a minimum of 1 hr
Reconstitute 250 mg with 10 ml WFI
Conc. 25 mg/ml
Withdraw required dose and further
dilute concentration ≤ 5 mg/ml with
diluents (usually NS)
≤ 5 mg/ml
dose ≤ 500 mg to 100 ml dose > 500
mg to 250 ml
Reconstituted solution 25
mg/ml:
12 hrs ……… (RT)
Prepared infusion ≤ 5 mg/ml
:
24 hrs ……… (RT)
Do not refrigerate, may
precipitate
Abbreviations
D5W 5% Dextrose in Water
Gluc-
NaCI
Glucose / Sodium
Chloride Solution
IM Intramuscular
IV Intravenous
LT Lactated Ringers
NS Normal Saline 0.9%
References:
 Handbook on Injectable Drugs
 Injectable Drugs Guide
 Drug inserts
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