1. *****************************************************************
*Project ***********
*****************************************************************
********
*PROGRAM NAME: TABLE8
*PROGRAM LOCATION: ***********
*PROGRAM PURPOSE: create Table8-Other hospitalization analyses at 90
days
*SAS VERSION: 9.4
*AUTHOR: Cynthia Guan
*DATE: 05-11-2015
*****************************************************************
********;
*call the library;
options nodate mprint symbolgen mtrace mlogic nonumber nofmterr;
%macro libclear;
%if %sysfunc(libref(library))=0 %then /*libref function returns
0 when an existing libref*/
%sysfunc(libname(library)); /*libname function clears a
libref when no other arguments included*/
%mend;
%libclear;
filename library '******************';
options sasautos=(library);
%include library;
%library;
data work.hospanls;
set anlysds.hospanls;
run;
proc sort data=hospanls;
by subject;
run;
%macro unhosp(var,order);
proc genmod data=hospanls;
model &var=trtgrp /offset=log dist=poi link=log;
ods output parameterestimates=poss_&var;
run;

2. data temp_&var;
length order $50;
set poss_&var;
where parameter="Trtgrp";
order="&order";
keep probchisq order;
run;
%mend;
%unhosp(var=cv_hdays,order=0);
%unhosp(var=any_hdays,order=2);
%unhosp(var=HF_year,order=4);
%unhosp(var=ucv_hdays,order=6);
%unhosp(var=all_year,order=8);
%macro adhosp(var,order);
proc genmod data=hospanls;
class trtgrp(param=ref ref=last) nyha(param=ref ref=first)
gender(param=ref ref=first);
model &var=trtgrp nyha gender age __ef_/offset=log dist=poi
link=log;
estimate 'trtgrp adj rate' int 1 trtgrp 1 0/exp;
estimate 'control adj rate' int 1 trtgrp 0 1/exp;
ods output parameterestimates=_poss&var
estimates=estima&var;
run;
data _temp&var;
length order $50;
set _poss&var;
where Parameter='Trtgrp';
order="&order";
keep probchisq order;
run;
%mend;
%adhosp(var=cv_hdays,order=1);
%adhosp(var=any_hdays,order=3);
%adhosp(var=HF_year,order=5);
%adhosp(var=ucv_hdays,order=7);
%adhosp(var=all_year,order=9);

3. data temp_pval;
merge temp_cv_hdays temp_any_hdays temp_HF_year temp_ucv_hdays
temp_all_year;
by order;
type=0;
run;
data _temp_pval;
merge _tempcv_hdays _tempany_hdays _tempHF_year _tempucv_hdays
_tempall_year;
by order;
type=0;
run;
data temp;
set temp_pval _temp_pval;
by order;
run;
%macro num(dts,vari,group,order);
proc means data=&dts;
class &group;
var &vari;
output out=n&vari n=n&vari;
run;
data n&vari;
set n&vari;
if &group='' then &group=3;
run;
*convert to character;
data cn&vari;
length c&vari $35 order $50;
format n&vari 6.;
set n&vari;
type=0;
if n&vari=. then c&vari=0;
else c&vari=compress(put(n&vari,comma5.));
order="&order";
drop _TYPE_ _FREQ_ n&vari;
run;
proc sort data=cn&vari;

4. by &group;
run;
*get the mean of subject by each group;
proc means data=&dts noprint;
class &group;
var &vari;
output out=mean&vari mean=m&vari std=sd&vari;
run;
*add a number to the total group;
data mean&vari;
set mean&vari;
if &group="" then &group=3;
run;
*convert to character;
data cmean&vari;
length c&vari $35 order $50;
set mean&vari;
type=1;
if sd&vari ne . and m&vari ne . then
c&vari=compress(put(m&vari,6.2)||'('||put(sd&vari,6.2)||')');
else if m&vari=. and sd&vari=. then c&vari='0(0)';
else if sd&vari=. then c&vari=compbl(put(m&vari,6.2)||'(0)');
else if m&vari=. then c&vari=compbl('(0)'||put(sd&vari,6.2));
order="&order";
drop _type_ _freq_ m&vari sd&vari;
run;
proc sort data=cmean&vari;
by &group;
run;
*get the median, min and max of subjects by each group;
proc means data=&dts noprint;
class &group;
var &vari;
output out=mmm&vari min=min&vari max=max&vari median=med&vari;
run;
*add a number to the trtgrp of the total group;
data mmm&vari;
set mmm&vari;

5. if &group="" then &group=3;
run;
*convert to character;
data cmmm&vari;
length c&vari $35 order $50;
format min&vari max&vari 5.;
set mmm&vari;
type=2;
if min&vari= . then c&vari='0(0,0)';
else
c&vari=compress(put(med&vari,6.2)||'('||put(min&vari,6.2)||','||p
ut(max&vari,6.2)||')');
order="&order";
drop min&vari max&vari med&vari _TYPE_ _FREQ_ ;
run;
proc sort data=cmmm&vari;
by &group;
run;
data merge&vari;
merge cmean&vari cn&vari cmmm&vari;
by type;
format trtgrp trtgrpf.;
run;
proc transpose data=merge&vari out=tr&vari(drop=_name_);
by type order;
id &group;
var c&vari;
run;
%mend;
%num(dts=hospanls,vari=cv_hdays,group=trtgrp,order=0);
%num(dts=hospanls,vari=any_hdays,group=trtgrp,order=2);
%num(dts=hospanls,vari=HF_year,group=trtgrp,order=4);
%num(dts=hospanls,vari=ucv_hdays,group=trtgrp,order=6);
%num(dts=hospanls,vari=all_year,group=trtgrp,order=8);
data ntemp_;
merge trcv_hdays trany_hdays trHF_year trucv_hdays trall_year;
by order;
run;

6. %macro _num(dts,vari,group,order);
proc means data=&dts;
class &group;
var &vari;
output out=_n&vari n=n&vari;
run;
data _n&vari;
set _n&vari;
if &group='' then &group=3;
run;
*convert to character;
data _cn&vari;
length c&vari $35 order $50;
format n&vari 6.;
set _n&vari;
type=0;
if n&vari=. then c&vari=0;
else c&vari=compress(put(n&vari,comma5.));
order="&order";
drop _TYPE_ _FREQ_ n&vari;
run;
proc sort data=_cn&vari;
by &group;
run;
*get the mean of subject by each group;
proc means data=&dts noprint;
class &group;
var &vari;
output out=_mean&vari mean=m&vari std=sd&vari;
run;
*add a number to the total group;
data _mean&vari;
set _mean&vari;
if &group="" then &group=3;
run;
*convert to character;
data _cmean&vari;
length c&vari $35 order $50;

7. set _mean&vari;
type=1;
if sd&vari ne . and m&vari ne . then
c&vari=compress(put(m&vari,6.2)||'('||put(sd&vari,6.2)||')');
else if m&vari=. and sd&vari=. then c&vari='0(0)';
else if sd&vari=. then c&vari=compbl(put(m&vari,6.2)||'(0)');
else if m&vari=. then c&vari=compbl('(0)'||put(sd&vari,6.2));
order="&order";
drop _type_ _freq_ m&vari sd&vari;
run;
proc sort data=_cmean&vari;
by &group;
run;
*get the median, min and max of subjects by each group;
proc means data=&dts noprint;
class &group;
var &vari;
output out=_mmm&vari min=min&vari max=max&vari
median=med&vari;
run;
*add a number to the trtgrp of the total group;
data _mmm&vari;
set _mmm&vari;
if &group="" then &group=3;
run;
*convert to character;
data _cmmm&vari;
length c&vari $35 order $50;
format min&vari max&vari 5.;
set _mmm&vari;
type=2;
if min&vari= . then c&vari='0(0,0)';
else
c&vari=compress(put(med&vari,6.2)||'('||put(min&vari,6.2)||','||p
ut(max&vari,6.2)||')');
order="&order";
drop min&vari max&vari med&vari _TYPE_ _FREQ_ ;
run;
proc sort data=_cmmm&vari;

8. by &group;
run;
data _merge&vari;
merge _cmean&vari _cn&vari _cmmm&vari;
by type;
format trtgrp trtgrpf.;
run;
proc transpose data=_merge&vari out=_tr&vari(drop=_name_);
by type order;
id &group;
var c&vari;
run;
%mend;
%_num(dts=hospanls,vari=cv_hdays,group=trtgrp,order=1);
%_num(dts=hospanls,vari=any_hdays,group=trtgrp,order=3);
%_num(dts=hospanls,vari=HF_year,group=trtgrp,order=5);
%_num(dts=hospanls,vari=ucv_hdays,group=trtgrp,order=7);
%_num(dts=hospanls,vari=all_year,group=trtgrp,order=9);
data _ntemp_;
merge _trcv_hdays _trany_hdays _trHF_year _trucv_hdays
_trall_year;
by order;
run;
data temp;
merge ntemp_ _ntemp_ temp_pval _temp_pval;
by order;
run;
data otherhos;
length order $50;
set temp;
format order hosdaysf. type typef.;
run;
options orientation=landscape ls=132 ps=49 missing=' ';
ods rtf file="*********************" style=minimal;

9. ods escapechar="^";
Title1 j=l f=arial h=8pt '***************';
Title2 j=l f=arial h=8pt '*************' j=r "page ^{pageof}";
title3 j=c f=arial h=10pt 'Table 8.';
title4 j=c f=arial h=10pt "ITT Analysis Set";
title5 j=c f=arial h=10pt "Other Hospitalization Analyses at 90 days";
footnote1 j=l f=arial h=8pt "Note:All subjects are randomized.";
footnote2 j=l f=arial h=8pt "*P-values are based on Poisson
regression";
footnote3 j=l f=arial h=8pt "#-Unadjusted *-Adjusted for
age,gender,LVEF and NYHA class at baseline";
footnote4 j=r h=6pt "Executed:&sysdate9 &systime";
proc report data=otherhos nowindows headskip missing split='|'
spacing=2
style(header)=[font_face=arial font_size=8pt
font_weight=bold BORDERBOTTOMSTYLE=solid borderbottomcolor=black
backgroundcolor=white]
style(column)=[font_face=arial font_size=8pt
BORDERBOTTOMSTYLE=solid]
style(summary)=[font_face=arial font_size=8pt]
style(report)=[font_face=arial font_size=8pt rules=groups
frame=hsides asis=on cellspacing=2 cellpadding=2];
column order type treatment control total probchisq;
define order/group order=data left ' ' flow " "
style(column)=[cellwidth=25%];
define type/left ' ' flow "Type" style(column)=[cellwidth=15%];
define Treatment/ center flow "Treatment Group"
style(column)=[cellwidth=15%];
define control/center flow "Placebo Group"
style(column)=[cellwidth=15%];
define total/center flow "Total Group"
style(column)=[cellwidth=15%];
define probchisq/group order=data center flow "p-value"
style(column)=[cellwidth=10%];
quit;

10. ods rtf close;
proc datasets library=work kill;
quit;
Table 8
ITT Sample
Other hospitalization analyses at 90 days
Total
(N) Treatment
(N)
Control
(N)
P-value
Number of days hospitalized for CV causes# xx xx xx x.xxx
Number of days hospitalized for CV cause* xx xx xx x.xxx
Number of days hospitalized for any cause# xx xx xx x.xxx
Number of days hospitalized for any cause* xx xx xx x.xxx
HFH per life year# xx xx xx x.xxx
HFH per life year* xx xx xx x.xxx
Unplanned CV hospitalizations per life year# xx xx xx x.xxx
Unplanned CV hospitalizations per life year* xx xx xx x.xxx
All cause hospitalizations per life year # xx xx xx x.xxx
All cause hospitalizations per life year * xx xx xx x.xxx
# unadjusted * adjusted for age, gender, hospitalization within the prior 30d, LVEF at baseline, NYHA Class at baseline