Heavy metals toxicology for 3rd year pharmacy students , prepared by Nelsonmayor Makur Wel

1. HEAVY METALS MCQS PreparedBy 111 Mayor Makur
Note any letter mark with red coloris answer to multiplechoicein each question.
1. No observedadverseeffectlevel (NOAEL)
a. The conditionof experimentalanimalswhennoadverse effectcanbe observed.
b. The maximumdose atwhichthe toxicantshownosignsof toxicity.
c. A conditionwhere adverse effectsexist,butare hard to observe.
d. A and C
e. The maximumdose of achemical whichcausedthe death,hence nootheradverse effectgotobserved.
2. Whichof the followingcanbe a source of toxicants?
a. Car B
b. Fruits C
c. Cosmetics D
d. Medicines
e. All of the above
3. Whichone of the followingelementsisrequiredbyour bodyfor normal functioningof some enzymes?
a. Mercury (Hg) B
b. Zinc(Zn)
c. Lead (Pb)
d. Antimony(Sb)
e. Scandium(Sc
4. Whichone of the elementsisnotrequiredbyourbody?
a. Selenium(Se)
b. Potassium(K)
c. Copper(Cu)
d. Arsenic(As)
e. Phosphorus(P)
5. Where inthe body dotoxicants/chemicalsgetstored?
a. Plasmaproteins
b. Body fat
c. Liverand kidneys
d. Bones

2. e. All of the above
6. The mode of excretionof xenobioticfromthe body.Selectwhichapplies.
a. Urinary
b. Fecal (non-absorbed,biliaryexcretion
c. Exhalation
d. Sweat,salivaand milk
e. All of the above
7. Whichone of the followingare the maintargetsof leadtoxicity?
a. Liverand kidneys
b. Nervoussystemandhematopoieticsystem
c. Heart and lung
d. Bonesand muscle
e. Skinand hair
8. Organic mercurytargets_________ whereasinorganicmercuryprimarilytargets__________.
a. Bones,ligaments
b. Liver,hematopoieticsystem
c. Nervoussystem,kidneys
d. Hematopoieticsystem,nervoussystem
e. Liver,nervoussystem
9. ‘Itai-itai’disease iscausedby_____
a. Cadmium
b. Mercury
c. Lead
d. Copper
e. Chromium
10. ‘Blackfoot’disease is causedby_______
a. Cadmium
b. Mercury
c. Lead
d. Copper
e. Chromium

3. 11. What isthe antidote formethanol poisoning?
a. Atropine
b. Britishanti lewisite
c. Charcoal
d. Ethanol
e. DisodiumEDTA
12. What isthe mode of actionof carbon monoxide (CO)?
a. It reducesthe oxygenabsorptionbydirectlyorindirectlydamagingthe alveoli.
b. It destroysthe red bloodcells.
c. Combineswithhemoglobintoreduce oxygen carryingcapacityof RBCs.
d. It has a corrosive effectonairways,speciallybronchi andbronchioles.
e. It altersthe structure of the hemoglobin
13. Whichof the followingisnota possible route of exposure toatoxicantinthe environment?
a. Inhalation
b. Ingestion
c. Dermal absorption
d. Transdermal
e. None of the above
14. Who ismost likelytoexhibittoxiceffectsof environmental tobaccosmoke (ETS).
a. A personwithasthma
b. An obese teenager
c. An athlete
d. A childin2nd grade
e. A driverwhosmokes
15. Emphysemaisan inflammatorytissue damage,which canbe causedby toxicants.Whichorganisaffectedincase of emphysema?
a. Kidneys
b. Heart
c. Lung
d. Skin

4. e. Nervoussystem
16. Followingare the normal functionsof the metalsinthe bodyexcept_________.
a. Calciuminbone formation
b. PhosphorusinATP
c. Iron inhemoglobin
d. Lithiuminsodiumchannelsactivities
e. Magnesiuminenzyme functions
17. Why activatedcharcoal isadministeredincase of oral poisoning?
a. It deactivatestoxicants
b. It increasesthe metabolicprocessesof detoxification
c. It chemicallydetoxifiesthe toxicants
d. It chelatesmetal circulatinginthe blood
e. It reducesabsorptionof toxicantsbyadsorbingthem
18. Which of the followingisassociatedwithacetaminophentoxicity?
a. Methanol
b. N-acetyl-p-benzoquinone imine
c. 3-(1-methylpyrrolidin-2-yl)pyridine
d. Benzo(a)pyrene
e. Diethyl nitrosamine
19. Who is the mostsusceptible tohepatotoxicitybyhigh dosesof acetaminophen(paracetamol)?
a. A childinsecondgrade
b. An oldlady
c. A personon fasting
d. An alcoholic
e. A factoryworker

5. 20. Whichone of the arseniccompoundscauseshemolysis?
a. Arsenictrioxide(As2O3)
b. Arsenicpentoxide (As2O5)
c. Arsenicpentafluoride(AsF5)
d. Arsenictrisulfide (As2S3)
e. Arsine (AsH3)
21. Cadmiumisa highlytoxicmetal thatcauses__________
a. Chemical pneumonitis
b. Damage to renal tubules
c. Cancer
d. GI tract irritation
e. All of the above
22. Commontoxicitytargetof elementalmercuryandmethyl mercuryis________.
a. Kidneys
b. Liver
c. Muscles
d. Skin
e. CNS
23. Commontoxicitytargetof inorganicmercuricsaltsandorganicmercury is________.
a. Kidneys
b. Liver
c. Muscles
d. Skin
e. CNS
24. Commontoxicitytargetof elementalmercury,inorganicmercuricsaltsandorganicmercuryis b________.
a. Kidneys
b. Liver
c. Muscles
d. Skin
e. CNS

6. 25. Major rout of exposure toelemental mercuryis_______.
a. Dermal
b. Inhalation
c. Ingestion
d. Intravenous
e. Intramuscular
26. ‘Metal fume fever’iscausedbyinhalationof fumesof _______. b
a. Zincoxide
b. Elemental mercury
c. Chromiumoxide
d. Ferricchloride
e. Anyof the metal oxide
27. Antidote forthe arsenicpoisoning
a. N-acetyl cysteine
b. Sodiumnitrate
c. Dimercaprol
d. EDTA
e. Fuller’searth
28. Antidote foracetaminophen/paracetamol
a. N-acetyl cysteine
b. Sodiumnitrate
c. Dimercaprol
d. EDTA
e. Fuller’searth